- Author
- Jaianth Vijayakumar (UGent) , Niloofar Moazami Goudarzi (UGent) , Guy Eeckhaut, Koen Schrijnemakers, Veerle Cnudde (UGent) and Matthieu Boone (UGent)
- Organization
- Project
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- Advanced Computed X-ray Tomography (CT) methods with combined chemical and solid state structural information for the detailed analysis of pharmaceutical solid dose drug products
- In-situ characterization of drug release and dissolution processes in sustained-release solid dosage forms
- Cofinancing core facility - Centre for X-ray Tomography – UGCT
- Abstract
- Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry.
- Keywords
- X-ray tomography, pharmaceutical tablets, image processing, X-ray tomography modalities, NEAR-INFRARED SPECTROSCOPY, DIFFRACTION CONTRAST TOMOGRAPHY, MICRO-COMPUTED-TOMOGRAPHY, BIOPHARMACEUTIC-DRUG-CLASSIFICATION, ASSESSING HOMOGENEITY DISTRIBUTION, SOLID-STATE CHARACTERIZATION, CONTROLLED-RELEASE KINETICS, PHASE-CONTRAST, MECHANICAL-PROPERTIES, RAMAN-SPECTROSCOPY
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01H81M92R77VQH65PCD30C37VB
- MLA
- Vijayakumar, Jaianth, et al. “Characterization of Pharmaceutical Tablets by X-Ray Tomography.” PHARMACEUTICALS, vol. 16, no. 5, 2023, doi:10.3390/ph16050733.
- APA
- Vijayakumar, J., Moazami Goudarzi, N., Eeckhaut, G., Schrijnemakers, K., Cnudde, V., & Boone, M. (2023). Characterization of pharmaceutical tablets by X-ray tomography. PHARMACEUTICALS, 16(5). https://doi.org/10.3390/ph16050733
- Chicago author-date
- Vijayakumar, Jaianth, Niloofar Moazami Goudarzi, Guy Eeckhaut, Koen Schrijnemakers, Veerle Cnudde, and Matthieu Boone. 2023. “Characterization of Pharmaceutical Tablets by X-Ray Tomography.” PHARMACEUTICALS 16 (5). https://doi.org/10.3390/ph16050733.
- Chicago author-date (all authors)
- Vijayakumar, Jaianth, Niloofar Moazami Goudarzi, Guy Eeckhaut, Koen Schrijnemakers, Veerle Cnudde, and Matthieu Boone. 2023. “Characterization of Pharmaceutical Tablets by X-Ray Tomography.” PHARMACEUTICALS 16 (5). doi:10.3390/ph16050733.
- Vancouver
- 1.Vijayakumar J, Moazami Goudarzi N, Eeckhaut G, Schrijnemakers K, Cnudde V, Boone M. Characterization of pharmaceutical tablets by X-ray tomography. PHARMACEUTICALS. 2023;16(5).
- IEEE
- [1]J. Vijayakumar, N. Moazami Goudarzi, G. Eeckhaut, K. Schrijnemakers, V. Cnudde, and M. Boone, “Characterization of pharmaceutical tablets by X-ray tomography,” PHARMACEUTICALS, vol. 16, no. 5, 2023.
@article{01H81M92R77VQH65PCD30C37VB,
abstract = {{Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry.}},
articleno = {{733}},
author = {{Vijayakumar, Jaianth and Moazami Goudarzi, Niloofar and Eeckhaut, Guy and Schrijnemakers, Koen and Cnudde, Veerle and Boone, Matthieu}},
issn = {{1424-8247}},
journal = {{PHARMACEUTICALS}},
keywords = {{X-ray tomography,pharmaceutical tablets,image processing,X-ray tomography modalities,NEAR-INFRARED SPECTROSCOPY,DIFFRACTION CONTRAST TOMOGRAPHY,MICRO-COMPUTED-TOMOGRAPHY,BIOPHARMACEUTIC-DRUG-CLASSIFICATION,ASSESSING HOMOGENEITY DISTRIBUTION,SOLID-STATE CHARACTERIZATION,CONTROLLED-RELEASE KINETICS,PHASE-CONTRAST,MECHANICAL-PROPERTIES,RAMAN-SPECTROSCOPY}},
language = {{eng}},
number = {{5}},
pages = {{41}},
title = {{Characterization of pharmaceutical tablets by X-ray tomography}},
url = {{http://doi.org/10.3390/ph16050733}},
volume = {{16}},
year = {{2023}},
}
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