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Effects of hyperthermia and hyperthermic intraperitoneal chemoperfusion on the peritoneal and tumor immune contexture

Daryl K. A. Chia, Jesse Demuytere (UGent) , Sam Ernst (UGent) , Hooman Salavati (UGent) and Wim Ceelen (UGent)
(2023) CANCERS. 15(17).
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Abstract
Simple Summary Cancer that spreads to the lining of the abdomen, the peritoneum, is currently treated with heated chemotherapy and surgery. However, the effects of the high temperature on the cancer cells and the immune cells are still unclear. In this review, we summarize the available data to show that high temperatures may have both positive and negative effects, and that further study is necessary to distinguish these effects.Abstract Hyperthermia combined with intraperitoneal (IP) drug delivery is increasingly used in the treatment of peritoneal metastases (PM). Hyperthermia enhances tumor perfusion and increases drug penetration after IP delivery. The peritoneum is increasingly recognized as an immune-privileged organ with its own distinct immune microenvironment. Here, we review the immune landscape of the healthy peritoneal cavity and immune contexture of peritoneal metastases. Next, we review the potential benefits and unwanted tumor-promoting effects of hyperthermia and the associated heat shock response on the tumor immune microenvironment. We highlight the potential modulating effect of hyperthermia on the biomechanical properties of tumor tissue and the consequences for immune cell infiltration. Data from translational and clinical studies are reviewed. We conclude that (mild) hyperthermia and HIPEC have the potential to enhance antitumor immunity, but detailed further studies are required to distinguish beneficial from tumor-promoting effects.
Keywords
Cancer Research, Oncology, intraperitoneal chemotherapy, peritoneal metastases, peritoneal carcinomatosis, hyperthermia

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MLA
Chia, Daryl K. A., et al. “Effects of Hyperthermia and Hyperthermic Intraperitoneal Chemoperfusion on the Peritoneal and Tumor Immune Contexture.” CANCERS, vol. 15, no. 17, MDPI AG, 2023, doi:10.3390/cancers15174314.
APA
Chia, D. K. A., Demuytere, J., Ernst, S., Salavati, H., & Ceelen, W. (2023). Effects of hyperthermia and hyperthermic intraperitoneal chemoperfusion on the peritoneal and tumor immune contexture. CANCERS, 15(17). https://doi.org/10.3390/cancers15174314
Chicago author-date
Chia, Daryl K. A., Jesse Demuytere, Sam Ernst, Hooman Salavati, and Wim Ceelen. 2023. “Effects of Hyperthermia and Hyperthermic Intraperitoneal Chemoperfusion on the Peritoneal and Tumor Immune Contexture.” CANCERS 15 (17). https://doi.org/10.3390/cancers15174314.
Chicago author-date (all authors)
Chia, Daryl K. A., Jesse Demuytere, Sam Ernst, Hooman Salavati, and Wim Ceelen. 2023. “Effects of Hyperthermia and Hyperthermic Intraperitoneal Chemoperfusion on the Peritoneal and Tumor Immune Contexture.” CANCERS 15 (17). doi:10.3390/cancers15174314.
Vancouver
1.
Chia DKA, Demuytere J, Ernst S, Salavati H, Ceelen W. Effects of hyperthermia and hyperthermic intraperitoneal chemoperfusion on the peritoneal and tumor immune contexture. CANCERS. 2023;15(17).
IEEE
[1]
D. K. A. Chia, J. Demuytere, S. Ernst, H. Salavati, and W. Ceelen, “Effects of hyperthermia and hyperthermic intraperitoneal chemoperfusion on the peritoneal and tumor immune contexture,” CANCERS, vol. 15, no. 17, 2023.
@article{01H9FT6P9G0KJEAK1V0V3BPC1V,
  abstract     = {{Simple Summary Cancer that spreads to the lining of the abdomen, the peritoneum, is currently treated with heated chemotherapy and surgery. However, the effects of the high temperature on the cancer cells and the immune cells are still unclear. In this review, we summarize the available data to show that high temperatures may have both positive and negative effects, and that further study is necessary to distinguish these effects.Abstract Hyperthermia combined with intraperitoneal (IP) drug delivery is increasingly used in the treatment of peritoneal metastases (PM). Hyperthermia enhances tumor perfusion and increases drug penetration after IP delivery. The peritoneum is increasingly recognized as an immune-privileged organ with its own distinct immune microenvironment. Here, we review the immune landscape of the healthy peritoneal cavity and immune contexture of peritoneal metastases. Next, we review the potential benefits and unwanted tumor-promoting effects of hyperthermia and the associated heat shock response on the tumor immune microenvironment. We highlight the potential modulating effect of hyperthermia on the biomechanical properties of tumor tissue and the consequences for immune cell infiltration. Data from translational and clinical studies are reviewed. We conclude that (mild) hyperthermia and HIPEC have the potential to enhance antitumor immunity, but detailed further studies are required to distinguish beneficial from tumor-promoting effects.}},
  articleno    = {{4314}},
  author       = {{Chia, Daryl K. A. and Demuytere, Jesse and Ernst, Sam and Salavati, Hooman and Ceelen, Wim}},
  issn         = {{2072-6694}},
  journal      = {{CANCERS}},
  keywords     = {{Cancer Research,Oncology,intraperitoneal chemotherapy,peritoneal metastases,peritoneal carcinomatosis,hyperthermia}},
  language     = {{eng}},
  number       = {{17}},
  pages        = {{15}},
  publisher    = {{MDPI AG}},
  title        = {{Effects of hyperthermia and hyperthermic intraperitoneal chemoperfusion on the peritoneal and tumor immune contexture}},
  url          = {{http://doi.org/10.3390/cancers15174314}},
  volume       = {{15}},
  year         = {{2023}},
}
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