- Author
- Geert van Loo (UGent) and Mathieu Bertrand (UGent)
- Organization
- Project
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- Targeting the mevalonate pathway to treat inflammatory diseases
- Investigating itaconic acid as a critical immunometabolite in Influenza and RSV infections
- Study of microbiota-host interactions during colon cancer development using a unique microbiome dependent mouse model
- Host-microbe interaction in intestinal homeostasis: unravelling the mechanisms involved in the onset of multiple inflammation-related diseases
- Charcot Stichting - Fund 2022: Investigating itaconic acid as a critical immunometabolite in multiple sclerosis
- Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy
- Study of RIPK1 involvement and regulation in inflammatory and infectious diseases
- Cell Death Regulation and Role in Infection and Inflammatory Diseases
- Cell death activity regulation in inflammation and cancer
- Identification of RIPK1 substrates and elucidation of their action mechanism in inflammation
- MOlecular mechanisms of cellular DEath and Life decisions in Inflammation, Degeneration and Infection
- Study of the molecular pathways through which linear (de)ubiquitination governs skin inflammation and aberrant epidermal stem cell activation
- Abstract
- Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory and autoimmune pathologies. In recent years, it became clear that TNF drives inflammatory responses not only directly by inducing inflammatory gene expression but also indirectly by inducing cell death, instigating inflammatory immune reactions and disease development. Hence, inhibitors of cell death are being considered as a new therapy for TNF-dependent inflammatory diseases. Tumour necrosis factor (TNF) drives inflammatory responses directly by inducing inflammatory gene expression and also indirectly by inducing cell death. This article reviews the various TNF-induced cell death pathways, their mode of execution and the molecular checkpoints that control them, which is revealing new opportunities for the treatment of TNF-mediated diseases.
- Keywords
- TUMOR-NECROSIS-FACTOR, NF-KAPPA-B, FACTOR-ALPHA CA2, CELL-DEATH, RHEUMATOID-ARTHRITIS, MOLECULAR-CLONING, LINEAR UBIQUITIN, EPIDERMAL-KERATINOCYTES, MONOCLONAL-ANTIBODY, MEDIATED APOPTOSIS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01H3W2W6QTJGC2SM6PBQ0Q229R
- MLA
- van Loo, Geert, and Mathieu Bertrand. “Death by TNF : A Road to Inflammation.” NATURE REVIEWS IMMUNOLOGY, vol. 23, no. 5, 2023, pp. 289–303, doi:10.1038/s41577-022-00792-3.
- APA
- van Loo, G., & Bertrand, M. (2023). Death by TNF : a road to inflammation. NATURE REVIEWS IMMUNOLOGY, 23(5), 289–303. https://doi.org/10.1038/s41577-022-00792-3
- Chicago author-date
- Loo, Geert van, and Mathieu Bertrand. 2023. “Death by TNF : A Road to Inflammation.” NATURE REVIEWS IMMUNOLOGY 23 (5): 289–303. https://doi.org/10.1038/s41577-022-00792-3.
- Chicago author-date (all authors)
- van Loo, Geert, and Mathieu Bertrand. 2023. “Death by TNF : A Road to Inflammation.” NATURE REVIEWS IMMUNOLOGY 23 (5): 289–303. doi:10.1038/s41577-022-00792-3.
- Vancouver
- 1.van Loo G, Bertrand M. Death by TNF : a road to inflammation. NATURE REVIEWS IMMUNOLOGY. 2023;23(5):289–303.
- IEEE
- [1]G. van Loo and M. Bertrand, “Death by TNF : a road to inflammation,” NATURE REVIEWS IMMUNOLOGY, vol. 23, no. 5, pp. 289–303, 2023.
@article{01H3W2W6QTJGC2SM6PBQ0Q229R,
abstract = {{Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory and autoimmune pathologies. In recent years, it became clear that TNF drives inflammatory responses not only directly by inducing inflammatory gene expression but also indirectly by inducing cell death, instigating inflammatory immune reactions and disease development. Hence, inhibitors of cell death are being considered as a new therapy for TNF-dependent inflammatory diseases.
Tumour necrosis factor (TNF) drives inflammatory responses directly by inducing inflammatory gene expression and also indirectly by inducing cell death. This article reviews the various TNF-induced cell death pathways, their mode of execution and the molecular checkpoints that control them, which is revealing new opportunities for the treatment of TNF-mediated diseases.}},
author = {{van Loo, Geert and Bertrand, Mathieu}},
issn = {{1474-1733}},
journal = {{NATURE REVIEWS IMMUNOLOGY}},
keywords = {{TUMOR-NECROSIS-FACTOR,NF-KAPPA-B,FACTOR-ALPHA CA2,CELL-DEATH,RHEUMATOID-ARTHRITIS,MOLECULAR-CLONING,LINEAR UBIQUITIN,EPIDERMAL-KERATINOCYTES,MONOCLONAL-ANTIBODY,MEDIATED APOPTOSIS}},
language = {{eng}},
number = {{5}},
pages = {{289--303}},
title = {{Death by TNF : a road to inflammation}},
url = {{http://doi.org/10.1038/s41577-022-00792-3}},
volume = {{23}},
year = {{2023}},
}
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