Modelling of blood loss influence on propofol concentrations and anesthetic states in critical responses
- Author
- Mihaela Ghita (UGent) , Dana Copot (UGent) , Isabela Roxana Birs (UGent) , Cristina Muresan, Martine Neckebroek (UGent) and Clara-Mihaela Ionescu (UGent)
- Organization
- Project
-
- Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery (AMICAS)
- Modelling and validation of analgesia prediction for computer-guided TIVA systems
- Adaptive robust control of general anesthesia with event-based surgery mapping and variable patient models
- A complete drug regulatory guide for surgical interventions under general anesthesia
- Development of an integrated end-to-end simulation platform for continuous manufacturing of oral tablets
- Abstract
- This work studies the classical pharmacokinetic-pharmacodynamic (PK-PD) model of Propofol for total intravenous anesthesia in response to intraoperative blood loss. Anesthetic and hemodynamic stability are impaired in the setting of trauma surgeries or major procedures with high hemorrhage risk. Blood loss has immediate effects on the cardiovascular system, but also affects the plasma concentration of the perioperatively infused drugs. During perioperative transition periods, when fast blood losses occur, the PK models on which the target-controlled infusion (TCI) is based should be updated. Then, the population-based parameters move towards an individualized strategy that accounts also for the actual blood volume in the patient. This paper evaluates the influence of changing blood volume on the PK model of Propofol, hence on the anesthesia state of the patient. The simulations also account for the hemodynamic responses due to the conflicting interactions of both hemorrhage and anesthetic drug infusion. This model has great potential for inclusion in multiple-closed loop control strategies of anesthesia-hemodynamic states, as it is simple and adapted from well-known PK models, for which control strategies are already mature.
- Keywords
- CARDIAC-OUTPUT, HEMORRHAGE, LOOP, PRESSURE, HYPNOSIS, DYNAMICS, DESIGN
Downloads
-
(...).pdf
- full text (Published version)
- |
- UGent only
- |
- |
- 3.02 MB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HA6ZEN189WZRD6WJKDW55AC4
- MLA
- Ghita, Mihaela, et al. “Modelling of Blood Loss Influence on Propofol Concentrations and Anesthetic States in Critical Responses.” 2023 AMERICAN CONTROL CONFERENCE, ACC, IEEE, 2023, pp. 2216–21, doi:10.23919/ACC55779.2023.10156356.
- APA
- Ghita, M., Copot, D., Birs, I. R., Muresan, C., Neckebroek, M., & Ionescu, C.-M. (2023). Modelling of blood loss influence on propofol concentrations and anesthetic states in critical responses. 2023 AMERICAN CONTROL CONFERENCE, ACC, 2216–2221. https://doi.org/10.23919/ACC55779.2023.10156356
- Chicago author-date
- Ghita, Mihaela, Dana Copot, Isabela Roxana Birs, Cristina Muresan, Martine Neckebroek, and Clara-Mihaela Ionescu. 2023. “Modelling of Blood Loss Influence on Propofol Concentrations and Anesthetic States in Critical Responses.” In 2023 AMERICAN CONTROL CONFERENCE, ACC, 2216–21. IEEE. https://doi.org/10.23919/ACC55779.2023.10156356.
- Chicago author-date (all authors)
- Ghita, Mihaela, Dana Copot, Isabela Roxana Birs, Cristina Muresan, Martine Neckebroek, and Clara-Mihaela Ionescu. 2023. “Modelling of Blood Loss Influence on Propofol Concentrations and Anesthetic States in Critical Responses.” In 2023 AMERICAN CONTROL CONFERENCE, ACC, 2216–2221. IEEE. doi:10.23919/ACC55779.2023.10156356.
- Vancouver
- 1.Ghita M, Copot D, Birs IR, Muresan C, Neckebroek M, Ionescu C-M. Modelling of blood loss influence on propofol concentrations and anesthetic states in critical responses. In: 2023 AMERICAN CONTROL CONFERENCE, ACC. IEEE; 2023. p. 2216–21.
- IEEE
- [1]M. Ghita, D. Copot, I. R. Birs, C. Muresan, M. Neckebroek, and C.-M. Ionescu, “Modelling of blood loss influence on propofol concentrations and anesthetic states in critical responses,” in 2023 AMERICAN CONTROL CONFERENCE, ACC, San Diego, CA, 2023, pp. 2216–2221.
@inproceedings{01HA6ZEN189WZRD6WJKDW55AC4,
abstract = {{This work studies the classical pharmacokinetic-pharmacodynamic (PK-PD) model of Propofol for total intravenous anesthesia in response to intraoperative blood loss. Anesthetic and hemodynamic stability are impaired in the setting of trauma surgeries or major procedures with high hemorrhage risk. Blood loss has immediate effects on the cardiovascular system, but also affects the plasma concentration of the perioperatively infused drugs. During perioperative transition periods, when fast blood losses occur, the PK models on which the target-controlled infusion (TCI) is based should be updated. Then, the population-based parameters move towards an individualized strategy that accounts also for the actual blood volume in the patient. This paper evaluates the influence of changing blood volume on the PK model of Propofol, hence on the anesthesia state of the patient. The simulations also account for the hemodynamic responses due to the conflicting interactions of both hemorrhage and anesthetic drug infusion. This model has great potential for inclusion in multiple-closed loop control strategies of anesthesia-hemodynamic states, as it is simple and adapted from well-known PK models, for which control strategies are already mature.}},
author = {{Ghita, Mihaela and Copot, Dana and Birs, Isabela Roxana and Muresan, Cristina and Neckebroek, Martine and Ionescu, Clara-Mihaela}},
booktitle = {{2023 AMERICAN CONTROL CONFERENCE, ACC}},
isbn = {{9798350328066}},
issn = {{0743-1619}},
keywords = {{CARDIAC-OUTPUT,HEMORRHAGE,LOOP,PRESSURE,HYPNOSIS,DYNAMICS,DESIGN}},
language = {{eng}},
location = {{San Diego, CA}},
pages = {{2216--2221}},
publisher = {{IEEE}},
title = {{Modelling of blood loss influence on propofol concentrations and anesthetic states in critical responses}},
url = {{http://doi.org/10.23919/ACC55779.2023.10156356}},
year = {{2023}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: