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Designing of gradient scaffolds and their applications in tissue regeneration

(2023) BIOMATERIALS. 296.
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Abstract
Gradient scaffolds are isotropic/anisotropic three-dimensional structures with gradual transitions in geometry, density, porosity, stiffness, etc., that mimic the biological extracellular matrix. The gradient structures in bio-logical tissues play a major role in various functional and metabolic activities in the body. The designing of gradients in the scaffold can overcome the current challenges in the clinic compared to conventional scaffolds by exhibiting excellent penetration capacity for nutrients & cells, increased cellular adhesion, cell viability & dif-ferentiation, improved mechanical stability, and biocompatibility. In this review, the recent advancements in designing gradient scaffolds with desired biomimetic properties, and their implication in tissue regeneration applications have been briefly explained. Furthermore, the gradients in native tissues such as bone, cartilage, neuron, cardiovascular, skin and their specific utility in tissue regeneration have been discussed in detail. The insights from such advances using gradient-based scaffolds can widen the horizon for using gradient biomaterials in tissue regeneration applications.
Keywords
Gradient, Scaffolds, Biocompatibility, Extracellular matrix, Tissue regeneration, INDUCED PHASE-SEPARATION, NANOFIBER SCAFFOLDS, ARTICULAR-CARTILAGE, POLYMER SCAFFOLDS, BIOMEDICAL APPLICATIONS, IMMOBILIZED GRADIENTS, MINERAL-CONTENT, CELL-DENSITY, 3D SCAFFOLDS, PORE-SIZE

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MLA
Pattnaik, Ananya, et al. “Designing of Gradient Scaffolds and Their Applications in Tissue Regeneration.” BIOMATERIALS, vol. 296, 2023, doi:10.1016/j.biomaterials.2023.122078.
APA
Pattnaik, A., Sanket, A. S., Pradhan, S., Sahoo, R., Das, S., Pany, S., … Samal, S. K. (2023). Designing of gradient scaffolds and their applications in tissue regeneration. BIOMATERIALS, 296. https://doi.org/10.1016/j.biomaterials.2023.122078
Chicago author-date
Pattnaik, Ananya, A. Swaroop Sanket, Sanghamitra Pradhan, Rajashree Sahoo, Sudiptee Das, Swarnaprbha Pany, Timothy E. L. Douglas, et al. 2023. “Designing of Gradient Scaffolds and Their Applications in Tissue Regeneration.” BIOMATERIALS 296. https://doi.org/10.1016/j.biomaterials.2023.122078.
Chicago author-date (all authors)
Pattnaik, Ananya, A. Swaroop Sanket, Sanghamitra Pradhan, Rajashree Sahoo, Sudiptee Das, Swarnaprbha Pany, Timothy E. L. Douglas, Rambabu Dandela, Qiang Liu, Jaykumar Rajadas, Sanghamitra Pati, Stefaan De Smedt, Kevin Braeckmans, and Sangram Keshari Samal. 2023. “Designing of Gradient Scaffolds and Their Applications in Tissue Regeneration.” BIOMATERIALS 296. doi:10.1016/j.biomaterials.2023.122078.
Vancouver
1.
Pattnaik A, Sanket AS, Pradhan S, Sahoo R, Das S, Pany S, et al. Designing of gradient scaffolds and their applications in tissue regeneration. BIOMATERIALS. 2023;296.
IEEE
[1]
A. Pattnaik et al., “Designing of gradient scaffolds and their applications in tissue regeneration,” BIOMATERIALS, vol. 296, 2023.
@article{01HGJB7EWFMNCV8V5EMPR7XQYX,
  abstract     = {{Gradient scaffolds are isotropic/anisotropic three-dimensional structures with gradual transitions in geometry, density, porosity, stiffness, etc., that mimic the biological extracellular matrix. The gradient structures in bio-logical tissues play a major role in various functional and metabolic activities in the body. The designing of gradients in the scaffold can overcome the current challenges in the clinic compared to conventional scaffolds by exhibiting excellent penetration capacity for nutrients & cells, increased cellular adhesion, cell viability & dif-ferentiation, improved mechanical stability, and biocompatibility. In this review, the recent advancements in designing gradient scaffolds with desired biomimetic properties, and their implication in tissue regeneration applications have been briefly explained. Furthermore, the gradients in native tissues such as bone, cartilage, neuron, cardiovascular, skin and their specific utility in tissue regeneration have been discussed in detail. The insights from such advances using gradient-based scaffolds can widen the horizon for using gradient biomaterials in tissue regeneration applications.}},
  articleno    = {{122078}},
  author       = {{Pattnaik, Ananya and Sanket, A. Swaroop and Pradhan, Sanghamitra and Sahoo, Rajashree and Das, Sudiptee and Pany, Swarnaprbha and Douglas, Timothy E. L. and Dandela, Rambabu and Liu, Qiang and Rajadas, Jaykumar and Pati, Sanghamitra and De Smedt, Stefaan and Braeckmans, Kevin and Samal, Sangram Keshari}},
  issn         = {{0142-9612}},
  journal      = {{BIOMATERIALS}},
  keywords     = {{Gradient,Scaffolds,Biocompatibility,Extracellular matrix,Tissue regeneration,INDUCED PHASE-SEPARATION,NANOFIBER SCAFFOLDS,ARTICULAR-CARTILAGE,POLYMER SCAFFOLDS,BIOMEDICAL APPLICATIONS,IMMOBILIZED GRADIENTS,MINERAL-CONTENT,CELL-DENSITY,3D SCAFFOLDS,PORE-SIZE}},
  language     = {{eng}},
  pages        = {{34}},
  title        = {{Designing of gradient scaffolds and their applications in tissue regeneration}},
  url          = {{http://doi.org/10.1016/j.biomaterials.2023.122078}},
  volume       = {{296}},
  year         = {{2023}},
}

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