@article{01HHYSC82Q0J9KMH50ARBWF8KS,
  abstract     = {{Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent coronavirus (20)19 disease (COVID-19)-related death. The changing epidemiological and therapeutic scenarios suggest that there has been an improvement in severity and survival of COVID-19 during the different waves of the pandemic in the general population, but this has not been investigated yet in MM patients. Here we analyzed a large cohort of 1221 patients with MM and confirmed SARS-CoV-2 infection observed between February 2020, and August 2022, in the EPICOVIDEHA registry from 132 centers around the world. Median follow-up was 52 days for the entire cohort and 83 days for survivors. Three-hundred and three patients died (24%) and COVID-19 was the primary reason for death of around 89% of them. Overall survival (OS) was significantly higher in vaccinated patients with both stable and active MM versus unvaccinated, while only a trend favoring vaccinated patients was observed in subjects with responsive MM. Vaccinated patients with at least 2 doses showed a better OS than those with one or no vaccine dose. Overall, according to pandemic waves, mortality rate decreased over time from 34% to 10%. In multivariable analysis, age, renal failure, active disease, hospital, and intensive care unit admission, were independently associated with a higher number of deaths, while a neutrophil count above 0.5 x 109/L was found to be protective. This data suggests that MM patients remain at risk of SARS-CoV-2 infection even in the vaccination era, but their clinical outcome, in terms of OS, has progressively improved throughout the different viral phases of the pandemic.}},
  articleno    = {{e3240}},
  author       = {{Musto, Pellegrino and Salmanton‐García, Jon and Sgherza, Nicola and Bergantim, Rui and Farina, Francesca and Glenthøj, Andreas and Cengiz Seval, Guldane and Weinbergerová, Barbora and Bonuomo, Valentina and Bilgin, Yavuz M. and van Doesum, Jaap and Jaksic, Ozren and Víšek, Benjamín and Falces‐Romero, Iker and Marchetti, Monia and Dávila‐Valls, Julio and Martín‐Pérez, Sonia and Nucci, Marcio and López‐García, Alberto and Itri, Federico and Buquicchio, Caterina and Verga, Luisa and Piukovics, Klára and Navrátil, Milan and Collins, Graham P. and Jiménez, Moraima and Fracchiolla, Nicola S. and Labrador, Jorge and Prezioso, Lucia and Rossi, Elena and Čolović, Natasha and Meers, Stef and Kulasekararaj, Austin and Cuccaro, Annarosa and Blennow, Ola and Valković, Toni and Sili, Uluhan and Ledoux, Marie‐Pierre and Batinić, Josip and Passamonti, Francesco and Machado, Marina and Duarte, Rafael F. and Poulsen, Christian Bjørn and Méndez, Gustavo‐Adolfo and Espigado, Ildefonso and Demirkan, Fatih and Čerňan, Martin and Cattaneo, Chiara and Petzer, Verena and Magliano, Gabriele and Garcia‐Vidal, Carolina and El‐Ashwah, Shaimaa and Gomes‐Da‐Silva, Maria and Vena, Antonio and Ormazabal‐Vélez, Irati and Van Praet, Jens and Dargenio, Michelina and De‐Ramón, Cristina and Del Principe, Maria Ilaria and Marques‐De‐Almeida, Joyce and Wolf, Dominik and Szotkowski, Tomáš and Obr, Aleš and Çolak, Gökçe Melis and Nordlander, Anna and Izuzquiza, Macarena and Cabirta, Alba and Zambrotta, Giovanni Paolo Maria and Cordoba, Raul and Žák, Pavel and Ammatuna, Emanuele and Mayer, Jiří and Ilhan, Osman and García‐Sanz, Ramón and Quattrone, Martina and Arellano, Elena and Nunes‐Rodrigues, Raquel and Emarah, Ziad and Aiello, Tommaso Francesco and Hanakova, Michaela and Ráčil, Zdeněk and Bavastro, Martina and Limongelli, Alessandro and Rahimli, Laman and Marchesi, Francesco and Cornely, Oliver A. and Pagano, Livio}},
  issn         = {{0278-0232}},
  journal      = {{HEMATOLOGICAL ONCOLOGY}},
  keywords     = {{Cancer Research,Oncology,Hematology,General Medicine,SARS-CoV-2,multiple myeloma,hematological malignancy,COVID-19,CELL TRANSPLANTATION,VACCINATION,RESPONSES}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{15}},
  title        = {{Survival in multiple myeloma and SARS‐COV‐2 infection through the COVID‐19 pandemic : results from the epicovideha registry}},
  url          = {{http://doi.org/10.1002/hon.3240}},
  volume       = {{42}},
  year         = {{2024}},
}

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