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The human inflammasomes

Oonagh Paerewijck (UGent) and Mohamed Lamkanfi (UGent)
(2022) MOLECULAR ASPECTS OF MEDICINE. 88.
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Abstract
Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mech-anisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and their regulation mechanisms, including an expansion of inflammasome biology to adaptive immune cells. These exciting developments in basic research have been accompanied by potentially transformative results from large clinical trials and translational efforts to develop inflammasome-targeted small molecule inhibitors for therapeutic use. Here, we will discuss recent findings in the field with a specific emphasis on activation mechanisms of human inflammasomes and their potential role in auto-inflammatory, metabolic and neoplastic diseases.
Keywords
Inflammasome, Caspase, Cell death, Inflammation, Human disease, Pyroptosis, NLRP3 INFLAMMASOME, ACTIVATION DOWNSTREAM, GASDERMIN D, CELL-DEATH, CASPASES, PYRIN, NEK7, PHOSPHORYLATION, SUSCEPTIBILITY, REQUIREMENT

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Citation

Please use this url to cite or link to this publication:

MLA
Paerewijck, Oonagh, and Mohamed Lamkanfi. “The Human Inflammasomes.” MOLECULAR ASPECTS OF MEDICINE, vol. 88, 2022, doi:10.1016/j.mam.2022.101100.
APA
Paerewijck, O., & Lamkanfi, M. (2022). The human inflammasomes. MOLECULAR ASPECTS OF MEDICINE, 88. https://doi.org/10.1016/j.mam.2022.101100
Chicago author-date
Paerewijck, Oonagh, and Mohamed Lamkanfi. 2022. “The Human Inflammasomes.” MOLECULAR ASPECTS OF MEDICINE 88. https://doi.org/10.1016/j.mam.2022.101100.
Chicago author-date (all authors)
Paerewijck, Oonagh, and Mohamed Lamkanfi. 2022. “The Human Inflammasomes.” MOLECULAR ASPECTS OF MEDICINE 88. doi:10.1016/j.mam.2022.101100.
Vancouver
1.
Paerewijck O, Lamkanfi M. The human inflammasomes. MOLECULAR ASPECTS OF MEDICINE. 2022;88.
IEEE
[1]
O. Paerewijck and M. Lamkanfi, “The human inflammasomes,” MOLECULAR ASPECTS OF MEDICINE, vol. 88, 2022.
@article{01HGGK2964KSB7M8W3FR5GY99S,
  abstract     = {{Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mech-anisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and their regulation mechanisms, including an expansion of inflammasome biology to adaptive immune cells. These exciting developments in basic research have been accompanied by potentially transformative results from large clinical trials and translational efforts to develop inflammasome-targeted small molecule inhibitors for therapeutic use. Here, we will discuss recent findings in the field with a specific emphasis on activation mechanisms of human inflammasomes and their potential role in auto-inflammatory, metabolic and neoplastic diseases.}},
  articleno    = {{101100}},
  author       = {{Paerewijck, Oonagh and Lamkanfi, Mohamed}},
  issn         = {{0098-2997}},
  journal      = {{MOLECULAR ASPECTS OF MEDICINE}},
  keywords     = {{Inflammasome,Caspase,Cell death,Inflammation,Human disease,Pyroptosis,NLRP3 INFLAMMASOME,ACTIVATION DOWNSTREAM,GASDERMIN D,CELL-DEATH,CASPASES,PYRIN,NEK7,PHOSPHORYLATION,SUSCEPTIBILITY,REQUIREMENT}},
  language     = {{eng}},
  pages        = {{11}},
  title        = {{The human inflammasomes}},
  url          = {{http://doi.org/10.1016/j.mam.2022.101100}},
  volume       = {{88}},
  year         = {{2022}},
}
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