@article{01HHYSFT55Z66PAF1W3ERACBRK,
  abstract     = {{Background To date, azoles represent the only viable option for oral treatment of invasive Candida infections, while rates of azole resistance among non-albicans Candida spp. continue to increase. The objective of this sub-analysis of the European multicenter observational cohort study Candida III was to describe demographical and clinical characteristics of the cohort requiring prolonged hospitalization solely to complete intravenous (iv) antifungal treatment (AF Tx).

Methods Each participating hospital (number of eligible hospitals per country determined by population size) included the first * 10 blood culture proven adult candidemia cases occurring consecutively after July 1st, 2018, and treating physicians answered the question on whether hospital stay was prolonged only for completion of intravenous antifungal therapy. Descriptive analyses as well as binary logistic regression was used to assess for predictors of prolonged hospitalization solely to complete iv AF Tx.

Findings Hospital stay was prolonged solely for the completion of iv AF Tx in 16% (100/621) of candidemia cases by a median of 16 days (IQR 8 - 28). In the multivariable model, initial echinocandin treatment was a positive predictor for prolonged hospitalization to complete iv AF Tx (aOR 2.87, 95% CI 1.55 - 5.32, p < 0.001), while (i) neutropenia, (ii) intensive care unit admission, (iii) catheter related candidemia, (iv) total parenteral nutrition, and (v) C. parapsilosis as causative pathogen were found to be negative predictors (aOR 0.22 - 0.45; p < 0.03).

Interpretation Hospital stays were prolonged due to need of iv AF Tx in 16% of patients with candidemia. Those patients were more likely to receive echinocandins as initial treatment and were less severely ill and less likely infected with C. parapsilosis.}},
  author       = {{Egger, Matthias and Salmanton-García, Jon and Barac, Aleksandra and Gangneux, Jean-Pierre and Guegan, Hélène and Arsic-Arsenijevic, Valentina and Matos, Tadeja and Tomazin, Rok and Klimko, Nikolai and Bassetti, Matteo and Hammarström, Helena and Meijer, Eelco F. J. and Meis, Jacques F. and Prattes, Juergen and Krause, Robert and Resat Sipahi, Oguz and Scharmann, Ulrike and White, P. Lewis and Desoubeaux, Guillaume and García-Rodríguez, Julio and Garcia-Vidal, Carolina and Martín-Pérez, Sonia and Ruiz, Maite and Tumbarello, Mario and Talento, Alida Fe and Rogers, Benedict and Lagrou, Katrien and Van Praet, Jens and Arikan-Akdagli, Sevtap and Arendrup, Maiken C. and Koehler, Philipp and Cornely, Oliver A. and Hoenigl, Martin and Alastruey-Izquierdo, Ana and de Jonge, Nick Alexander and Bicanic, Tihana and Blennow, Ola and Denis, Blandine and Khanna, Nina and Lass-Flörl, Cornelia and Logan, Clare and Loughlin, Laura and Özenci, Volkan and Zdenek, Zdenek and Rahimli, Laman and Rautemaa-Richardson, Riina and Steinmann, Joerg and Stoma, Igor and Trauth, Janina and Danion, François and Buil, Jochem B. and Dávila-Valls, Julio and van Wijngaerden, Eric and on behalf of the ECMM Candida III Study Group$, [missing]}},
  issn         = {{0301-486X}},
  journal      = {{MYCOPATHOLOGIA}},
  keywords     = {{Veterinary (miscellaneous),Agronomy and Crop Science,Applied Microbiology and Biotechnology,Microbiology,Mortality,Candida glabrata,Candida parapsilosis,Candida albicans,Candida auris,Candida tropicalis}},
  language     = {{eng}},
  pages        = {{983--994}},
  publisher    = {{Springer Science and Business Media LLC}},
  title        = {{Predictors for prolonged hospital stay solely to complete intravenous antifungal treatment in patients with candidemia : results from the ECMM Candida III Multinational European Observational Cohort Study}},
  url          = {{http://doi.org/10.1007/s11046-023-00776-4}},
  volume       = {{188}},
  year         = {{2023}},
}

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