@article{01HJ3N5ANRA583MECH3DJ97VVG,
  abstract     = {{ZBP1 is an innate immune sensor for double-stranded nucleic acids adopting the Z conformation. Z-RNA/DNA is generated during viral infections and in autoinflammation and cancer. By inducing regulated cell death and proinflammatory signaling, ZBP1 plays multifaceted roles in disease pathology.

 Nucleic acid sensing is a central process in the immune system, with far-reaching roles in antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor for double-stranded DNA and RNA helices in the unusual left-handed Z conformation termed Z-DNA and Z-RNA. Recent research established ZBP1 as a key upstream regulator of cell death and proinflammatory signaling. Recognition of Z-DNA/RNA by ZBP1 promotes host resistance to viral infection but can also drive detrimental autoinflammation. Additionally, ZBP1 has interesting roles in cancer and other disease settings and is emerging as an attractive target for therapy.}},
  articleno    = {{e20221156}},
  author       = {{Maelfait, Jonathan and  Rehwinkel, Jan}},
  issn         = {{0022-1007}},
  journal      = {{JOURNAL OF EXPERIMENTAL MEDICINE}},
  keywords     = {{DNA-DEPENDENT ACTIVATOR,INNATE IMMUNE-RESPONSES,IFN-REGULATORY FACTORS,DOUBLE-STRANDED-RNA,BINDING DOMAIN,DAI DLM-1/ZBP1,PROTEIN,NECROPTOSIS,CYTOMEGALOVIRUS,INHIBITION}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{12}},
  title        = {{The Z-nucleic acid sensor ZBP1 in health and disease}},
  url          = {{http://doi.org/10.1084/jem.20221156}},
  volume       = {{220}},
  year         = {{2023}},
}

Altmetric

View in Altmetric

Web of Science

Times cited: