@inproceedings{01H6BSWYCQ1W3NECW8ERBXMVK1,
  abstract     = {{N-Heterocyclic carbenes (NHCs) have asserted themselves as a popular and versatile ligand family for the synthesis of organometallic compounds. With applications in catalysis, medicinal chemistry and material sciences, the widespread use of this versatile class of ligands has been a driving force for the development of a sustainable, efficient, and user-friendly route towards their synthesis. The most commonly used synthetic strategy leading to Metal-NHC complexes, has involved the generation of free NHC by deprotonation of the corresponding azolium salt with a strong base (e.g.NaH, KOtBu) and subsequent coordination to a metal. The most significant drawbacks of the free carbene route are the need for strictly anhydrous conditions and incompatibility with the use of metal precursors sensitive to strong bases. Alternatively, the use of weak bases and mild conditions is currently the most sustainable and attractive synthetic approach for the preparation of Late-Transition Metal-NHC complexes. In our work, we translated the latter method to a continuous flow system. This type of technology provides efficient mass and heat transfer rates and allows for the use of small volumes of reagents and in turn enables easy and safe handling of hazardous reagents. Using this setup, complete conversion of the starting cuprate, aurate or palladate species was achieved, yielding the targeted Cu(I), Au(I) and Pd(II)-NHC complexes in excellent yield, without the need for further purification. All reactions examined proceed under extremely mild conditions and make use of technical grade acetone as solvent. The scalability of the process was exemplified in the multigram-scale synthesis of [Cu(IPr)Cl].}},
  author       = {{Simoens, Andreas and Scattolin, Thomas and Cauwenbergh, Thibault and Pisanò, Gianmarco and Cazin, Catherine and Nolan, Steven and Stevens, Christian}},
  booktitle    = {{17th Belgian Organic Synthesis Symposium, Abstracts}},
  language     = {{eng}},
  location     = {{Namur, Belgium}},
  title        = {{Continuous flow synthesis of metal-NHC complexes}},
  year         = {{2022}},
}