Advanced search
2 files | 1.40 MB Add to list

Men who have sex with men and risk for transfusion-transmissible infections in blood donors in Western countries : a systematic review update

(2023) VOX SANGUINIS. 118(9). p.709-720
Author
Organization
Abstract
Background and Objectives: This systematic review update summarizes evidence concerning transfusion-transmissible infections (TTIs) in male blood donors reporting sex with another man (MSM) or after easing the MSM deferral period. Materials and Methods: We searched five databases, including studies comparing MSM versus non-MSM donors (Type I), MSM deferral periods (Type II) or infected versus non-infected donors (Type III) in Western countries, and used GRADE to determine evidence certainty. Results: Twenty-five observational studies were included. Four Type I studies suggest that there may be an increased risk for overall TTIs, human immunodeficiency virus (HIV), hepatitis B virus (HBV) and syphilis in MSM donors, but the evidence is very uncertain. There was insufficient evidence of MSM with low-risk sexual behaviour. A Type II study indicates that easing the MSM deferral period to 1 year may have little to no effect on TTI risk. TTI prevalence in blood donors under 5-year, 1-year, 3-month or risk-based deferral in eight other Type II studies was too low to provide clear conclusions on the effect of easing the deferral. Three Type III studies reported that MSM may be a risk factor for HIV. Increased risk of HBV, hepatitis C virus and HTLV-I/II could not be shown. The evidence from Type III studies is very uncertain. Conclusion: There may be an increased risk of HIV in MSM blood donors. Shortening the deferral from permanent to 1 year may have little to no effect on TTI risk. However, there is limited, unclear evidence from observational studies concerning the impact of introducing 3-month or risk-based deferrals.
Keywords
donor selection, deferral, men who have sex with men, transfusion-transmissible infections, C VIRUS-INFECTION, RESIDUAL RISK, HEPATITIS-B, NO EVIDENCE, HIV, IMPACT, PREVALENCE, ANTIBODIES, DISEASE, HBV

Downloads

  • (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 744.64 KB
  • Schroyens 2023 MSM and blood donation Accepted version website.docx
    • full text (Accepted manuscript)
    • |
    • open access
    • |
    • Word
    • |
    • 657.69 KB

Citation

Please use this url to cite or link to this publication:

MLA
Schroyens, Natalie, et al. “Men Who Have Sex with Men and Risk for Transfusion-Transmissible Infections in Blood Donors in Western Countries : A Systematic Review Update.” VOX SANGUINIS, vol. 118, no. 9, 2023, pp. 709–20, doi:10.1111/vox.13482.
APA
Schroyens, N., Borra, V., Compernolle, V., Vandekerckhove, P., & De Buck, E. (2023). Men who have sex with men and risk for transfusion-transmissible infections in blood donors in Western countries : a systematic review update. VOX SANGUINIS, 118(9), 709–720. https://doi.org/10.1111/vox.13482
Chicago author-date
Schroyens, Natalie, Vere Borra, Veerle Compernolle, Philippe Vandekerckhove, and Emmy De Buck. 2023. “Men Who Have Sex with Men and Risk for Transfusion-Transmissible Infections in Blood Donors in Western Countries : A Systematic Review Update.” VOX SANGUINIS 118 (9): 709–20. https://doi.org/10.1111/vox.13482.
Chicago author-date (all authors)
Schroyens, Natalie, Vere Borra, Veerle Compernolle, Philippe Vandekerckhove, and Emmy De Buck. 2023. “Men Who Have Sex with Men and Risk for Transfusion-Transmissible Infections in Blood Donors in Western Countries : A Systematic Review Update.” VOX SANGUINIS 118 (9): 709–720. doi:10.1111/vox.13482.
Vancouver
1.
Schroyens N, Borra V, Compernolle V, Vandekerckhove P, De Buck E. Men who have sex with men and risk for transfusion-transmissible infections in blood donors in Western countries : a systematic review update. VOX SANGUINIS. 2023;118(9):709–20.
IEEE
[1]
N. Schroyens, V. Borra, V. Compernolle, P. Vandekerckhove, and E. De Buck, “Men who have sex with men and risk for transfusion-transmissible infections in blood donors in Western countries : a systematic review update,” VOX SANGUINIS, vol. 118, no. 9, pp. 709–720, 2023.
@article{01HK76T5YCDM0NPT7NBZ6D5H8M,
  abstract     = {{Background and Objectives: This systematic review update summarizes evidence concerning transfusion-transmissible infections (TTIs) in male blood donors reporting sex with another man (MSM) or after easing the MSM deferral period. 

Materials and Methods: We searched five databases, including studies comparing MSM versus non-MSM donors (Type I), MSM deferral periods (Type II) or infected versus non-infected donors (Type III) in Western countries, and used GRADE to determine evidence certainty. 

Results: Twenty-five observational studies were included. Four Type I studies suggest that there may be an increased risk for overall TTIs, human immunodeficiency virus (HIV), hepatitis B virus (HBV) and syphilis in MSM donors, but the evidence is very uncertain. There was insufficient evidence of MSM with low-risk sexual behaviour. A Type II study indicates that easing the MSM deferral period to 1 year may have little to no effect on TTI risk. TTI prevalence in blood donors under 5-year, 1-year, 3-month or risk-based deferral in eight other Type II studies was too low to provide clear conclusions on the effect of easing the deferral. Three Type III studies reported that MSM may be a risk factor for HIV. Increased risk of HBV, hepatitis C virus and HTLV-I/II could not be shown. The evidence from Type III studies is very uncertain. 

Conclusion: There may be an increased risk of HIV in MSM blood donors. Shortening the deferral from permanent to 1 year may have little to no effect on TTI risk. However, there is limited, unclear evidence from observational studies concerning the impact of introducing 3-month or risk-based deferrals.}},
  author       = {{Schroyens, Natalie and  Borra, Vere and Compernolle, Veerle and  Vandekerckhove, Philippe and  De Buck, Emmy}},
  issn         = {{0042-9007}},
  journal      = {{VOX SANGUINIS}},
  keywords     = {{donor selection,deferral,men who have sex with men,transfusion-transmissible infections,C VIRUS-INFECTION,RESIDUAL RISK,HEPATITIS-B,NO EVIDENCE,HIV,IMPACT,PREVALENCE,ANTIBODIES,DISEASE,HBV}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{709--720}},
  title        = {{Men who have sex with men and risk for transfusion-transmissible infections in blood donors in Western countries : a systematic review update}},
  url          = {{http://doi.org/10.1111/vox.13482}},
  volume       = {{118}},
  year         = {{2023}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: