STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity
- Author
- Bastiaan Maes, Farzaneh Fayazpour (UGent) , Leen Catrysse (UGent) , Guillaume Lornet (UGent) , Evelien Van De Velde (UGent) , Caroline De Wolf (UGent) , Sofie De Prijck (UGent) , Justine Van Moorleghem (UGent) , Manon Vanheerswynghels (UGent) , Kim Deswarte (UGent) , Benedicte Descamps (UGent) , Christian Vanhove (UGent) , Bart Van der Schueren, Roman Vangoitsenhoven, Hamida Hammad (UGent) , Sophie Janssens (UGent) and Bart Lambrecht (UGent)
- Organization
- Project
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- TAOK3 as a regulator of metabolic responses.
- The role of the Ste20 kinase TAOK3 in metabolism
- A novel role for the IRE1/XBP1 branch in dendritic cells: a signaling cascade matures
- Refining cancer cell death and danger signals for the improvement of immunotherapy
- Understanding the immunological basis of persistent airway obstruction in asthma
- Role of damage associated molecular patterns (DAMPs) in initiation and persistence of chronic airway inflammation
- An integrated approach to unravel eosinophil function in chronic eosinophilic disorders
- Study of the role of the NF-kB-inhibiting protein A20 in diabetes
- Study of the NF-kB inhibitory protein A20 in the liver and liver pathologies like hepatocellular carcinoma
- Dissecting the molecular signals that drive immunogenic versus homeostatic maturation in dendritic cells. An old question revisited.
- Abstract
- Healthy adipose tissue (AT) contains ST2(+) Tregs, ILC2s, and alternatively activated macrophages that are lost in mice or humans on high caloric diet. Understanding how this form of type 2 immunity is regulated could improve treatment of obesity. The STE20 kinase Thousand And One amino acid Kinase-3 (TAOK3) has been linked to obesity in mice and humans, but its precise function is unknown. We found that ST2(+) Tregs are upregulated in visceral epididymal white AT (eWAT) of Taok3(-/-) mice, dependent on IL-33 and the kinase activity of TAOK3. Upon high fat diet feeding, metabolic dysfunction was attenuated in Taok3(-/-) mice. ST2(+) Tregs disappeared from eWAT in obese wild-type mice, but this was not the case in Taok3(-/-) mice. Mechanistically, AT Taok3(-/-) Tregs were intrinsically more responsive to IL-33, through higher expression of ST2, and expressed more PPAR & gamma; and type 2 cytokines. Thus, TAOK3 inhibits adipose tissue Tregs and regulates immunometabolism under excessive caloric intake. Maes et al. reveal an unexpected role of TAOK3 in regulating ST2(+) regulatory T cells in mouse adipose tissue. Absence of TAOK3 sustains Tregs in obesity and improves metabolic dysfunction.
- Keywords
- Immunology, Immunology and Allergy, VISCERAL ADIPOSE-TISSUE, T-REG CELLS, INSULIN-RESISTANCE, PPAR-GAMMA, ACTIVATION, EXPRESSION, FAT, DIFFERENTIATION, INTERLEUKIN-33, ACCUMULATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01H4D6HN6FWM7HAW02GVDENVVY
- MLA
- Maes, Bastiaan, et al. “STE20 Kinase TAOK3 Regulates Type 2 Immunity and Metabolism in Obesity.” JOURNAL OF EXPERIMENTAL MEDICINE, vol. 220, no. 9, 2023, doi:10.1084/jem.20210788.
- APA
- Maes, B., Fayazpour, F., Catrysse, L., Lornet, G., Van De Velde, E., De Wolf, C., … Lambrecht, B. (2023). STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity. JOURNAL OF EXPERIMENTAL MEDICINE, 220(9). https://doi.org/10.1084/jem.20210788
- Chicago author-date
- Maes, Bastiaan, Farzaneh Fayazpour, Leen Catrysse, Guillaume Lornet, Evelien Van De Velde, Caroline De Wolf, Sofie De Prijck, et al. 2023. “STE20 Kinase TAOK3 Regulates Type 2 Immunity and Metabolism in Obesity.” JOURNAL OF EXPERIMENTAL MEDICINE 220 (9). https://doi.org/10.1084/jem.20210788.
