Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
2 files | 9.11 MB
Add to list
  1. Search results
  2. The epithelial-mesenchymal plasticity...

The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation

Jef Haerinck (UGent) , Steven Goossens (UGent) and Geert Berx (UGent)
(2023) NATURE REVIEWS GENETICS. 24(9). p.590-609
Author
Organization
Project
Abstract
Recent systems biology and single-cell approaches have revealed the impact of the microenvironment, lineage specification and cell identity, and the genome on epithelial-mesenchymal plasticity (EMP). In addition, cell memory (hysteresis) and cellular noise can drive stochastic transitions between cell states. The authors review these forces and the regulatory mechanisms that stabilize EMP states or facilitate epithelial-mesenchymal transitions (EMTs). Epithelial-mesenchymal plasticity (EMP) enables cells to interconvert between several states across the epithelial-mesenchymal landscape, thereby acquiring hybrid epithelial/mesenchymal phenotypic features. This plasticity is crucial for embryonic development and wound healing, but also underlies the acquisition of several malignant traits during cancer progression. Recent research using systems biology and single-cell profiling methods has provided novel insights into the main forces that shape EMP, which include the microenvironment, lineage specification and cell identity, and the genome. Additionally, key roles have emerged for hysteresis (cell memory) and cellular noise, which can drive stochastic transitions between cell states. Here, we review these forces and the distinct but interwoven layers of regulatory control that stabilize EMP states or facilitate epithelial-mesenchymal transitions (EMTs) and discuss the therapeutic potential of manipulating the EMP landscape.
Keywords
DOUBLE-NEGATIVE FEEDBACK, DIAMOND-BLACKFAN ANEMIA, BREAST-CANCER CELLS, TRANSCRIPTION FACTOR SNAIL, CADHERIN GENE-EXPRESSION, CIRCULATING TUMOR-CELLS, FATTY-ACID SYNTHASE, GROWTH-FACTOR, MEMBRANE-FLUIDITY, PROSTATE-CANCER

Downloads

  • Download
    (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 5.52 MB
  • Download
    AAM Haerinck.pdf
    • full text (Accepted manuscript)
    • |
    • open access
    • |
    • PDF
    • |
    • 3.59 MB

Citation

Please use this url to cite or link to this publication:

MLA
Haerinck, Jef, et al. “The Epithelial-Mesenchymal Plasticity Landscape: Principles of Design and Mechanisms of Regulation.” NATURE REVIEWS GENETICS, vol. 24, no. 9, 2023, pp. 590–609, doi:10.1038/s41576-023-00601-0.
APA
Haerinck, J., Goossens, S., & Berx, G. (2023). The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation. NATURE REVIEWS GENETICS, 24(9), 590–609. https://doi.org/10.1038/s41576-023-00601-0
Chicago author-date
Haerinck, Jef, Steven Goossens, and Geert Berx. 2023. “The Epithelial-Mesenchymal Plasticity Landscape: Principles of Design and Mechanisms of Regulation.” NATURE REVIEWS GENETICS 24 (9): 590–609. https://doi.org/10.1038/s41576-023-00601-0.
Chicago author-date (all authors)
Haerinck, Jef, Steven Goossens, and Geert Berx. 2023. “The Epithelial-Mesenchymal Plasticity Landscape: Principles of Design and Mechanisms of Regulation.” NATURE REVIEWS GENETICS 24 (9): 590–609. doi:10.1038/s41576-023-00601-0.
Vancouver
1.
Haerinck J, Goossens S, Berx G. The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation. NATURE REVIEWS GENETICS. 2023;24(9):590–609.
IEEE
[1]
J. Haerinck, S. Goossens, and G. Berx, “The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation,” NATURE REVIEWS GENETICS, vol. 24, no. 9, pp. 590–609, 2023.
@article{01H7T6TASQ04505DC1VAKFGEDZ,
  abstract     = {{Recent systems biology and single-cell approaches have revealed the impact of the microenvironment, lineage specification and cell identity, and the genome on epithelial-mesenchymal plasticity (EMP). In addition, cell memory (hysteresis) and cellular noise can drive stochastic transitions between cell states. The authors review these forces and the regulatory mechanisms that stabilize EMP states or facilitate epithelial-mesenchymal transitions (EMTs).

 Epithelial-mesenchymal plasticity (EMP) enables cells to interconvert between several states across the epithelial-mesenchymal landscape, thereby acquiring hybrid epithelial/mesenchymal phenotypic features. This plasticity is crucial for embryonic development and wound healing, but also underlies the acquisition of several malignant traits during cancer progression. Recent research using systems biology and single-cell profiling methods has provided novel insights into the main forces that shape EMP, which include the microenvironment, lineage specification and cell identity, and the genome. Additionally, key roles have emerged for hysteresis (cell memory) and cellular noise, which can drive stochastic transitions between cell states. Here, we review these forces and the distinct but interwoven layers of regulatory control that stabilize EMP states or facilitate epithelial-mesenchymal transitions (EMTs) and discuss the therapeutic potential of manipulating the EMP landscape.}},
  author       = {{Haerinck, Jef and Goossens, Steven and Berx, Geert}},
  issn         = {{1471-0056}},
  journal      = {{NATURE REVIEWS GENETICS}},
  keywords     = {{DOUBLE-NEGATIVE FEEDBACK,DIAMOND-BLACKFAN ANEMIA,BREAST-CANCER CELLS,TRANSCRIPTION FACTOR SNAIL,CADHERIN GENE-EXPRESSION,CIRCULATING TUMOR-CELLS,FATTY-ACID SYNTHASE,GROWTH-FACTOR,MEMBRANE-FLUIDITY,PROSTATE-CANCER}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{590--609}},
  title        = {{The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation}},
  url          = {{http://doi.org/10.1038/s41576-023-00601-0}},
  volume       = {{24}},
  year         = {{2023}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: