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Structural connectome alterations in anxious dogs : a DTI-based study

Qinyuan Chen (UGent) , Yangfeng Xu (UGent) , Emma Christiaen, Guo-Rong Wu, Sara De Witte (UGent) , Christian Vanhove (UGent) , Jimmy Saunders (UGent) , Kathelijne Peremans (UGent) and Chris Baeken (UGent)
(2023) SCIENTIFIC REPORTS. 13(1).
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Abstract
Anxiety and fear are dysfunctional behaviors commonly observed in domesticated dogs. Although dogs and humans share psychopathological similarities, little is known about how dysfunctional fear behaviors are represented in brain networks in dogs diagnosed with anxiety disorders. A combination of diffusion tensor imaging (DTI) and graph theory was used to investigate the underlying structural connections of dysfunctional anxiety in anxious dogs and compared with healthy dogs with normal behavior. The degree of anxiety was assessed using the Canine Behavioral Assessment & Research Questionnaire (C-BARQ), a widely used, validated questionnaire for abnormal behaviors in dogs. Anxious dogs showed significantly decreased clustering coefficient (Cp), decreased global efficiency (Eglob), and increased small-worldness (σ) when compared with healthy dogs. The nodal parameters that differed between the anxious dogs and healthy dogs were mainly located in the posterior part of the brain, including the occipital lobe, posterior cingulate gyrus, hippocampus, mesencephalon, and cerebellum. Furthermore, the nodal degree (Ki) of the left cerebellum was significantly negatively correlated with “excitability” in the C-BARQ of anxious dogs. These findings could contribute to the understanding of a disrupted brain structural connectome underlying the pathological mechanisms of anxiety-related disorders in dogs.
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Multidisciplinary

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MLA
Chen, Qinyuan, et al. “Structural Connectome Alterations in Anxious Dogs : A DTI-Based Study.” SCIENTIFIC REPORTS, vol. 13, no. 1, 2023, doi:10.1038/s41598-023-37121-0.
APA
Chen, Q., Xu, Y., Christiaen, E., Wu, G.-R., De Witte, S., Vanhove, C., … Baeken, C. (2023). Structural connectome alterations in anxious dogs : a DTI-based study. SCIENTIFIC REPORTS, 13(1). https://doi.org/10.1038/s41598-023-37121-0
Chicago author-date
Chen, Qinyuan, Yangfeng Xu, Emma Christiaen, Guo-Rong Wu, Sara De Witte, Christian Vanhove, Jimmy Saunders, Kathelijne Peremans, and Chris Baeken. 2023. “Structural Connectome Alterations in Anxious Dogs : A DTI-Based Study.” SCIENTIFIC REPORTS 13 (1). https://doi.org/10.1038/s41598-023-37121-0.
Chicago author-date (all authors)
Chen, Qinyuan, Yangfeng Xu, Emma Christiaen, Guo-Rong Wu, Sara De Witte, Christian Vanhove, Jimmy Saunders, Kathelijne Peremans, and Chris Baeken. 2023. “Structural Connectome Alterations in Anxious Dogs : A DTI-Based Study.” SCIENTIFIC REPORTS 13 (1). doi:10.1038/s41598-023-37121-0.
Vancouver
1.
Chen Q, Xu Y, Christiaen E, Wu G-R, De Witte S, Vanhove C, et al. Structural connectome alterations in anxious dogs : a DTI-based study. SCIENTIFIC REPORTS. 2023;13(1).
IEEE
[1]
Q. Chen et al., “Structural connectome alterations in anxious dogs : a DTI-based study,” SCIENTIFIC REPORTS, vol. 13, no. 1, 2023.
@article{01H3EGN3W52BH4F398WNMG4B2K,
  abstract     = {{Anxiety and fear are dysfunctional behaviors commonly observed in domesticated dogs. Although dogs and humans share psychopathological similarities, little is known about how dysfunctional fear behaviors are represented in brain networks in dogs diagnosed with anxiety disorders. A combination of diffusion tensor imaging (DTI) and graph theory was used to investigate the underlying structural connections of dysfunctional anxiety in anxious dogs and compared with healthy dogs with normal behavior. The degree of anxiety was assessed using the Canine Behavioral Assessment & Research Questionnaire (C-BARQ), a widely used, validated questionnaire for abnormal behaviors in dogs. Anxious dogs showed significantly decreased clustering coefficient (Cp), decreased global efficiency (Eglob), and increased small-worldness (σ) when compared with healthy dogs. The nodal parameters that differed between the anxious dogs and healthy dogs were mainly located in the posterior part of the brain, including the occipital lobe, posterior cingulate gyrus, hippocampus, mesencephalon, and cerebellum. Furthermore, the nodal degree (Ki) of the left cerebellum was significantly negatively correlated with “excitability” in the C-BARQ of anxious dogs. These findings could contribute to the understanding of a disrupted brain structural connectome underlying the pathological mechanisms of anxiety-related disorders in dogs.}},
  articleno    = {{9946}},
  author       = {{Chen, Qinyuan and Xu, Yangfeng and Christiaen, Emma and Wu, Guo-Rong and De Witte, Sara and Vanhove, Christian and Saunders, Jimmy and Peremans, Kathelijne and Baeken, Chris}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{Multidisciplinary}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{11}},
  title        = {{Structural connectome alterations in anxious dogs : a DTI-based study}},
  url          = {{http://doi.org/10.1038/s41598-023-37121-0}},
  volume       = {{13}},
  year         = {{2023}},
}
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