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Differential abundance and gene set enrichment in plasma of cancer patients versus controls

(2023)
Author
Organization
Abstract
DESeq2 differential abundance output for genes with q < 0.05 and |log2 fold change| > 1 in cancer vs control plasma samples: - differentialabundance_pancancer.txt: tables with differentially abundant genes (|log2(fold change)|>1 and adjusted p>0.05) per cancer-control comparison (cancertype) in a pan-cancer plasma sample cohort (25 locally advanced to metastatic cancer types - 7 or 8 patients per type - vs 8 cancer-free control donors) - differentialabundance_threecancer.txt: tables with differentially abundant genes (|log2(fold change)|>1 and adjusted p>0.05) per cancer-control comparison (cancertype) in the three-cancer plasma cohort (ovarian, prostate and uterine cancer - 11 or 12 patients per type - vs 20 cancer-free controls) Gene set enrichment analyses based on fold change ranked gene lists (cancer versus control) - results obtained with fgea (v1.22.0): - customgenesets.txt: custom gene set lists based on RNA Atlas (&Human Protein Atlas), Tabula Sapiens, GTEX, TCGA data. - GSEA_pancancer.txt & GSEA_threecancer.txt: gene set enrichment results based on fold change ranked gene list (specific cancer type versus controls) in pan-cancer cohort and three-cancer cohort, respectively
License
CC-BY-4.0
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open access

Citation

Please use this url to cite or link to this publication:

@misc{01HFKR2FQ9J737YEDZDK6P4WQ4,
  abstract     = {{DESeq2 differential abundance output for genes with q < 0.05 and |log2 fold change| > 1 in cancer vs control plasma samples:
- differentialabundance_pancancer.txt: tables with differentially abundant genes (|log2(fold change)|>1 and adjusted p>0.05) per cancer-control comparison (cancertype) in a pan-cancer plasma sample cohort (25 locally advanced to metastatic cancer types - 7 or 8 patients per type - vs 8 cancer-free control donors)
- differentialabundance_threecancer.txt: tables with differentially abundant genes (|log2(fold change)|>1 and adjusted p>0.05) per cancer-control comparison (cancertype) in the three-cancer plasma cohort (ovarian, prostate and uterine cancer - 11 or 12 patients per type - vs 20 cancer-free controls)

Gene set enrichment analyses based on fold change ranked gene lists (cancer versus control) - results obtained with fgea (v1.22.0):
- customgenesets.txt: custom gene set lists based on RNA Atlas (&Human Protein Atlas), Tabula Sapiens, GTEX, TCGA data.
- GSEA_pancancer.txt & GSEA_threecancer.txt: gene set enrichment results based on fold change ranked gene list (specific cancer type versus controls) in pan-cancer cohort and three-cancer cohort, respectively}},
  author       = {{Morlion, Annelien}},
  publisher    = {{Zenodo}},
  title        = {{Differential abundance and gene set enrichment in plasma of cancer patients versus controls}},
  url          = {{http://doi.org/10.5281/ZENODO.7953707}},
  year         = {{2023}},
}

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