- Chicago author-date (all authors)
- Maes, Bastiaan, Farzaneh Fayazpour, Leen Catrysse, Guillaume Lornet, Evelien Van De Velde, Caroline De Wolf, Sofie De Prijck, Justine Van Moorleghem, Manon Vanheerswynghels, Kim Deswarte, Benedicte Descamps, Christian Vanhove, Bart Van der Schueren, Roman Vangoitsenhoven, Hamida Hammad, Sophie Janssens, and Bart Lambrecht. 2023. “STE20 Kinase TAOK3 Regulates Type 2 Immunity and Metabolism in Obesity.” JOURNAL OF EXPERIMENTAL MEDICINE 220 (9). doi:10.1084/jem.20210788.
- Vancouver
- 1.Maes B, Fayazpour F, Catrysse L, Lornet G, Van De Velde E, De Wolf C, et al. STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity. JOURNAL OF EXPERIMENTAL MEDICINE. 2023;220(9).
- IEEE
- [1]B. Maes et al., “STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity,” JOURNAL OF EXPERIMENTAL MEDICINE, vol. 220, no. 9, 2023.
@article{01H4D6HN6FWM7HAW02GVDENVVY,
abstract = {{Healthy adipose tissue (AT) contains ST2(+) Tregs, ILC2s, and alternatively activated macrophages that are lost in mice or humans on high caloric diet. Understanding how this form of type 2 immunity is regulated could improve treatment of obesity. The STE20 kinase Thousand And One amino acid Kinase-3 (TAOK3) has been linked to obesity in mice and humans, but its precise function is unknown. We found that ST2(+) Tregs are upregulated in visceral epididymal white AT (eWAT) of Taok3(-/-) mice, dependent on IL-33 and the kinase activity of TAOK3. Upon high fat diet feeding, metabolic dysfunction was attenuated in Taok3(-/-) mice. ST2(+) Tregs disappeared from eWAT in obese wild-type mice, but this was not the case in Taok3(-/-) mice. Mechanistically, AT Taok3(-/-) Tregs were intrinsically more responsive to IL-33, through higher expression of ST2, and expressed more PPAR & gamma; and type 2 cytokines. Thus, TAOK3 inhibits adipose tissue Tregs and regulates immunometabolism under excessive caloric intake.
Maes et al. reveal an unexpected role of TAOK3 in regulating ST2(+) regulatory T cells in mouse adipose tissue. Absence of TAOK3 sustains Tregs in obesity and improves metabolic dysfunction.}},
articleno = {{e20210788}},
author = {{Maes, Bastiaan and Fayazpour, Farzaneh and Catrysse, Leen and Lornet, Guillaume and Van De Velde, Evelien and De Wolf, Caroline and De Prijck, Sofie and Van Moorleghem, Justine and Vanheerswynghels, Manon and Deswarte, Kim and Descamps, Benedicte and Vanhove, Christian and Van der Schueren, Bart and Vangoitsenhoven, Roman and Hammad, Hamida and Janssens, Sophie and Lambrecht, Bart}},
issn = {{0022-1007}},
journal = {{JOURNAL OF EXPERIMENTAL MEDICINE}},
keywords = {{Immunology,Immunology and Allergy,VISCERAL ADIPOSE-TISSUE,T-REG CELLS,INSULIN-RESISTANCE,PPAR-GAMMA,ACTIVATION,EXPRESSION,FAT,DIFFERENTIATION,INTERLEUKIN-33,ACCUMULATION}},
language = {{eng}},
number = {{9}},
pages = {{14}},
title = {{STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity}},
url = {{http://doi.org/10.1084/jem.20210788}},
volume = {{220}},
year = {{2023}},
}
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