Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology
- Author
- Junhua Xie, Arnout Bruggeman (UGent) , Clint De Nolf (UGent) , Charysse Vandendriessche (UGent) , Griet Van Imschoot (UGent) , Elien Van Wonterghem (UGent) , Lars Vereecke (UGent) and Roosmarijn Vandenbroucke (UGent)
- Organization
- Project
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- Unraveling the heterogeneity of the choroid plexus tissue and its cell (sub)type-specific response to different inflammatory triggers.
- A profound study of gut homeostasis in Parkinson's disease.
- Investigating the biomarker potential and pathological role of extracellular vesicles in Parkinson’s disease.
- Abstract
- Accumulating evidence indicates that gut microbiota dysbiosis is associated with increased blood-brain barrier (BBB) permeability and contributes to Alzheimer's disease (AD) pathogenesis. In contrast, the influence of gut microbiota on the blood-cerebrospinal fluid (CSF) barrier has not yet been studied. Here, we report that mice lacking gut microbiota display increased blood-CSF barrier permeability associated with disorganized tight junctions (TJs), which can be rescued by recolonization with gut microbiota or supplementation with short-chain fatty acids (SCFAs). Our data reveal that gut microbiota is important not only for the establishment but also for the maintenance of a tight barrier. Also, we report that the vagus nerve plays an important role in this process and that SCFAs can independently tighten the barrier. Administration of SCFAs in App(NL-G-F) mice improved the subcellular localization of TJs at the blood-CSF barrier, reduced the & beta;-amyloid (A & beta;) burden, and affected microglial phenotype. Altogether, our results suggest that modulating the microbiota and administering SCFAs might have therapeutic potential in AD via blood-CSF barrier tightening and maintaining microglial activity and A & beta; clearance.
- Keywords
- vagus nerve, short-chain fatty acids, gut microbiota, blood-cerebrospinal fluid barrier, Alzheimer's disease
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HHHX8Q4G2HZ7232SEXCJ56M5
- MLA
- Xie, Junhua, et al. “Gut Microbiota Regulates Blood-Cerebrospinal Fluid Barrier Function and Aβ Pathology.” EMBO JOURNAL, vol. 42, no. 17, 2023, doi:10.15252/embj.2022111515.
- APA
- Xie, J., Bruggeman, A., De Nolf, C., Vandendriessche, C., Van Imschoot, G., Van Wonterghem, E., … Vandenbroucke, R. (2023). Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology. EMBO JOURNAL, 42(17). https://doi.org/10.15252/embj.2022111515
- Chicago author-date
- Xie, Junhua, Arnout Bruggeman, Clint De Nolf, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Lars Vereecke, and Roosmarijn Vandenbroucke. 2023. “Gut Microbiota Regulates Blood-Cerebrospinal Fluid Barrier Function and Aβ Pathology.” EMBO JOURNAL 42 (17). https://doi.org/10.15252/embj.2022111515.
- Chicago author-date (all authors)
- Xie, Junhua, Arnout Bruggeman, Clint De Nolf, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Lars Vereecke, and Roosmarijn Vandenbroucke. 2023. “Gut Microbiota Regulates Blood-Cerebrospinal Fluid Barrier Function and Aβ Pathology.” EMBO JOURNAL 42 (17). doi:10.15252/embj.2022111515.
- Vancouver
- 1.Xie J, Bruggeman A, De Nolf C, Vandendriessche C, Van Imschoot G, Van Wonterghem E, et al. Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology. EMBO JOURNAL. 2023;42(17).
- IEEE
- [1]J. Xie et al., “Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology,” EMBO JOURNAL, vol. 42, no. 17, 2023.
@article{01HHHX8Q4G2HZ7232SEXCJ56M5,
abstract = {{Accumulating evidence indicates that gut microbiota dysbiosis is associated with increased blood-brain barrier (BBB) permeability and contributes to Alzheimer's disease (AD) pathogenesis. In contrast, the influence of gut microbiota on the blood-cerebrospinal fluid (CSF) barrier has not yet been studied. Here, we report that mice lacking gut microbiota display increased blood-CSF barrier permeability associated with disorganized tight junctions (TJs), which can be rescued by recolonization with gut microbiota or supplementation with short-chain fatty acids (SCFAs). Our data reveal that gut microbiota is important not only for the establishment but also for the maintenance of a tight barrier. Also, we report that the vagus nerve plays an important role in this process and that SCFAs can independently tighten the barrier. Administration of SCFAs in App(NL-G-F) mice improved the subcellular localization of TJs at the blood-CSF barrier, reduced the & beta;-amyloid (A & beta;) burden, and affected microglial phenotype. Altogether, our results suggest that modulating the microbiota and administering SCFAs might have therapeutic potential in AD via blood-CSF barrier tightening and maintaining microglial activity and A & beta; clearance.}},
articleno = {{e111515}},
author = {{Xie, Junhua and Bruggeman, Arnout and De Nolf, Clint and Vandendriessche, Charysse and Van Imschoot, Griet and Van Wonterghem, Elien and Vereecke, Lars and Vandenbroucke, Roosmarijn}},
issn = {{0261-4189}},
journal = {{EMBO JOURNAL}},
keywords = {{vagus nerve,short-chain fatty acids,gut microbiota,blood-cerebrospinal fluid barrier,Alzheimer's disease}},
language = {{eng}},
number = {{17}},
pages = {{19}},
title = {{Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology}},
url = {{http://doi.org/10.15252/embj.2022111515}},
volume = {{42}},
year = {{2023}},
}
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