Environment-functionality-cost balance of an analytical reagent
- Author
- Hannah Hirmz (UGent) , Frederick Verbeke, Bartosz Wielgomas (UGent) , Christophe Furman, Emmanuelle Lipka, Bart De Spiegeleer (UGent) and Evelien Wynendaele (UGent)
- Organization
- Project
- Abstract
- Green chemistry was originally mainly driven by organic synthetic approaches, but green analyt-ics is slowly following, searching for ways to reduce volumes, cost and ecotoxicity of analytically used chemicals and lowering energy usage. The emphasis is currently focussed on techniques such as miniaturization, on-line spectroscopy, or the chemicals directly used in the analytical process, e.g. chromatographic solvents. However, almost no attention has yet been paid to the an-alytical reagents, and more specifically, the way they are produced and used in greening analyt-ics. In the analysis of low level analytes, such as peptides in the biomedical area, a prominent challenge is their possible adsorption to glass or plastic consumables used during analysis. In this research, a recently developed anti-adsorption diluent based on bovine serum albumin, acetoni-trile and formic acid, was investigated towards greener alternatives. The 12 principles of green chemistry were applied, but also the anti-adsorption functionality and cost-efficiency were taken into account to obtain a more holistic sustainability view. A Derringer desirability function was used to convert these 3 aspects into one overall 'fit-for-purpose' score, from which it was con-cluded that replacing acetonitrile by (denatured) ethanol is the most optimal choice, whilst main-taining bovine serum albumin as protein source.
- Keywords
- Management, Monitoring, Policy and Law, Pharmaceutical Science, Pollution, Environmental Chemistry, Green analytical chemistry, Sustainability, Anti-Adsorption solution, Peptidomics, CHROMATOGRAPHY, CHEMISTRY
Downloads
-
(...).pdf
- full text (Published version)
- |
- UGent only
- |
- |
- 1.19 MB
-
Environment-functionality-cost balance of an analytical reagent.pdf
- full text (Accepted manuscript)
- |
- open access
- |
- |
- 1.27 MB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HFVRWNK8MEFVG1CPQ86K2S36
- MLA
- Hirmz, Hannah, et al. “Environment-Functionality-Cost Balance of an Analytical Reagent.” SUSTAINABLE CHEMISTRY AND PHARMACY, vol. 32, 2023, doi:10.1016/j.scp.2023.100973.
- APA
- Hirmz, H., Verbeke, F., Wielgomas, B., Furman, C., Lipka, E., De Spiegeleer, B., & Wynendaele, E. (2023). Environment-functionality-cost balance of an analytical reagent. SUSTAINABLE CHEMISTRY AND PHARMACY, 32. https://doi.org/10.1016/j.scp.2023.100973
- Chicago author-date
- Hirmz, Hannah, Frederick Verbeke, Bartosz Wielgomas, Christophe Furman, Emmanuelle Lipka, Bart De Spiegeleer, and Evelien Wynendaele. 2023. “Environment-Functionality-Cost Balance of an Analytical Reagent.” SUSTAINABLE CHEMISTRY AND PHARMACY 32. https://doi.org/10.1016/j.scp.2023.100973.
- Chicago author-date (all authors)
- Hirmz, Hannah, Frederick Verbeke, Bartosz Wielgomas, Christophe Furman, Emmanuelle Lipka, Bart De Spiegeleer, and Evelien Wynendaele. 2023. “Environment-Functionality-Cost Balance of an Analytical Reagent.” SUSTAINABLE CHEMISTRY AND PHARMACY 32. doi:10.1016/j.scp.2023.100973.
- Vancouver
- 1.Hirmz H, Verbeke F, Wielgomas B, Furman C, Lipka E, De Spiegeleer B, et al. Environment-functionality-cost balance of an analytical reagent. SUSTAINABLE CHEMISTRY AND PHARMACY. 2023;32.
- IEEE
- [1]H. Hirmz et al., “Environment-functionality-cost balance of an analytical reagent,” SUSTAINABLE CHEMISTRY AND PHARMACY, vol. 32, 2023.
@article{01HFVRWNK8MEFVG1CPQ86K2S36,
abstract = {{Green chemistry was originally mainly driven by organic synthetic approaches, but green analyt-ics is slowly following, searching for ways to reduce volumes, cost and ecotoxicity of analytically used chemicals and lowering energy usage. The emphasis is currently focussed on techniques such as miniaturization, on-line spectroscopy, or the chemicals directly used in the analytical process, e.g. chromatographic solvents. However, almost no attention has yet been paid to the an-alytical reagents, and more specifically, the way they are produced and used in greening analyt-ics. In the analysis of low level analytes, such as peptides in the biomedical area, a prominent challenge is their possible adsorption to glass or plastic consumables used during analysis. In this research, a recently developed anti-adsorption diluent based on bovine serum albumin, acetoni-trile and formic acid, was investigated towards greener alternatives. The 12 principles of green chemistry were applied, but also the anti-adsorption functionality and cost-efficiency were taken into account to obtain a more holistic sustainability view. A Derringer desirability function was used to convert these 3 aspects into one overall 'fit-for-purpose' score, from which it was con-cluded that replacing acetonitrile by (denatured) ethanol is the most optimal choice, whilst main-taining bovine serum albumin as protein source.}},
articleno = {{100973}},
author = {{Hirmz, Hannah and Verbeke, Frederick and Wielgomas, Bartosz and Furman, Christophe and Lipka, Emmanuelle and De Spiegeleer, Bart and Wynendaele, Evelien}},
issn = {{2352-5541}},
journal = {{SUSTAINABLE CHEMISTRY AND PHARMACY}},
keywords = {{Management, Monitoring, Policy and Law,Pharmaceutical Science,Pollution,Environmental Chemistry,Green analytical chemistry,Sustainability,Anti-Adsorption solution,Peptidomics,CHROMATOGRAPHY,CHEMISTRY}},
language = {{eng}},
pages = {{10}},
title = {{Environment-functionality-cost balance of an analytical reagent}},
url = {{http://doi.org/10.1016/j.scp.2023.100973}},
volume = {{32}},
year = {{2023}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: