Functions of the RIP kinase family members in the skin
- Author
- Corinne Urwyler (UGent) , Giel Tanghe (UGent) , Michael Devos, Paco Hulpiau (UGent) , Yvan Saeys (UGent) and Wim Declercq (UGent)
- Organization
- Project
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- Identification of RIPK4-dependent signalling pathways and the role of RIPK4 in skin homeostasis and disease
- Cell death activity regulation in inflammation and cancer
- Replacement and extension of basic infrastructure in the histology core facility.
- Purchase steam autoclave central kitchen Department of Biomedical Molecular Biology
- Dissecting the role of RIPK4 in skin cancer
- De BD FACS Symphony FACS cell sorter : de meest geavanceerde multiparameter fluorescentie geactiveerde cell sorter die de indetificatie en purificatie van zeldzame cellen toelaat voor verdere functionele characterisatie
- RIPK4, a novel target in cancer therapy.
- Abstract
- The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integration of various stress signals. In response to several extracellular and/or intracellular stimuli, RIP kinases engage signaling cascades leading to the activation of NF-& kappa;B and mitogen-activated protein kinases, cell death, inflammation, differentiation and Wnt signaling and can have kinase-dependent and kinase-independent functions. Although it was previously suggested that seven RIPKs are part of the RIPK family, phylogenetic analysis indicates that there are only five genuine RIPKs. RIPK1 and RIPK3 are mainly involved in controlling and executing necroptosis in keratinocytes, while RIPK4 controls proliferation and differentiation of keratinocytes and thereby can act as a tumor suppressor in skin. Therefore, in this review we summarize and discuss the functions of RIPKs in skin homeostasis as well as the signaling pathways involved.
- Keywords
- Receptor interacting kinases, Skin, Keratinocyte, Differentiation, Signalling, NF-KAPPA-B, C-ASSOCIATED KINASE, REGULATORY FACTOR 6, PROTEIN-KINASE, CELL-DEATH, BARTSOCAS-PAPAS, MICE LACKING, IKK-ALPHA, KERATINOCYTE PROLIFERATION, EPIDERMAL DIFFERENTIATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HCYW4CPCQQFN1JY5KRFN0GWP
- MLA
- Urwyler, Corinne, et al. “Functions of the RIP Kinase Family Members in the Skin.” CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 80, no. 10, 2023, doi:10.1007/s00018-023-04917-2.
- APA
- Urwyler, C., Tanghe, G., Devos, M., Hulpiau, P., Saeys, Y., & Declercq, W. (2023). Functions of the RIP kinase family members in the skin. CELLULAR AND MOLECULAR LIFE SCIENCES, 80(10). https://doi.org/10.1007/s00018-023-04917-2
- Chicago author-date
- Urwyler, Corinne, Giel Tanghe, Michael Devos, Paco Hulpiau, Yvan Saeys, and Wim Declercq. 2023. “Functions of the RIP Kinase Family Members in the Skin.” CELLULAR AND MOLECULAR LIFE SCIENCES 80 (10). https://doi.org/10.1007/s00018-023-04917-2.
- Chicago author-date (all authors)
- Urwyler, Corinne, Giel Tanghe, Michael Devos, Paco Hulpiau, Yvan Saeys, and Wim Declercq. 2023. “Functions of the RIP Kinase Family Members in the Skin.” CELLULAR AND MOLECULAR LIFE SCIENCES 80 (10). doi:10.1007/s00018-023-04917-2.
- Vancouver
- 1.Urwyler C, Tanghe G, Devos M, Hulpiau P, Saeys Y, Declercq W. Functions of the RIP kinase family members in the skin. CELLULAR AND MOLECULAR LIFE SCIENCES. 2023;80(10).
- IEEE
- [1]C. Urwyler, G. Tanghe, M. Devos, P. Hulpiau, Y. Saeys, and W. Declercq, “Functions of the RIP kinase family members in the skin,” CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 80, no. 10, 2023.
@article{01HCYW4CPCQQFN1JY5KRFN0GWP,
abstract = {{The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integration of various stress signals. In response to several extracellular and/or intracellular stimuli, RIP kinases engage signaling cascades leading to the activation of NF-& kappa;B and mitogen-activated protein kinases, cell death, inflammation, differentiation and Wnt signaling and can have kinase-dependent and kinase-independent functions. Although it was previously suggested that seven RIPKs are part of the RIPK family, phylogenetic analysis indicates that there are only five genuine RIPKs. RIPK1 and RIPK3 are mainly involved in controlling and executing necroptosis in keratinocytes, while RIPK4 controls proliferation and differentiation of keratinocytes and thereby can act as a tumor suppressor in skin. Therefore, in this review we summarize and discuss the functions of RIPKs in skin homeostasis as well as the signaling pathways involved.}},
articleno = {{285}},
author = {{Urwyler, Corinne and Tanghe, Giel and Devos, Michael and Hulpiau, Paco and Saeys, Yvan and Declercq, Wim}},
issn = {{1420-682X}},
journal = {{CELLULAR AND MOLECULAR LIFE SCIENCES}},
keywords = {{Receptor interacting kinases,Skin,Keratinocyte,Differentiation,Signalling,NF-KAPPA-B,C-ASSOCIATED KINASE,REGULATORY FACTOR 6,PROTEIN-KINASE,CELL-DEATH,BARTSOCAS-PAPAS,MICE LACKING,IKK-ALPHA,KERATINOCYTE PROLIFERATION,EPIDERMAL DIFFERENTIATION}},
language = {{eng}},
number = {{10}},
pages = {{21}},
title = {{Functions of the RIP kinase family members in the skin}},
url = {{http://doi.org/10.1007/s00018-023-04917-2}},
volume = {{80}},
year = {{2023}},
}
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