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Urinary bladder phantom mimicking mechanical properties and pressure during filling

Maxime Verstraeten, George Bou Kheir (UGent) , Louis Vande Perre, Romain Raffoul, Javier Chavez Cerda, Alain Delchambre, Thierry Roumeguere, Anne Vanhoestenberghe and Antoine Nonclercq
(2023) BIOMEDICAL PHYSICS & ENGINEERING EXPRESS. 9(5).
Author
Organization
Abstract
Objective. Phantoms that mimic healthy or diseased organ properties can complement animal models for surgical planning, training, and medical device development. If urodynamic studies rely on pressure-volume curves to assess lower urinary tract symptoms, there is an unsatisfied need for a bladder phantom that accurately mimics the bladder stretching capabilities and compliant behaviour during physiological filling. Approach. We demonstrate the suitability of water-soluble 3D-printed moulds as a versatile method to fabricate accurate phantoms with anatomical structures reconstructed from medical images. We report a phantom fabricated with silicone rubber. A wire net limits the silicone expansion to model the cystometric capacity. A mathematical model describes the pressure increase due to passive hyperelastic properties. Main results. The phantom reproduces the bladder's mechanical properties during filling. The pressure-volume curve measured on the phantom is typical of cystometric studies, with a compliance of 25.2 +/- 1 ml cmH(2)O(-1). The root-mean-square error between the theoretical model and experimental data is 2.7 cmH(2)O. The compliance, bladder wall thickness, cystometric capacity and pressure near the cystometric capacity of the phantom can be tuned to mimic various pathologies or human variability. Significance. The manufacturing method is suitable for fabricating bladder and other soft and hollow organ phantoms. The mathematical model provides a method to determine design parameters to model healthy or diseased bladders. Soft hollow organ phantoms can be used to complement animal experimentations for developing and validating medical devices aiming to be anchored on these organs or monitor their activity through pressure and strain measurement.
Keywords
biomedical engineering, functional urology, bladder phantom, 3D-printed water-soluble molds, silicone rubber, bladder pressure monitoring, pressure-volume curve, cystometrogram (CMG), realistic bladder model

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MLA
Verstraeten, Maxime, et al. “Urinary Bladder Phantom Mimicking Mechanical Properties and Pressure during Filling.” BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, vol. 9, no. 5, 2023, doi:10.1088/2057-1976/ace449.
APA
Verstraeten, M., Bou Kheir, G., Vande Perre, L., Raffoul, R., Chavez Cerda, J., Delchambre, A., … Nonclercq, A. (2023). Urinary bladder phantom mimicking mechanical properties and pressure during filling. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 9(5). https://doi.org/10.1088/2057-1976/ace449
Chicago author-date
Verstraeten, Maxime, George Bou Kheir, Louis Vande Perre, Romain Raffoul, Javier Chavez Cerda, Alain Delchambre, Thierry Roumeguere, Anne Vanhoestenberghe, and Antoine Nonclercq. 2023. “Urinary Bladder Phantom Mimicking Mechanical Properties and Pressure during Filling.” BIOMEDICAL PHYSICS & ENGINEERING EXPRESS 9 (5). https://doi.org/10.1088/2057-1976/ace449.
Chicago author-date (all authors)
Verstraeten, Maxime, George Bou Kheir, Louis Vande Perre, Romain Raffoul, Javier Chavez Cerda, Alain Delchambre, Thierry Roumeguere, Anne Vanhoestenberghe, and Antoine Nonclercq. 2023. “Urinary Bladder Phantom Mimicking Mechanical Properties and Pressure during Filling.” BIOMEDICAL PHYSICS & ENGINEERING EXPRESS 9 (5). doi:10.1088/2057-1976/ace449.
Vancouver
1.
Verstraeten M, Bou Kheir G, Vande Perre L, Raffoul R, Chavez Cerda J, Delchambre A, et al. Urinary bladder phantom mimicking mechanical properties and pressure during filling. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS. 2023;9(5).
IEEE
[1]
M. Verstraeten et al., “Urinary bladder phantom mimicking mechanical properties and pressure during filling,” BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, vol. 9, no. 5, 2023.
@article{01H6YFPCE0CM6SJC4DSAQATZPR,
  abstract     = {{Objective. Phantoms that mimic healthy or diseased organ properties can complement animal models for surgical planning, training, and medical device development. If urodynamic studies rely on pressure-volume curves to assess lower urinary tract symptoms, there is an unsatisfied need for a bladder phantom that accurately mimics the bladder stretching capabilities and compliant behaviour during physiological filling. Approach. We demonstrate the suitability of water-soluble 3D-printed moulds as a versatile method to fabricate accurate phantoms with anatomical structures reconstructed from medical images. We report a phantom fabricated with silicone rubber. A wire net limits the silicone expansion to model the cystometric capacity. A mathematical model describes the pressure increase due to passive hyperelastic properties. Main results. The phantom reproduces the bladder's mechanical properties during filling. The pressure-volume curve measured on the phantom is typical of cystometric studies, with a compliance of 25.2 +/- 1 ml cmH(2)O(-1). The root-mean-square error between the theoretical model and experimental data is 2.7 cmH(2)O. The compliance, bladder wall thickness, cystometric capacity and pressure near the cystometric capacity of the phantom can be tuned to mimic various pathologies or human variability. Significance. The manufacturing method is suitable for fabricating bladder and other soft and hollow organ phantoms. The mathematical model provides a method to determine design parameters to model healthy or diseased bladders. Soft hollow organ phantoms can be used to complement animal experimentations for developing and validating medical devices aiming to be anchored on these organs or monitor their activity through pressure and strain measurement.}},
  articleno    = {{055006}},
  author       = {{Verstraeten, Maxime and Bou Kheir, George and Vande Perre, Louis and Raffoul, Romain and Chavez Cerda, Javier and Delchambre, Alain and Roumeguere, Thierry and Vanhoestenberghe, Anne and Nonclercq, Antoine}},
  issn         = {{2057-1976}},
  journal      = {{BIOMEDICAL PHYSICS & ENGINEERING EXPRESS}},
  keywords     = {{biomedical engineering,functional urology,bladder phantom,3D-printed water-soluble molds,silicone rubber,bladder pressure monitoring,pressure-volume curve,cystometrogram (CMG),realistic bladder model}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{14}},
  title        = {{Urinary bladder phantom mimicking mechanical properties and pressure during filling}},
  url          = {{http://doi.org/10.1088/2057-1976/ace449}},
  volume       = {{9}},
  year         = {{2023}},
}
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