Pharmacokinetics of gamma‐hydroxybutyric acid in 6‐week‐old swine (Sus scrofa domesticus) after intravenous and oral administration
- Author
- Charlotte Cuypers (UGent) , Mathias Devreese (UGent) , Katleen Van Uytfanghe (UGent) , Christophe Stove (UGent) and Stijn Schauvliege (UGent)
- Organization
- Abstract
- Sedative as well as protective effects during hypoxia have been described for gamma-hydroxybutyric acid (GHB). Six swine (Sus scrofa domesticus) of 6 weeks old were administered NaGHB at a dose of 500 mg/kg intravenously (IV) and 500 and 750 mg/kg orally (PO) in a triple cross-over design. Repeated blood sampling was performed to allow pharmacokinetic analysis of GHB. Whole blood concentration at time point 0 after IV administration was 1727.21 +/- 280.73 mu g/mL, with a volume of distribution of 339.45 +/- 51.41 mL/kg and clearance of 164.94 +/- 47.05 mL/(kg h). The mean peak plasma concentrations after PO administration were 326.57 +/- 36.70 and 488.01 +/- 154.62 mu g/mL for 500 mg/kg and 750 mg/kg, respectively. These were recorded at 1.42 +/- 0.72 and 1.58 +/- 0.58 h after PO dose for GHB 500 mg/kg and 750 mg/kg, respectively. The elimination half-life for IV and PO 500 mg/kg and PO 750 mg/kg dose was respectively 1.33 +/- 0.30, 1.16 +/- 0.31 and 1.11 +/- 0.33 h. The bioavailability (F) for PO administration was 45%. No clinical adverse effects were observed after PO administration. Deep sleep was seen in one animal after IV administration, other animals showed head pressing and ataxia.
- Keywords
- General Veterinary, Pharmacology, gamma-hydroxybutyric acid, gas chromatography - mass spectrometry, juvenile pigs, pharmacokinetics, sedation, SODIUM OXYBATE, GHB, BLOOD, ELIMINATION, ISCHEMIA, RATS, PHARMACODYNAMICS, BUTYROLACTONE, MECHANISMS, 1ST-ORDER
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HFW6S37QWMAB85MT3WS92W24
- MLA
- Cuypers, Charlotte, et al. “Pharmacokinetics of Gamma‐hydroxybutyric Acid in 6‐week‐old Swine (Sus Scrofa Domesticus) after Intravenous and Oral Administration.” JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, vol. 47, no. 2, 2024, pp. 95–106, doi:10.1111/jvp.13418.
- APA
- Cuypers, C., Devreese, M., Van Uytfanghe, K., Stove, C., & Schauvliege, S. (2024). Pharmacokinetics of gamma‐hydroxybutyric acid in 6‐week‐old swine (Sus scrofa domesticus) after intravenous and oral administration. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 47(2), 95–106. https://doi.org/10.1111/jvp.13418
- Chicago author-date
- Cuypers, Charlotte, Mathias Devreese, Katleen Van Uytfanghe, Christophe Stove, and Stijn Schauvliege. 2024. “Pharmacokinetics of Gamma‐hydroxybutyric Acid in 6‐week‐old Swine (Sus Scrofa Domesticus) after Intravenous and Oral Administration.” JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 47 (2): 95–106. https://doi.org/10.1111/jvp.13418.
- Chicago author-date (all authors)
- Cuypers, Charlotte, Mathias Devreese, Katleen Van Uytfanghe, Christophe Stove, and Stijn Schauvliege. 2024. “Pharmacokinetics of Gamma‐hydroxybutyric Acid in 6‐week‐old Swine (Sus Scrofa Domesticus) after Intravenous and Oral Administration.” JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 47 (2): 95–106. doi:10.1111/jvp.13418.
- Vancouver
- 1.Cuypers C, Devreese M, Van Uytfanghe K, Stove C, Schauvliege S. Pharmacokinetics of gamma‐hydroxybutyric acid in 6‐week‐old swine (Sus scrofa domesticus) after intravenous and oral administration. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. 2024;47(2):95–106.
- IEEE
- [1]C. Cuypers, M. Devreese, K. Van Uytfanghe, C. Stove, and S. Schauvliege, “Pharmacokinetics of gamma‐hydroxybutyric acid in 6‐week‐old swine (Sus scrofa domesticus) after intravenous and oral administration,” JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, vol. 47, no. 2, pp. 95–106, 2024.
@article{01HFW6S37QWMAB85MT3WS92W24,
abstract = {{Sedative as well as protective effects during hypoxia have been described for gamma-hydroxybutyric acid (GHB). Six swine (Sus scrofa domesticus) of 6 weeks old were administered NaGHB at a dose of 500 mg/kg intravenously (IV) and 500 and 750 mg/kg orally (PO) in a triple cross-over design. Repeated blood sampling was performed to allow pharmacokinetic analysis of GHB. Whole blood concentration at time point 0 after IV administration was 1727.21 +/- 280.73 mu g/mL, with a volume of distribution of 339.45 +/- 51.41 mL/kg and clearance of 164.94 +/- 47.05 mL/(kg h). The mean peak plasma concentrations after PO administration were 326.57 +/- 36.70 and 488.01 +/- 154.62 mu g/mL for 500 mg/kg and 750 mg/kg, respectively. These were recorded at 1.42 +/- 0.72 and 1.58 +/- 0.58 h after PO dose for GHB 500 mg/kg and 750 mg/kg, respectively. The elimination half-life for IV and PO 500 mg/kg and PO 750 mg/kg dose was respectively 1.33 +/- 0.30, 1.16 +/- 0.31 and 1.11 +/- 0.33 h. The bioavailability (F) for PO administration was 45%. No clinical adverse effects were observed after PO administration. Deep sleep was seen in one animal after IV administration, other animals showed head pressing and ataxia.}},
author = {{Cuypers, Charlotte and Devreese, Mathias and Van Uytfanghe, Katleen and Stove, Christophe and Schauvliege, Stijn}},
issn = {{0140-7783}},
journal = {{JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS}},
keywords = {{General Veterinary,Pharmacology,gamma-hydroxybutyric acid,gas chromatography - mass spectrometry,juvenile pigs,pharmacokinetics,sedation,SODIUM OXYBATE,GHB,BLOOD,ELIMINATION,ISCHEMIA,RATS,PHARMACODYNAMICS,BUTYROLACTONE,MECHANISMS,1ST-ORDER}},
language = {{eng}},
number = {{2}},
pages = {{95--106}},
title = {{Pharmacokinetics of gamma‐hydroxybutyric acid in 6‐week‐old swine (Sus scrofa domesticus) after intravenous and oral administration}},
url = {{http://doi.org/10.1111/jvp.13418}},
volume = {{47}},
year = {{2024}},
}
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