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The small intestine : dining table of host–microbiota meetings

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Abstract
Growing evidence suggests the importance of the small intestinal bacteria in the diet-host-microbiota dialogue in various facets of health and disease. Yet, this body site is still poorly explored and its ecology and mechanisms of interaction with the host are just starting to be unraveled. In this review, we describe the current knowledge on the small intestinal ecology, its composition and diversity, and how the intestinal bacteria in homeostatic conditions participate in nutrient digestion and absorption. We illustrate the importance of a controlled bacterial density and of the preservation of absorptive surface for the host's nutritional status. In particular, we discuss these aspects of the small intestinal environment in the framework of two disease conditions, namely small intestinal bacterial overgrowth (SIBO) and short bowel syndrome (SBS). We also detail in vivo, ex vivo, and in vitro models developed to simulate the small intestinal environment, some applied for (diet-)host-bacteria interaction studies. Lastly, we highlight recent technological, medical, and scientific advances applicable to investigate this complex and yet understudied body environment to broaden our knowledge in support of further progress in the medical practice, and to proceed towards the integration of the (small)intestinal bacteria in personalized therapeutic approaches.
Keywords
small intestine, microbiota, nutrition, host-bacteria interaction, SHORT-BOWEL SYNDROME, MUCOSA-ASSOCIATED MICROBIOTA, PROTEIN-COUPLED RECEPTORS, CHAIN FATTY-ACID, BACTERIAL OVERGROWTH, HUMAN GUT, EPITHELIAL-CELLS, GENE-EXPRESSION, ADULT PATIENTS, STEM-CELLS

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Citation

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MLA
Delbaere, Karen, et al. “The Small Intestine : Dining Table of Host–Microbiota Meetings.” FEMS MICROBIOLOGY REVIEWS, vol. 47, no. 3, 2023, doi:10.1093/femsre/fuad022.
APA
Delbaere, K., Roegiers, I., Bron, A., Durif, C., Van de Wiele, T., Blanquet-Diot, S., & Marinelli, L. (2023). The small intestine : dining table of host–microbiota meetings. FEMS MICROBIOLOGY REVIEWS, 47(3). https://doi.org/10.1093/femsre/fuad022
Chicago author-date
Delbaere, Karen, Inez Roegiers, Auriane Bron, Claude Durif, Tom Van de Wiele, Stéphanie Blanquet-Diot, and Ludovica Marinelli. 2023. “The Small Intestine : Dining Table of Host–Microbiota Meetings.” FEMS MICROBIOLOGY REVIEWS 47 (3). https://doi.org/10.1093/femsre/fuad022.
Chicago author-date (all authors)
Delbaere, Karen, Inez Roegiers, Auriane Bron, Claude Durif, Tom Van de Wiele, Stéphanie Blanquet-Diot, and Ludovica Marinelli. 2023. “The Small Intestine : Dining Table of Host–Microbiota Meetings.” FEMS MICROBIOLOGY REVIEWS 47 (3). doi:10.1093/femsre/fuad022.
Vancouver
1.
Delbaere K, Roegiers I, Bron A, Durif C, Van de Wiele T, Blanquet-Diot S, et al. The small intestine : dining table of host–microbiota meetings. FEMS MICROBIOLOGY REVIEWS. 2023;47(3).
IEEE
[1]
K. Delbaere et al., “The small intestine : dining table of host–microbiota meetings,” FEMS MICROBIOLOGY REVIEWS, vol. 47, no. 3, 2023.
@article{01H4DTVBBWS4B1WWETXWR4FR8P,
  abstract     = {{Growing evidence suggests the importance of the small intestinal bacteria in the diet-host-microbiota dialogue in various facets of health and disease. Yet, this body site is still poorly explored and its ecology and mechanisms of interaction with the host are just starting to be unraveled. In this review, we describe the current knowledge on the small intestinal ecology, its composition and diversity, and how the intestinal bacteria in homeostatic conditions participate in nutrient digestion and absorption. We illustrate the importance of a controlled bacterial density and of the preservation of absorptive surface for the host's nutritional status. In particular, we discuss these aspects of the small intestinal environment in the framework of two disease conditions, namely small intestinal bacterial overgrowth (SIBO) and short bowel syndrome (SBS). We also detail in vivo, ex vivo, and in vitro models developed to simulate the small intestinal environment, some applied for (diet-)host-bacteria interaction studies. Lastly, we highlight recent technological, medical, and scientific advances applicable to investigate this complex and yet understudied body environment to broaden our knowledge in support of further progress in the medical practice, and to proceed towards the integration of the (small)intestinal bacteria in personalized therapeutic approaches.}},
  articleno    = {{fuad022}},
  author       = {{Delbaere, Karen and Roegiers, Inez and Bron, Auriane and Durif, Claude and Van de Wiele, Tom and Blanquet-Diot, Stéphanie and Marinelli, Ludovica}},
  issn         = {{0168-6445}},
  journal      = {{FEMS MICROBIOLOGY REVIEWS}},
  keywords     = {{small intestine,microbiota,nutrition,host-bacteria interaction,SHORT-BOWEL SYNDROME,MUCOSA-ASSOCIATED MICROBIOTA,PROTEIN-COUPLED RECEPTORS,CHAIN FATTY-ACID,BACTERIAL OVERGROWTH,HUMAN GUT,EPITHELIAL-CELLS,GENE-EXPRESSION,ADULT PATIENTS,STEM-CELLS}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{32}},
  title        = {{The small intestine : dining table of host–microbiota meetings}},
  url          = {{http://doi.org/10.1093/femsre/fuad022}},
  volume       = {{47}},
  year         = {{2023}},
}

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