Towards dsRNA-integrated protection of medical Cannabis crops : considering human safety, recent- and developing RNAi methods, and research inroads
- Author
- Jonathan Willow, Ana I. I. Silva, Nji Tizi Clauvis Taning (UGent) , Guy Smagghe (UGent) and Eve Veromann
- Organization
- Project
- Abstract
- Owing to the expanding industry of medical Cannabis, we discuss recent milestones in RNA interference (RNAi)-based crop protection research and development that are transferable to medical Cannabis cultivation. Recent and prospective increases in pest pressure in both indoor and outdoor Cannabis production systems, and the need for effective nonchemical pest control technologies (particularly crucial in the context of cultivating plants for medical purposes), are discussed. We support the idea that developing RNAi tactics towards protection of medical Cannabis could play a major role in maximizing success in this continuously expanding industry. However, there remain critical knowledge gaps, especially with regard to RNA pesticide biosafety from a human toxicological viewpoint, as a result of the medical context of Cannabis product use. Furthermore, efforts are needed to optimize transformation and micropropagation of Cannabis plants, examine cutting edge RNAi techniques for various Cannabis-pest scenarios, and investigate the combined application of RNAi- and biological control tactics in medical Cannabis cultivation.
- Keywords
- DOUBLE-STRANDED-RNA, TARGETING VACUOLAR ATPASE, ORAL TOXICITY EVALUATION, SMALL INTERFERING RNAS, GENE, PAIN, medicinal plants, RNA, biopesticide, pest management, disease resistance, pesticide safety
Downloads
-
Pest Management Science - 2022 - Willow - Towards dsRNA‐integrated protection of medical Cannabis crops considering human.pdf
- full text (Published version)
- |
- open access
- |
- |
- 400.01 KB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01H3HSSJ5287AZ3C4R3YX6QTZA
- MLA
- Willow, Jonathan, et al. “Towards DsRNA-Integrated Protection of Medical Cannabis Crops : Considering Human Safety, Recent- and Developing RNAi Methods, and Research Inroads.” PEST MANAGEMENT SCIENCE, vol. 79, no. 4, 2023, pp. 1267–72, doi:10.1002/ps.7323.
- APA
- Willow, J., Silva, A. I. I., Taning, N. T. C., Smagghe, G., & Veromann, E. (2023). Towards dsRNA-integrated protection of medical Cannabis crops : considering human safety, recent- and developing RNAi methods, and research inroads. PEST MANAGEMENT SCIENCE, 79(4), 1267–1272. https://doi.org/10.1002/ps.7323
- Chicago author-date
- Willow, Jonathan, Ana I. I. Silva, Nji Tizi Clauvis Taning, Guy Smagghe, and Eve Veromann. 2023. “Towards DsRNA-Integrated Protection of Medical Cannabis Crops : Considering Human Safety, Recent- and Developing RNAi Methods, and Research Inroads.” PEST MANAGEMENT SCIENCE 79 (4): 1267–72. https://doi.org/10.1002/ps.7323.
- Chicago author-date (all authors)
- Willow, Jonathan, Ana I. I. Silva, Nji Tizi Clauvis Taning, Guy Smagghe, and Eve Veromann. 2023. “Towards DsRNA-Integrated Protection of Medical Cannabis Crops : Considering Human Safety, Recent- and Developing RNAi Methods, and Research Inroads.” PEST MANAGEMENT SCIENCE 79 (4): 1267–1272. doi:10.1002/ps.7323.
- Vancouver
- 1.Willow J, Silva AII, Taning NTC, Smagghe G, Veromann E. Towards dsRNA-integrated protection of medical Cannabis crops : considering human safety, recent- and developing RNAi methods, and research inroads. PEST MANAGEMENT SCIENCE. 2023;79(4):1267–72.
- IEEE
- [1]J. Willow, A. I. I. Silva, N. T. C. Taning, G. Smagghe, and E. Veromann, “Towards dsRNA-integrated protection of medical Cannabis crops : considering human safety, recent- and developing RNAi methods, and research inroads,” PEST MANAGEMENT SCIENCE, vol. 79, no. 4, pp. 1267–1272, 2023.
@article{01H3HSSJ5287AZ3C4R3YX6QTZA,
abstract = {{Owing to the expanding industry of medical Cannabis, we discuss recent milestones in RNA interference (RNAi)-based crop protection research and development that are transferable to medical Cannabis cultivation. Recent and prospective increases in pest pressure in both indoor and outdoor Cannabis production systems, and the need for effective nonchemical pest control technologies (particularly crucial in the context of cultivating plants for medical purposes), are discussed. We support the idea that developing RNAi tactics towards protection of medical Cannabis could play a major role in maximizing success in this continuously expanding industry. However, there remain critical knowledge gaps, especially with regard to RNA pesticide biosafety from a human toxicological viewpoint, as a result of the medical context of Cannabis product use. Furthermore, efforts are needed to optimize transformation and micropropagation of Cannabis plants, examine cutting edge RNAi techniques for various Cannabis-pest scenarios, and investigate the combined application of RNAi- and biological control tactics in medical Cannabis cultivation.}},
author = {{Willow, Jonathan and Silva, Ana I. I. and Taning, Nji Tizi Clauvis and Smagghe, Guy and Veromann, Eve}},
issn = {{1526-498X}},
journal = {{PEST MANAGEMENT SCIENCE}},
keywords = {{DOUBLE-STRANDED-RNA,TARGETING VACUOLAR ATPASE,ORAL TOXICITY EVALUATION,SMALL INTERFERING RNAS,GENE,PAIN,medicinal plants,RNA,biopesticide,pest management,disease resistance,pesticide safety}},
language = {{eng}},
number = {{4}},
pages = {{1267--1272}},
title = {{Towards dsRNA-integrated protection of medical Cannabis crops : considering human safety, recent- and developing RNAi methods, and research inroads}},
url = {{http://doi.org/10.1002/ps.7323}},
volume = {{79}},
year = {{2023}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: