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Early recognition and access to terminal complement blockers in patients with atypical HUS significantly improves their outcome : a case report

Amelien Vanacker (UGent) , Nathalie Segers (UGent) , An Bael, Muriel Koninckx, Ann Raes (UGent) , Johan Vande Walle (UGent) , Jo Dehoorne (UGent) , Agnieszka Prytula-Ebels (UGent) , Lien Dossche (UGent) , Thomas Renson (UGent) , et al.
(2023) BELGIAN JOURNAL OF PAEDIATRICS. 25(2). p.129-132
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Abstract
A 7-year-old boy presented with fever, pruritus and petechiae. Laboratory analysis revealed haemolytic anaemia with presence of schistocytes, thrombocytopenia and acute kidney injury, diagnostic for a thrombotic microangiopathy (TMA). Given the severe clinical presentation, the lack of evidence for verotoxin positive TMA and a normal ADAMTS13, treatment with eculizumab was started. This resulted in a complete resolution of the TMA course with recovery of the kidney injury. Workup revealed high titre of anti-factor H antibodies, diagnostic for an atypical haemolytic uremic syndrome (aHUS). Early recognition and treatment of TMA is essential to optimize the outcome of these patients.
Keywords
atypical HUS, TMA

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MLA
Vanacker, Amelien, et al. “Early Recognition and Access to Terminal Complement Blockers  in Patients with Atypical HUS Significantly Improves Their  Outcome : A Case Report.” BELGIAN JOURNAL OF PAEDIATRICS, vol. 25, no. 2, 2023, pp. 129–32.
APA
Vanacker, A., Segers, N., Bael, A., Koninckx, M., Raes, A., Vande Walle, J., … Snauwaert, E. (2023). Early recognition and access to terminal complement blockers  in patients with atypical HUS significantly improves their  outcome : a case report. BELGIAN JOURNAL OF PAEDIATRICS, 25(2), 129–132.
Chicago author-date
Vanacker, Amelien, Nathalie Segers, An Bael, Muriel Koninckx, Ann Raes, Johan Vande Walle, Jo Dehoorne, et al. 2023. “Early Recognition and Access to Terminal Complement Blockers  in Patients with Atypical HUS Significantly Improves Their  Outcome : A Case Report.” BELGIAN JOURNAL OF PAEDIATRICS 25 (2): 129–32.
Chicago author-date (all authors)
Vanacker, Amelien, Nathalie Segers, An Bael, Muriel Koninckx, Ann Raes, Johan Vande Walle, Jo Dehoorne, Agnieszka Prytula-Ebels, Lien Dossche, Thomas Renson, and Evelien Snauwaert. 2023. “Early Recognition and Access to Terminal Complement Blockers  in Patients with Atypical HUS Significantly Improves Their  Outcome : A Case Report.” BELGIAN JOURNAL OF PAEDIATRICS 25 (2): 129–132.
Vancouver
1.
Vanacker A, Segers N, Bael A, Koninckx M, Raes A, Vande Walle J, et al. Early recognition and access to terminal complement blockers  in patients with atypical HUS significantly improves their  outcome : a case report. BELGIAN JOURNAL OF PAEDIATRICS. 2023;25(2):129–32.
IEEE
[1]
A. Vanacker et al., “Early recognition and access to terminal complement blockers  in patients with atypical HUS significantly improves their  outcome : a case report,” BELGIAN JOURNAL OF PAEDIATRICS, vol. 25, no. 2, pp. 129–132, 2023.
@article{01HCNAFS0WWMDB5TCC6JDTA182,
  abstract     = {{A 7-year-old boy presented with fever, pruritus and petechiae. Laboratory analysis revealed haemolytic anaemia with presence of schistocytes, thrombocytopenia and acute kidney injury, diagnostic for a thrombotic microangiopathy (TMA). Given the severe clinical presentation, the lack of evidence for verotoxin positive TMA and a normal ADAMTS13, treatment with eculizumab was started. This resulted in a complete resolution of the TMA course with recovery of the kidney injury. Workup revealed high titre of anti-factor H antibodies, diagnostic for an atypical haemolytic uremic syndrome (aHUS). Early recognition and treatment of TMA is essential to optimize the outcome of these patients.}},
  author       = {{Vanacker, Amelien and Segers, Nathalie and Bael, An and Koninckx, Muriel and Raes, Ann and Vande Walle, Johan and Dehoorne, Jo and Prytula-Ebels, Agnieszka and Dossche, Lien and Renson, Thomas and Snauwaert, Evelien}},
  issn         = {{2466-8907}},
  journal      = {{BELGIAN JOURNAL OF PAEDIATRICS}},
  keywords     = {{atypical HUS,TMA}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{129--132}},
  title        = {{Early recognition and access to terminal complement blockers  in patients with atypical HUS significantly improves their  outcome : a case report}},
  url          = {{https://belgjpaediatrics.be/index.php/bjp/article/view/62}},
  volume       = {{25}},
  year         = {{2023}},
}