- Author
- Nick Deploey (UGent) , Laura Van Moortel (UGent) , Inez Rogatsky, Frank Peelman (UGent) and Karolien De Bosscher (UGent)
- Organization
- Project
- Abstract
- The glucocorticoid receptor & alpha; (GR & alpha;) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects and therapy resistance limit GR's therapeutic potential, emphasizing the importance of resolving all of GR's context-specific action mechanisms. Fortunately, the understanding of GR structure, conformation, and stoichiometry in the different GR-controlled biological pathways is now gradually increasing. This information will be crucial to close knowledge gaps on GR function. In this review, we focus on the various domains and mechanisms of action of GR, all from a structural perspective.
- Keywords
- General Medicine, ligand-binding domain, DNA-binding domain, N-terminal domain, nuclear receptor, structure, glucocorticoids, glucocorticoid receptor
Downloads
-
cells-12-01636-with-cover.pdf
- full text (Published version)
- |
- open access
- |
- |
- 3.26 MB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01H40X0D1W89FBB679P0D27ZCE
- MLA
- Deploey, Nick, et al. “The Biologist’s Guide to the Glucocorticoid Receptor’s Structure.” CELLS, vol. 12, no. 12, MDPI AG, 2023, doi:10.3390/cells12121636.
- APA
- Deploey, N., Van Moortel, L., Rogatsky, I., Peelman, F., & De Bosscher, K. (2023). The biologist’s guide to the glucocorticoid receptor’s structure. CELLS, 12(12). https://doi.org/10.3390/cells12121636
- Chicago author-date
- Deploey, Nick, Laura Van Moortel, Inez Rogatsky, Frank Peelman, and Karolien De Bosscher. 2023. “The Biologist’s Guide to the Glucocorticoid Receptor’s Structure.” CELLS 12 (12). https://doi.org/10.3390/cells12121636.
- Chicago author-date (all authors)
- Deploey, Nick, Laura Van Moortel, Inez Rogatsky, Frank Peelman, and Karolien De Bosscher. 2023. “The Biologist’s Guide to the Glucocorticoid Receptor’s Structure.” CELLS 12 (12). doi:10.3390/cells12121636.
- Vancouver
- 1.Deploey N, Van Moortel L, Rogatsky I, Peelman F, De Bosscher K. The biologist’s guide to the glucocorticoid receptor’s structure. CELLS. 2023;12(12).
- IEEE
- [1]N. Deploey, L. Van Moortel, I. Rogatsky, F. Peelman, and K. De Bosscher, “The biologist’s guide to the glucocorticoid receptor’s structure,” CELLS, vol. 12, no. 12, 2023.
@article{01H40X0D1W89FBB679P0D27ZCE,
abstract = {{The glucocorticoid receptor & alpha; (GR & alpha;) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects and therapy resistance limit GR's therapeutic potential, emphasizing the importance of resolving all of GR's context-specific action mechanisms. Fortunately, the understanding of GR structure, conformation, and stoichiometry in the different GR-controlled biological pathways is now gradually increasing. This information will be crucial to close knowledge gaps on GR function. In this review, we focus on the various domains and mechanisms of action of GR, all from a structural perspective.}},
articleno = {{1636}},
author = {{Deploey, Nick and Van Moortel, Laura and Rogatsky, Inez and Peelman, Frank and De Bosscher, Karolien}},
issn = {{2073-4409}},
journal = {{CELLS}},
keywords = {{General Medicine,ligand-binding domain,DNA-binding domain,N-terminal domain,nuclear receptor,structure,glucocorticoids,glucocorticoid receptor}},
language = {{eng}},
number = {{12}},
pages = {{38}},
publisher = {{MDPI AG}},
title = {{The biologist’s guide to the glucocorticoid receptor’s structure}},
url = {{http://doi.org/10.3390/cells12121636}},
volume = {{12}},
year = {{2023}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: