CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis
- Author
- Helena Braet (UGent) , Peter-Paul Fransen, Remco Mariën (UGent) , Giovanna Lollo, Wim Ceelen (UGent) , Chris Vervaet (UGent) , Lieve Balcaen (UGent) , Frank Vanhaecke (UGent) , Christian Vanhove (UGent) , Stefan van der Vegte, Elke Gasthuys (UGent) , An Vermeulen (UGent) , Patricia Y.W. Dankers, Stefaan De Smedt (UGent) and Katrien Remaut (UGent)
- Organization
- Project
-
- Intraperitoneal nebulization of thermosensitive hydrogels for the controlled release of chemotherapeutics and biopharmaceuticals to treat peritoneal carcinomatosis
- High pressure intraperitoneal aerosolization of chemotherapeutics, nanoparticles and hydrogels to treat peritoneal carcinomatosis: effect on tumor penetration, biodistribution and anti-cancer activity.
- DeLNAM (Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis)
- Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases
- 3L000109
- Abstract
- Because peritoneal metastasis (PM) from ovarian cancer is characterized by non-specific symptoms, it is often diagnosed at advanced stages. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) can be considered a promising drug delivery method for unresectable PM. Currently, the efficacy of intraperitoneal (IP) drug delivery is limited by the off-label use of IV chemotherapeutic solutions, which are rapidly cleared from the IP cavity. Hence, this research aimed to improve PM treatment by evaluating a nanoparticle-loaded, pH-switchable supramolecular polymer hydrogel as a controlled release drug delivery system that can be IP nebulized. Moreover, a multidirectional nozzle was developed to allow nebulization of viscous materials such as hydrogels and to reach an even IP gel deposition. We demonstrated that acidification of the nebulized hydrogelator solution by carbon dioxide, used to inflate the IP cavity during laparoscopic surgery, stimulated the in situ gelation, which prolonged the IP hydrogel retention. In vitro experiments indicated that paclitaxel nanocrystals were gradually released from the hydrogel depot formed, which sustained the cytotoxicity of the formulation for 10 days. Finally, after aerosolization of this material in a xenograft model of PM, tumor progression could successfully be delayed, while the overall survival time was significantly increased compared to non-treated animals.
- Keywords
- General Materials Science, nanomedicines, nozzle, sustainedrelease, supramolecular hydrogel, sprayable gel, ePIPAC, PIPAC, peritoneal metastasis
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HF6HPNVEC5BY6DDNFV25T4XV
- MLA
- Braet, Helena, et al. “CO2-Driven Nebulization of PH-Sensitive Supramolecular Polymers for Intraperitoneal Hydrogel Formation and the Treatment of Peritoneal Metastasis.” ACS APPLIED MATERIALS & INTERFACES, vol. 15, no. 42, American Chemical Society (ACS), 2023, pp. 49022–34, doi:10.1021/acsami.3c11274.
- APA
- Braet, H., Fransen, P.-P., Mariën, R., Lollo, G., Ceelen, W., Vervaet, C., … Remaut, K. (2023). CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis. ACS APPLIED MATERIALS & INTERFACES, 15(42), 49022–49034. https://doi.org/10.1021/acsami.3c11274
- Chicago author-date
- Braet, Helena, Peter-Paul Fransen, Remco Mariën, Giovanna Lollo, Wim Ceelen, Chris Vervaet, Lieve Balcaen, et al. 2023. “CO2-Driven Nebulization of PH-Sensitive Supramolecular Polymers for Intraperitoneal Hydrogel Formation and the Treatment of Peritoneal Metastasis.” ACS APPLIED MATERIALS & INTERFACES 15 (42): 49022–34. https://doi.org/10.1021/acsami.3c11274.
- Chicago author-date (all authors)
- Braet, Helena, Peter-Paul Fransen, Remco Mariën, Giovanna Lollo, Wim Ceelen, Chris Vervaet, Lieve Balcaen, Frank Vanhaecke, Christian Vanhove, Stefan van der Vegte, Elke Gasthuys, An Vermeulen, Patricia Y.W. Dankers, Stefaan De Smedt, and Katrien Remaut. 2023. “CO2-Driven Nebulization of PH-Sensitive Supramolecular Polymers for Intraperitoneal Hydrogel Formation and the Treatment of Peritoneal Metastasis.” ACS APPLIED MATERIALS & INTERFACES 15 (42): 49022–49034. doi:10.1021/acsami.3c11274.
- Vancouver
- 1.Braet H, Fransen P-P, Mariën R, Lollo G, Ceelen W, Vervaet C, et al. CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis. ACS APPLIED MATERIALS & INTERFACES. 2023;15(42):49022–34.
- IEEE
- [1]H. Braet et al., “CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis,” ACS APPLIED MATERIALS & INTERFACES, vol. 15, no. 42, pp. 49022–49034, 2023.
@article{01HF6HPNVEC5BY6DDNFV25T4XV,
abstract = {{Because peritoneal metastasis (PM) from ovarian cancer is characterized by non-specific symptoms, it is often diagnosed at advanced stages. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) can be considered a promising drug delivery method for unresectable PM. Currently, the efficacy of intraperitoneal (IP) drug delivery is limited by the off-label use of IV chemotherapeutic solutions, which are rapidly cleared from the IP cavity. Hence, this research aimed to improve PM treatment by evaluating a nanoparticle-loaded, pH-switchable supramolecular polymer hydrogel as a controlled release drug delivery system that can be IP nebulized. Moreover, a multidirectional nozzle was developed to allow nebulization of viscous materials such as hydrogels and to reach an even IP gel deposition. We demonstrated that acidification of the nebulized hydrogelator solution by carbon dioxide, used to inflate the IP cavity during laparoscopic surgery, stimulated the in situ gelation, which prolonged the IP hydrogel retention. In vitro experiments indicated that paclitaxel nanocrystals were gradually released from the hydrogel depot formed, which sustained the cytotoxicity of the formulation for 10 days. Finally, after aerosolization of this material in a xenograft model of PM, tumor progression could successfully be delayed, while the overall survival time was significantly increased compared to non-treated animals.}},
author = {{Braet, Helena and Fransen, Peter-Paul and Mariën, Remco and Lollo, Giovanna and Ceelen, Wim and Vervaet, Chris and Balcaen, Lieve and Vanhaecke, Frank and Vanhove, Christian and van der Vegte, Stefan and Gasthuys, Elke and Vermeulen, An and Dankers, Patricia Y.W. and De Smedt, Stefaan and Remaut, Katrien}},
issn = {{1944-8244}},
journal = {{ACS APPLIED MATERIALS & INTERFACES}},
keywords = {{General Materials Science,nanomedicines,nozzle,sustainedrelease,supramolecular hydrogel,sprayable gel,ePIPAC,PIPAC,peritoneal metastasis}},
language = {{eng}},
number = {{42}},
pages = {{49022--49034}},
publisher = {{American Chemical Society (ACS)}},
title = {{CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis}},
url = {{http://doi.org/10.1021/acsami.3c11274}},
volume = {{15}},
year = {{2023}},
}
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