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Dietary teprenone enhances non-specific immunity, antioxidative response and resistance to hypoxia induced oxidative stress in Lateolabrax maculatus

Hongbiao Dong, Suvra Roy, Xiaoting Zheng, Vikash Kumar, Basanta Kumar Das, Yafei Duan, Yongxu Sun and Jiasong Zhang
(2021) AQUACULTURE. 533.
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Abstract
Persistent hypoxic or low-oxygen conditions in aquatic systems are becoming more frequent worldwide, causing large-scale mortalities to the aquaculture animals. Hence, it would be of great benefit to search for natural compounds that are clinically safe, yet able to induce host health and antioxidant defence system. In the experiment, Lateolabrax maculatus were fed with ketone compound teprenone and subsequently exposed to hypoxia condition. Afterwards, the effect of teprenone on the antioxidative response, non-specific immunity and hypoxia induced oxidative stress were investigated. We found that dietary supplementation of teprenone at 200 mg/kg (HT200), 400 mg/kg (HT400) and 800 mg/kg (HT800) significantly increase the total antioxidant capacity (T-AOC) during hypoxia stress. While, lower values of malondialdehyde (MDA) content, an indicator of oxidative stress, were recorded in teprenone supplemented groups. In addition, upregulation of non-specific immune parameters including lysozyme (LZM), Hsp70 and Hsp90 was observed in L.maculatus. We further demonstrated that teprenone supplementation protects L.maculatus from hypoxia and oxidative stress generated apoptosis. The pro-apoptotic signalling molecules, i.e., cytochrome C (Cty-C), caspase-9 and caspase-3 production were significantly decreased in response to teprenone supplementation during the hypoxia stress. In contrast, the anti-apoptotic response, BCL-2 gene expression, was significantly increased. We have shown that dietary teprenone induces innate immunity and antioxidative response and protects L.maculatus against hypoxia induced-oxidative stress and apoptosis; therefore, suggesting their possible role to manage the stressful condition, in particular, hypoxia stress in aquaculture.
Keywords
Hypoxia, Lateolabrax maculatus, Oxidative stress, Teprenone, Antioxidative response, Innate immunity, CHINESE SEA BASS, SELENIUM NANOPARTICLES, GROWTH-PERFORMANCE, FISH, BIOCHEMISTRY, TOLERANCE, JUVENILES, APOPTOSIS, JAPANESE

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MLA
Dong, Hongbiao, et al. “Dietary Teprenone Enhances Non-Specific Immunity, Antioxidative Response and Resistance to Hypoxia Induced Oxidative Stress in Lateolabrax Maculatus.” AQUACULTURE, vol. 533, 2021, doi:10.1016/j.aquaculture.2020.736126.
APA
Dong, H., Roy, S., Zheng, X., Kumar, V., Das, B. K., Duan, Y., … Zhang, J. (2021). Dietary teprenone enhances non-specific immunity, antioxidative response and resistance to hypoxia induced oxidative stress in Lateolabrax maculatus. AQUACULTURE, 533. https://doi.org/10.1016/j.aquaculture.2020.736126
Chicago author-date
Dong, Hongbiao, Suvra Roy, Xiaoting Zheng, Vikash Kumar, Basanta Kumar Das, Yafei Duan, Yongxu Sun, and Jiasong Zhang. 2021. “Dietary Teprenone Enhances Non-Specific Immunity, Antioxidative Response and Resistance to Hypoxia Induced Oxidative Stress in Lateolabrax Maculatus.” AQUACULTURE 533. https://doi.org/10.1016/j.aquaculture.2020.736126.
Chicago author-date (all authors)
Dong, Hongbiao, Suvra Roy, Xiaoting Zheng, Vikash Kumar, Basanta Kumar Das, Yafei Duan, Yongxu Sun, and Jiasong Zhang. 2021. “Dietary Teprenone Enhances Non-Specific Immunity, Antioxidative Response and Resistance to Hypoxia Induced Oxidative Stress in Lateolabrax Maculatus.” AQUACULTURE 533. doi:10.1016/j.aquaculture.2020.736126.
Vancouver
1.
Dong H, Roy S, Zheng X, Kumar V, Das BK, Duan Y, et al. Dietary teprenone enhances non-specific immunity, antioxidative response and resistance to hypoxia induced oxidative stress in Lateolabrax maculatus. AQUACULTURE. 2021;533.
IEEE
[1]
H. Dong et al., “Dietary teprenone enhances non-specific immunity, antioxidative response and resistance to hypoxia induced oxidative stress in Lateolabrax maculatus,” AQUACULTURE, vol. 533, 2021.
@article{01H42EMKXV26RN5R9R6H9S86HY,
  abstract     = {{Persistent hypoxic or low-oxygen conditions in aquatic systems are becoming more frequent worldwide, causing large-scale mortalities to the aquaculture animals. Hence, it would be of great benefit to search for natural compounds that are clinically safe, yet able to induce host health and antioxidant defence system. In the experiment, Lateolabrax maculatus were fed with ketone compound teprenone and subsequently exposed to hypoxia condition. Afterwards, the effect of teprenone on the antioxidative response, non-specific immunity and hypoxia induced oxidative stress were investigated. We found that dietary supplementation of teprenone at 200 mg/kg (HT200), 400 mg/kg (HT400) and 800 mg/kg (HT800) significantly increase the total antioxidant capacity (T-AOC) during hypoxia stress. While, lower values of malondialdehyde (MDA) content, an indicator of oxidative stress, were recorded in teprenone supplemented groups. In addition, upregulation of non-specific immune parameters including lysozyme (LZM), Hsp70 and Hsp90 was observed in L.maculatus. We further demonstrated that teprenone supplementation protects L.maculatus from hypoxia and oxidative stress generated apoptosis. The pro-apoptotic signalling molecules, i.e., cytochrome C (Cty-C), caspase-9 and caspase-3 production were significantly decreased in response to teprenone supplementation during the hypoxia stress. In contrast, the anti-apoptotic response, BCL-2 gene expression, was significantly increased. We have shown that dietary teprenone induces innate immunity and antioxidative response and protects L.maculatus against hypoxia induced-oxidative stress and apoptosis; therefore, suggesting their possible role to manage the stressful condition, in particular, hypoxia stress in aquaculture.}},
  articleno    = {{736126}},
  author       = {{Dong, Hongbiao and Roy, Suvra and Zheng, Xiaoting and Kumar, Vikash and Das, Basanta Kumar and Duan, Yafei and Sun, Yongxu and Zhang, Jiasong}},
  issn         = {{0044-8486}},
  journal      = {{AQUACULTURE}},
  keywords     = {{Hypoxia,Lateolabrax maculatus,Oxidative stress,Teprenone,Antioxidative response,Innate immunity,CHINESE SEA BASS,SELENIUM NANOPARTICLES,GROWTH-PERFORMANCE,FISH,BIOCHEMISTRY,TOLERANCE,JUVENILES,APOPTOSIS,JAPANESE}},
  language     = {{eng}},
  pages        = {{8}},
  title        = {{Dietary teprenone enhances non-specific immunity, antioxidative response and resistance to hypoxia induced oxidative stress in Lateolabrax maculatus}},
  url          = {{http://doi.org/10.1016/j.aquaculture.2020.736126}},
  volume       = {{533}},
  year         = {{2021}},
}
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