@article{01HA7EYZ8XHWW81WDEKMQVNAN9,
  abstract     = {{Aims To develop and validate a recalibrated prediction model (SCORE2-Diabetes) to estimate the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. Methods and results SCORE2-Diabetes was developed by extending SCORE2 algorithms using individual-participant data from four large-scale datasets comprising 229 460 participants (43 706 CVD events) with type 2 diabetes and without previous CVD. Sex-specific competing risk-adjusted models were used including conventional risk factors (i.e. age, smoking, systolic blood pressure, total, and HDL-cholesterol), as well as diabetes-related variables (i.e. age at diabetes diagnosis, glycated haemoglobin [HbA1c] and creatinine-based estimated glomerular filtration rate [eGFR]). Models were recalibrated to CVD incidence in four European risk regions. External validation included 217 036 further individuals (38 602 CVD events), and showed good discrimination, and improvement over SCORE2 (C-index change from 0.009 to 0.031). Regional calibration was satisfactory. SCORE2-Diabetes risk predictions varied several-fold, depending on individuals' levels of diabetes-related factors. For example, in the moderate-risk region, the estimated 10-year CVD risk was 11% for a 60-year-old man, non-smoker, with type 2 diabetes, average conventional risk factors, HbA1c of 50 mmol/mol, eGFR of 90 mL/min/1.73 m(2), and age at diabetes diagnosis of 60 years. By contrast, the estimated risk was 17% in a similar man, with HbA1c of 70 mmol/mol, eGFR of 60 mL/min/1.73 m(2), and age at diabetes diagnosis of 50 years. For a woman with the same characteristics, the risk was 8% and 13%, respectively. Conclusion SCORE2-Diabetes, a new algorithm developed, calibrated, and validated to predict 10-year risk of CVD in individuals with type 2 diabetes, enhances identification of individuals at higher risk of developing CVD across Europe.}},
  author       = {{SCORE2-Diabetes Working Group and the ESC Cardiovascular Risk Collaboration, [missing] and Pennells, Lisa and Kaptoge, Stephen and Østergaard, Helena Bleken and Read, Stephanie H and Carinci, Fabrizio and Franch-Nadal, Josep and Petitjean, Carmen and Taylor, Owen and Hageman, Steven H J and Xu, Zhe and Shi, Fanchao and Spackman, Sarah and Gualdi, Stefano and Holman, Naomi and Da Providencia E Costa, Rui Bebiano and Bonnet, Fabrice and Brenner, Hermann and Gillum, Richard F and Kiechl, Stefan and Lawlor, Deborah A and Potier, Louis and Schöttker, Ben and Sofat, Reecha and Völzke, Henry and Willeit, Johann and Baltane, Zane and Fava, Stephen and Janos, Sandor and Lavens, Astrid and Pildava, Santa and Poljicanin, Tamara and Pristas, Ivan and Rossing, Peter and Sascha, Reiff and Scheidt-Nave, Christa and Stotl, Iztok and Tibor, Gail and Urbančič-Rovan, Vilma and Vanherwegen, An-Sofie and Vistisen, Dorte and Du, Yong and Walker, Matthew R and Willeit, Peter and Ference, Brian and De Bacquer, Dirk and Halle, Martin and Huculeci, Radu and McEvoy, John William and Timmis, Adam and Vardas, Panagiotis and Dorresteijn, Jannick A N and Graham, Ian and Wood, Angela and Eliasson, Björn and Herrington, William and Danesh, John and Mauricio, Dídac and Benedetti, Massimo Massi and Sattar, Naveed and Visseren, Frank L J and Wild, Sarah and Di Angelantonio, Emanuele and Balkau, Beverley and Bonnet, Fabrice and Fumeron, Frederic and Stocker, Hannah and Holleczek, Bernd and Schipf, Sabine and Schmidt, Carsten Oliver and Dörr, Marcus and Tilg, Herbert and Leitner, Christoph and Notdurfter, Marlene and Taylor, Julie and Dale, Caroline and Prieto-Merino, David and Gillum, Richard F and Lavens, Astrid and Vanherwegen, An-Sofie and Poljicanin, Tamara and Pristas, Ivan and Buble, Tamara and Ivanko, Pero and Rossing, Peter and Carstensen, Bendix and Heidemann, Christin and Du, Yong and Scheidt-Nave, Christa and Gall, Tibor and Sandor, Janos and Baltane, Zane and Pildava, Santa and Lepiksone, Jana and Magri, Caroline J and Azzopardi, Joseph and Stotl, Iztok and Real, Jordi and Vlacho, Bogdan and Mata-Cases, Manel}},
  issn         = {{0195-668X}},
  journal      = {{EUROPEAN HEART JOURNAL}},
  keywords     = {{Cardiology and Cardiovascular Medicine,Cardiovascular diseases,Diabetes,Prediction model}},
  language     = {{eng}},
  number       = {{28}},
  pages        = {{2544--2556}},
  publisher    = {{Oxford University Press (OUP)}},
  title        = {{SCORE2-diabetes : 10-year cardiovascular risk estimation in type 2 diabetes in Europe}},
  url          = {{http://doi.org/10.1093/eurheartj/ehad260}},
  volume       = {{44}},
  year         = {{2023}},
}

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