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Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era

(2024) NEURO-ONCOLOGY. 26(1). p.191-202
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Abstract
Background Survival data of diffuse adult-type glioma is mostly based on prospective clinical trials or small retrospective cohort studies. Real-world data with large patient cohorts is currently lacking.Methods Using the nationwide, population-based Belgian Cancer Registry, all known histological reports of patients diagnosed with an adult-type diffuse glioma in Belgium between 2017 and 2019 were reviewed. The ICD-O-3 morphology codes were matched with the histological diagnosis. The gathered data were transformed into the 2021 World Health Organization classification of CNS tumors using the IDH- and 1p/19q-mutation status.Results Between 2017 and 2019, 2233 diffuse adult-type gliomas were diagnosed in Belgium. Full molecular status was available in 67.1% of identified cases. The age-standardized incidence rate of diffuse adult-type glioma in Belgium was estimated at 8.55 per 100 000 person-years and 6.72 per 100 000 person-years for grade 4 lesions. Median overall survival time in IDH-wild-type glioblastoma was 9.3 months, significantly shorter compared to grade 4 IDH-mutant astrocytoma (median survival time: 25.9 months). The 3-year survival probability was 86.0% and 75.7% for grades 2 and 3 IDH-mutated astrocytoma. IDH-wild-type astrocytoma has a worse prognosis with a 3-year survival probability of 31.6% for grade 2 and 5.7% for grade 3 lesions.Conclusions This registry-based study presents a large cohort of adult-type diffuse glioma with known molecular status and uses real-world survival data. It adds to the current literature which is mainly based on historical landmark trials and smaller retrospective cohort studies.
Keywords
diffuse adult-type glioma, epidemiology, survival, RANDOMIZED PHASE-III, CENTRAL-NERVOUS-SYSTEM, ADJUVANT TEMOZOLOMIDE, GENOMIC ANALYSIS, GRADE, GLIOBLASTOMA, IDH, TUMORS, CLASSIFICATION, RADIOTHERAPY

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MLA
Pinson, Harry, et al. “Epidemiology and Survival of Adult-Type Diffuse Glioma in Belgium during the Molecular Era.” NEURO-ONCOLOGY, vol. 26, no. 1, Oxford Univ Press Inc, 2024, pp. 191–202, doi:10.1093/neuonc/noad158.
APA
Pinson, H., Silversmit, G., Vanhauwaert, D., Vanschoenbeek, K., Kalala Okito, J.-P., De Vleeschouwer, S., … De Gendt, C. (2024). Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era. NEURO-ONCOLOGY, 26(1), 191–202. https://doi.org/10.1093/neuonc/noad158
Chicago author-date
Pinson, Harry, Geert Silversmit, Dimitri Vanhauwaert, Katrijn Vanschoenbeek, Jean-Pierre Kalala Okito, Steven De Vleeschouwer, Tom Boterberg, and Cindy De Gendt. 2024. “Epidemiology and Survival of Adult-Type Diffuse Glioma in Belgium during the Molecular Era.” NEURO-ONCOLOGY 26 (1): 191–202. https://doi.org/10.1093/neuonc/noad158.
Chicago author-date (all authors)
Pinson, Harry, Geert Silversmit, Dimitri Vanhauwaert, Katrijn Vanschoenbeek, Jean-Pierre Kalala Okito, Steven De Vleeschouwer, Tom Boterberg, and Cindy De Gendt. 2024. “Epidemiology and Survival of Adult-Type Diffuse Glioma in Belgium during the Molecular Era.” NEURO-ONCOLOGY 26 (1): 191–202. doi:10.1093/neuonc/noad158.
Vancouver
1.
Pinson H, Silversmit G, Vanhauwaert D, Vanschoenbeek K, Kalala Okito J-P, De Vleeschouwer S, et al. Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era. NEURO-ONCOLOGY. 2024;26(1):191–202.
IEEE
[1]
H. Pinson et al., “Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era,” NEURO-ONCOLOGY, vol. 26, no. 1, pp. 191–202, 2024.
@article{01HKWV4CFWT0SARGD2Q4RRTEMX,
  abstract     = {{Background Survival data of diffuse adult-type glioma is mostly based on prospective clinical trials or small retrospective cohort studies. Real-world data with large patient cohorts is currently lacking.Methods Using the nationwide, population-based Belgian Cancer Registry, all known histological reports of patients diagnosed with an adult-type diffuse glioma in Belgium between 2017 and 2019 were reviewed. The ICD-O-3 morphology codes were matched with the histological diagnosis. The gathered data were transformed into the 2021 World Health Organization classification of CNS tumors using the IDH- and 1p/19q-mutation status.Results Between 2017 and 2019, 2233 diffuse adult-type gliomas were diagnosed in Belgium. Full molecular status was available in 67.1% of identified cases. The age-standardized incidence rate of diffuse adult-type glioma in Belgium was estimated at 8.55 per 100 000 person-years and 6.72 per 100 000 person-years for grade 4 lesions. Median overall survival time in IDH-wild-type glioblastoma was 9.3 months, significantly shorter compared to grade 4 IDH-mutant astrocytoma (median survival time: 25.9 months). The 3-year survival probability was 86.0% and 75.7% for grades 2 and 3 IDH-mutated astrocytoma. IDH-wild-type astrocytoma has a worse prognosis with a 3-year survival probability of 31.6% for grade 2 and 5.7% for grade 3 lesions.Conclusions This registry-based study presents a large cohort of adult-type diffuse glioma with known molecular status and uses real-world survival data. It adds to the current literature which is mainly based on historical landmark trials and smaller retrospective cohort studies.}},
  author       = {{Pinson, Harry and  Silversmit, Geert and Vanhauwaert, Dimitri and  Vanschoenbeek, Katrijn and Kalala Okito, Jean-Pierre and  De Vleeschouwer, Steven and Boterberg, Tom and  De Gendt, Cindy}},
  issn         = {{1522-8517}},
  journal      = {{NEURO-ONCOLOGY}},
  keywords     = {{diffuse adult-type glioma,epidemiology,survival,RANDOMIZED PHASE-III,CENTRAL-NERVOUS-SYSTEM,ADJUVANT TEMOZOLOMIDE,GENOMIC ANALYSIS,GRADE,GLIOBLASTOMA,IDH,TUMORS,CLASSIFICATION,RADIOTHERAPY}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{191--202}},
  publisher    = {{Oxford Univ Press Inc}},
  title        = {{Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era}},
  url          = {{http://doi.org/10.1093/neuonc/noad158}},
  volume       = {{26}},
  year         = {{2024}},
}

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