@article{01HG0HB85Z7Z06KZFCXF6RDR59,
  abstract     = {{Intra-  and transdermal administration of substances via percutaneous injection is effec-tive but considered painful, and inconvenient in addition to bringing forth biohazardous waste  material.  In  contrast  to  injection,  topical  drug  application,  which  includes  oint-ments, creams and lotions, increases the local drug load. Moreover, it has reduced side effects compared to systemic administration. However, the epidermis poses a barrier to high molecular weight substances, limiting the delivery efficiency. Dissolving micronee-dles  (DMN)  are  hydrophilic,  mostly  polymer-  based  constructs  that  are  capable  of  skin  penetration and were developed to provide painless and direct dermal drug delivery. This systematic review provides a comprehensive overview of the available clinical evidence for the use of DMN to treat various skin conditions. According to the PRISMA statement, a  systematic  search  for  articles  on  the  use  of  DMN  for  dermatological  indications  was  conducted  on  three  different  databases  (Pubmed,  Embase,  and  the  Cochrane  library).  Only human clinical trials were considered. Qualitative assessment was done by two sep-arate reviewers using the Cochrane risk of bias (RoB 2) and Chambers' criteria assessment tools. The search yielded 1090 articles. After deduplication and removal of ineligible re-cords,  889  records  were  screened  on  title  and  abstract.  Full  text  screening  was  done  for  18  articles  and  ultimately  17  articles  were  included  of  which  15  were  randomized  controlled trials and two were case series. The quality assessment showed that the ma-jority of included studies had low to no risk of bias. Clinical data supports that DMN are an  excellent,  effective,  and  pain  free  drug  delivery  method  for  multiple  dermatological  disorders  including  skin  aging,  hyperpigmentation,  psoriasis,  warts,  and  keloids  by  sup-plying a painless and effective vehicle for intradermal/intralesional drug administration. Microneedle  technology  provides  a  promising  non-    to  minimally-invasive  alternative  to  percutaneous injection.KEYWORDSdermatology, dissolving, drug delivery, microneedles, microneedles, systematic review}},
  author       = {{De Decker, Ignace and Logé, Thomas and Hoeksema, Hendrik and Speeckaert, Marijn and Blondeel, Philippe and Monstrey, Stan and Claes, Karel}},
  issn         = {{0385-2407}},
  journal      = {{JOURNAL OF DERMATOLOGY}},
  keywords     = {{systematic review,microneedles,drug delivery,dissolving,dermatology}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{422--444}},
  title        = {{Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions : a systematic review}},
  url          = {{http://doi.org/10.1111/1346-8138.16732}},
  volume       = {{50}},
  year         = {{2023}},
}

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