A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs
- Author
- Benjamin Cappe, Peter Vandenabeele (UGent) and Franck Riquet (UGent)
- Organization
- Project
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- Factors that determine RIPK1-dependent necroptosis
- Investigating the role of ferroptosis in acute liver injury and multiple sclerosis with newly developed chemical tool compounds
- MOlecular mechanisms of cellular DEath and Life decisions in Inflammation, Degeneration and Infection
- Cell Death Regulation and Role in Infection and Inflammatory Diseases
- Cell death activity regulation in inflammation and cancer
- Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy
- Cell death modality regulation during immunotherapy (CREDIT): molecular mechanisms and experimental therapy.
- Improving cancer therapy by modulating cell death and the microbiome in the gut
- Abstract
- Homeostasis disruption is visible at the molecular and cellular levels and may often lead to cell death. This vital process allows us to maintain the more extensive system's integrity by keeping the different features (genetic, metabolic, physiologic, and individual) intact. Interestingly, while cells can die in different manners, dying cells still communicate with their environment. This communication was, for a long time, perceived as only driven by the release of soluble factors. However, it has now been reconsidered with the increasing interest in extracellular vesicles (EVs), which are discovered to be released during different regulated cell death programs, with the observation of specific effects. EVs are game changers in the paradigm of cell-cell communication with tremendous implications in fundamental research with regard to noncell autonomous functions, as well as in biomarkers research, all of which are geared toward diagnostic and therapeutic purposes. This review is composed of two main parts. The first is a comprehensive presentation of the state of the art of the EV field at large. In the second part, we focus on EVs discovered to be released during different regulated cell death programs, also known as cell death EVs (cdEVs), and EV-associated specific effects on recipient cells in the context of cell death and inflammation/inflammatory responses. Extracellular vesicles (EVs) are game changers in the paradigm of cell-cell communication with tremendous implications in fundamental research. This review is a comprehensive presentation of the state of the art of the EV field at large, with a focus on EVs released during different regulated cell death programs, also known as cell death EVs (cdEVs), and EV-associated specific effects on recipient cells in the context of cell death and inflammation.image
- Keywords
- apoptosis, apoptotic bodies, cdEVs, cell death programs, exosomes, extracellular vesicles, ferroptosis, microvesicles, necroptosis, pyroptosis, MIXED LINEAGE KINASE, DENDRITIC CELLS, GASDERMIN D, TRANSFERRIN RECEPTOR, MEMBRANE VESICLES, DOMAIN-LIKE, IN-VITRO, APOPTOSIS, EXOSOMES, NECROSIS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HFXRE7DNZAS6P6TC70AJZGS7
- MLA
- Cappe, Benjamin, et al. “A Guide to the Expanding Field of Extracellular Vesicles and Their Release in Regulated Cell Death Programs.” FEBS JOURNAL, vol. 291, no. 10, 2024, pp. 2068–90, doi:10.1111/febs.16981.
- APA
- Cappe, B., Vandenabeele, P., & Riquet, F. (2024). A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs. FEBS JOURNAL, 291(10), 2068–2090. https://doi.org/10.1111/febs.16981
- Chicago author-date
- Cappe, Benjamin, Peter Vandenabeele, and Franck Riquet. 2024. “A Guide to the Expanding Field of Extracellular Vesicles and Their Release in Regulated Cell Death Programs.” FEBS JOURNAL 291 (10): 2068–90. https://doi.org/10.1111/febs.16981.
- Chicago author-date (all authors)
- Cappe, Benjamin, Peter Vandenabeele, and Franck Riquet. 2024. “A Guide to the Expanding Field of Extracellular Vesicles and Their Release in Regulated Cell Death Programs.” FEBS JOURNAL 291 (10): 2068–2090. doi:10.1111/febs.16981.
- Vancouver
- 1.Cappe B, Vandenabeele P, Riquet F. A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs. FEBS JOURNAL. 2024;291(10):2068–90.
- IEEE
- [1]B. Cappe, P. Vandenabeele, and F. Riquet, “A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs,” FEBS JOURNAL, vol. 291, no. 10, pp. 2068–2090, 2024.
@article{01HFXRE7DNZAS6P6TC70AJZGS7,
abstract = {{Homeostasis disruption is visible at the molecular and cellular levels and may often lead to cell death. This vital process allows us to maintain the more extensive system's integrity by keeping the different features (genetic, metabolic, physiologic, and individual) intact. Interestingly, while cells can die in different manners, dying cells still communicate with their environment. This communication was, for a long time, perceived as only driven by the release of soluble factors. However, it has now been reconsidered with the increasing interest in extracellular vesicles (EVs), which are discovered to be released during different regulated cell death programs, with the observation of specific effects. EVs are game changers in the paradigm of cell-cell communication with tremendous implications in fundamental research with regard to noncell autonomous functions, as well as in biomarkers research, all of which are geared toward diagnostic and therapeutic purposes. This review is composed of two main parts. The first is a comprehensive presentation of the state of the art of the EV field at large. In the second part, we focus on EVs discovered to be released during different regulated cell death programs, also known as cell death EVs (cdEVs), and EV-associated specific effects on recipient cells in the context of cell death and inflammation/inflammatory responses.
Extracellular vesicles (EVs) are game changers in the paradigm of cell-cell communication with tremendous implications in fundamental research. This review is a comprehensive presentation of the state of the art of the EV field at large, with a focus on EVs released during different regulated cell death programs, also known as cell death EVs (cdEVs), and EV-associated specific effects on recipient cells in the context of cell death and inflammation.image}},
author = {{Cappe, Benjamin and Vandenabeele, Peter and Riquet, Franck}},
issn = {{1742-464X}},
journal = {{FEBS JOURNAL}},
keywords = {{apoptosis,apoptotic bodies,cdEVs,cell death programs,exosomes,extracellular vesicles,ferroptosis,microvesicles,necroptosis,pyroptosis,MIXED LINEAGE KINASE,DENDRITIC CELLS,GASDERMIN D,TRANSFERRIN RECEPTOR,MEMBRANE VESICLES,DOMAIN-LIKE,IN-VITRO,APOPTOSIS,EXOSOMES,NECROSIS}},
language = {{eng}},
number = {{10}},
pages = {{2068--2090}},
title = {{A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs}},
url = {{http://doi.org/10.1111/febs.16981}},
volume = {{291}},
year = {{2024}},
}
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