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Pre- to postoperative longitudinal follow-up of phoneme perception in glioma patients : evidence from the Mismatch Negativity and P300

Yana Criel (UGent) , Edward Baert (UGent) , Jean-Pierre Kalala Okito (UGent) , Giorgio Hallaert (UGent) , Dirk Van Roost (UGent) , Luc De Baerdemaeker (UGent) , Wouter Degrève (UGent) , Marijke Miatton (UGent) , Patrick Santens (UGent) , Pieter van Mierlo (UGent) , et al.
(2024) APHASIOLOGY. p.1-35
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Abstract
Background and AimsGlioma growth in eloquent language areas induces adaptive activation changes in the language network. The present study aimed to (1) investigate the pre- to postoperative evolution of neural phoneme perception processes in glioma patients and (2) assess if event-related potentials (ERPs) reflecting phoneme perception can provide added value to the diagnostic approach in individuals undergoing awake surgery.Methods and ProceduresIn five persons undergoing an awake craniotomy for the resection of a glioma, pre- and postoperative behavioural language assessment (Aachen Aphasia Test, Comprehensive Aphasia Test and Boston Naming Test) and electrophysiological investigation of phoneme perception was performed. For the latter, ERPs were obtained through the administration of an inattentive (Mismatch Negativity; MMN) and attentive (P300) oddball paradigm containing a phonemic articulation place contrast during EEG recording.Outcomes and ResultsAberrant phoneme categorization processing was evidenced in all five participants preoperatively based on the MMN and P300 amplitude and latency. Moreover, mild behavioural impairments were found in four participants at this time. Postoperatively, three out of five participants reached behavioural ceiling effects, while four individuals displayed normalization of electrophysiological measures.ConclusionsWhile neural processing of phoneme contrasts was preoperatively affected by glioma-induced disturbances, a high potential for postsurgical plasticity was shown. As four participants presented with a high grade glioma, tumour grade might partially account for this pattern. Addition of electrophysiological tests to the language assessment could provide benefits in both the pre- and postoperative clinical diagnostic approach in glioma patients. These preliminary results need validation in a larger sample.
Keywords
Neurology (clinical), Neurology, Linguistics and Language, Language and Linguistics, P300, Mismatch Negativity (MMN), Event-related potential (ERP), Glioma

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MLA
Criel, Yana, et al. “Pre- to Postoperative Longitudinal Follow-up of Phoneme Perception in Glioma Patients : Evidence from the Mismatch Negativity and P300.” APHASIOLOGY, Informa UK Limited, 2024, pp. 1–35, doi:10.1080/02687038.2023.2251176.
APA
Criel, Y., Baert, E., Kalala Okito, J.-P., Hallaert, G., Van Roost, D., De Baerdemaeker, L., … De Letter, M. (2024). Pre- to postoperative longitudinal follow-up of phoneme perception in glioma patients : evidence from the Mismatch Negativity and P300. APHASIOLOGY, 1–35. https://doi.org/10.1080/02687038.2023.2251176
Chicago author-date
Criel, Yana, Edward Baert, Jean-Pierre Kalala Okito, Giorgio Hallaert, Dirk Van Roost, Luc De Baerdemaeker, Wouter Degrève, et al. 2024. “Pre- to Postoperative Longitudinal Follow-up of Phoneme Perception in Glioma Patients : Evidence from the Mismatch Negativity and P300.” APHASIOLOGY, 1–35. https://doi.org/10.1080/02687038.2023.2251176.
Chicago author-date (all authors)
Criel, Yana, Edward Baert, Jean-Pierre Kalala Okito, Giorgio Hallaert, Dirk Van Roost, Luc De Baerdemaeker, Wouter Degrève, Marijke Miatton, Patrick Santens, Pieter van Mierlo, and Miet De Letter. 2024. “Pre- to Postoperative Longitudinal Follow-up of Phoneme Perception in Glioma Patients : Evidence from the Mismatch Negativity and P300.” APHASIOLOGY: 1–35. doi:10.1080/02687038.2023.2251176.
Vancouver
1.
Criel Y, Baert E, Kalala Okito J-P, Hallaert G, Van Roost D, De Baerdemaeker L, et al. Pre- to postoperative longitudinal follow-up of phoneme perception in glioma patients : evidence from the Mismatch Negativity and P300. APHASIOLOGY. 2024;1–35.
IEEE
[1]
Y. Criel et al., “Pre- to postoperative longitudinal follow-up of phoneme perception in glioma patients : evidence from the Mismatch Negativity and P300,” APHASIOLOGY, pp. 1–35, 2024.
@article{01HA6HDG9Q4EKC1AZCXTCC2GZX,
  abstract     = {{Background and AimsGlioma growth in eloquent language areas induces adaptive activation changes in the language network. The present study aimed to (1) investigate the pre- to postoperative evolution of neural phoneme perception processes in glioma patients and (2) assess if event-related potentials (ERPs) reflecting phoneme perception can provide added value to the diagnostic approach in individuals undergoing awake surgery.Methods and ProceduresIn five persons undergoing an awake craniotomy for the resection of a glioma, pre- and postoperative behavioural language assessment (Aachen Aphasia Test, Comprehensive Aphasia Test and Boston Naming Test) and electrophysiological investigation of phoneme perception was performed. For the latter, ERPs were obtained through the administration of an inattentive (Mismatch Negativity; MMN) and attentive (P300) oddball paradigm containing a phonemic articulation place contrast during EEG recording.Outcomes and ResultsAberrant phoneme categorization processing was evidenced in all five participants preoperatively based on the MMN and P300 amplitude and latency. Moreover, mild behavioural impairments were found in four participants at this time. Postoperatively, three out of five participants reached behavioural ceiling effects, while four individuals displayed normalization of electrophysiological measures.ConclusionsWhile neural processing of phoneme contrasts was preoperatively affected by glioma-induced disturbances, a high potential for postsurgical plasticity was shown. As four participants presented with a high grade glioma, tumour grade might partially account for this pattern. Addition of electrophysiological tests to the language assessment could provide benefits in both the pre- and postoperative clinical diagnostic approach in glioma patients. These preliminary results need validation in a larger sample.}},
  author       = {{Criel, Yana and Baert, Edward and Kalala Okito, Jean-Pierre and Hallaert, Giorgio and Van Roost, Dirk and De Baerdemaeker, Luc and Degrève, Wouter and Miatton, Marijke and Santens, Patrick and van Mierlo, Pieter and De Letter, Miet}},
  issn         = {{0268-7038}},
  journal      = {{APHASIOLOGY}},
  keywords     = {{Neurology (clinical),Neurology,Linguistics and Language,Language and Linguistics,P300,Mismatch Negativity (MMN),Event-related potential (ERP),Glioma}},
  language     = {{eng}},
  pages        = {{1--35}},
  publisher    = {{Informa UK Limited}},
  title        = {{Pre- to postoperative longitudinal follow-up of phoneme perception in glioma patients : evidence from the Mismatch Negativity and P300}},
  url          = {{http://doi.org/10.1080/02687038.2023.2251176}},
  year         = {{2024}},
}

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