Mechanobiology of ferroptotic cancer cells as a novel 'eat-me' signal : regulating efferocytosis through layer-by-layer coating
- Author
- Louis Van der Meeren (UGent) , Iuliia Efimova (UGent) , Robin Demuynck (UGent) , Bogdan Parakhonskiy (UGent) , Dmitri Krysko (UGent) and Andre Skirtach (UGent)
- Organization
- Project
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- Mechanobiology control of immunogenic cell death by bio-polymers for cancer therapy
- High intensity focused ultrasound and mRNA nanomedicines: a new strategy to induce and boost anti-tumor immunity
- EncapsuLatIon of FErropTotic cells into Immunogenic MicrocapsulEs: a deadly combination to cancer (LIFETIME)
- Triple punch against melanoma: photodynamic therapy, immunogenic cell death and photothermal ablation
- Harnessing tumor acidosis and immunogenic ferroptosis for an innovative treatment of peritoneal carcinomatosis with PUFA-loaded nanovesicles
- Targeting phosphatidylserine to enhance immunogenicity of regulated necrotic cancer cells by microcapsules.
- The impact of tumour vasculature on the immunogenicity of ferroptosis in tumour spheroids.
- Atomic force microscopy (AFM) - nanobiotechnology gebaseerd platform voor het bereiken van de dynamiek van afzonderlijke moleculen tot veelzijdige materialen en celmechanica
- PASCell: parameter activated sorting of cells
- Abstract
- The importance of the clearance of dead cells is shown to have a regulatory role for normal tissue homeostasis and for the modulation of immune responses. However, how mechanobiological properties of dead cells affect efferocytosis remains largely unknown. Here, it is reported that the Young's modulus of cancer cells undergoing ferroptosis is reduced. To modulate their Young's modulus a layer-by-layer (LbL) nanocoating is developed. Scanning electron and fluorescence microscopy confirm coating efficiency of ferroptotic cells while atomic force microscopy reveals encapsulation of the dead cells increases their Young's modulus dependent on the number of applied LbL layers which increases their efferocytosis by primary macrophages. This work demonstrates the crucial role of mechanobiology of dead cells in regulating their efferocytosis by macrophages which can be exploited for the development of novel therapeutic strategies for diseases where modulation of efferocytosis can be potentially beneficial and for the design of drug delivery systems for cancer therapy.
- Keywords
- Atomic force microscopy, Efferocytosis, Ferroptosis, Immunogenic cell death, Mechanobiology, phagocytosis, cell death, regulated cell death, Layer-by-Layer Coating, cancer, nanocoating, Young's modulus, macrophages, phagocytes, atomic force microscopy, efferocytosis, ferroptosis, immunogenic cell death, mechanobiology, INTERNALIZATION, MICROCAPSULES, ENCAPSULATION, PHAGOCYTOSIS, MACROPHAGES, MECHANISMS, CAPSULES, BUILDUP, SPRAY, AFM
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01H2YY1QHFNXZPYDR166SVW3MA
- MLA
- Van der Meeren, Louis, et al. “Mechanobiology of Ferroptotic Cancer Cells as a Novel ‘eat-Me’ Signal : Regulating Efferocytosis through Layer-by-Layer Coating.” ADVANCED HEALTHCARE MATERIALS, vol. 12, no. 28, 2023, doi:10.1002/adhm.202301025.
- APA
- Van der Meeren, L., Efimova, I., Demuynck, R., Parakhonskiy, B., Krysko, D., & Skirtach, A. (2023). Mechanobiology of ferroptotic cancer cells as a novel “eat-me” signal : regulating efferocytosis through layer-by-layer coating. ADVANCED HEALTHCARE MATERIALS, 12(28). https://doi.org/10.1002/adhm.202301025
- Chicago author-date
- Van der Meeren, Louis, Iuliia Efimova, Robin Demuynck, Bogdan Parakhonskiy, Dmitri Krysko, and Andre Skirtach. 2023. “Mechanobiology of Ferroptotic Cancer Cells as a Novel ‘eat-Me’ Signal : Regulating Efferocytosis through Layer-by-Layer Coating.” ADVANCED HEALTHCARE MATERIALS 12 (28). https://doi.org/10.1002/adhm.202301025.
- Chicago author-date (all authors)
- Van der Meeren, Louis, Iuliia Efimova, Robin Demuynck, Bogdan Parakhonskiy, Dmitri Krysko, and Andre Skirtach. 2023. “Mechanobiology of Ferroptotic Cancer Cells as a Novel ‘eat-Me’ Signal : Regulating Efferocytosis through Layer-by-Layer Coating.” ADVANCED HEALTHCARE MATERIALS 12 (28). doi:10.1002/adhm.202301025.
- Vancouver
- 1.Van der Meeren L, Efimova I, Demuynck R, Parakhonskiy B, Krysko D, Skirtach A. Mechanobiology of ferroptotic cancer cells as a novel “eat-me” signal : regulating efferocytosis through layer-by-layer coating. ADVANCED HEALTHCARE MATERIALS. 2023;12(28).
- IEEE
- [1]L. Van der Meeren, I. Efimova, R. Demuynck, B. Parakhonskiy, D. Krysko, and A. Skirtach, “Mechanobiology of ferroptotic cancer cells as a novel ‘eat-me’ signal : regulating efferocytosis through layer-by-layer coating,” ADVANCED HEALTHCARE MATERIALS, vol. 12, no. 28, 2023.
@article{01H2YY1QHFNXZPYDR166SVW3MA,
abstract = {{The importance of the clearance of dead cells is shown to have a regulatory role for normal tissue homeostasis and for the modulation of immune responses. However, how mechanobiological properties of dead cells affect efferocytosis remains largely unknown. Here, it is reported that the Young's modulus of cancer cells undergoing ferroptosis is reduced. To modulate their Young's modulus a layer-by-layer (LbL) nanocoating is developed. Scanning electron and fluorescence microscopy confirm coating efficiency of ferroptotic cells while atomic force microscopy reveals encapsulation of the dead cells increases their Young's modulus dependent on the number of applied LbL layers which increases their efferocytosis by primary macrophages. This work demonstrates the crucial role of mechanobiology of dead cells in regulating their efferocytosis by macrophages which can be exploited for the development of novel therapeutic strategies for diseases where modulation of efferocytosis can be potentially beneficial and for the design of drug delivery systems for cancer therapy.}},
articleno = {{2301025}},
author = {{Van der Meeren, Louis and Efimova, Iuliia and Demuynck, Robin and Parakhonskiy, Bogdan and Krysko, Dmitri and Skirtach, Andre}},
issn = {{2192-2640}},
journal = {{ADVANCED HEALTHCARE MATERIALS}},
keywords = {{Atomic force microscopy,Efferocytosis,Ferroptosis,Immunogenic cell death,Mechanobiology,phagocytosis,cell death,regulated cell death,Layer-by-Layer Coating,cancer,nanocoating,Young's modulus,macrophages,phagocytes,atomic force microscopy,efferocytosis,ferroptosis,immunogenic cell death,mechanobiology,INTERNALIZATION,MICROCAPSULES,ENCAPSULATION,PHAGOCYTOSIS,MACROPHAGES,MECHANISMS,CAPSULES,BUILDUP,SPRAY,AFM}},
language = {{eng}},
number = {{28}},
pages = {{13}},
title = {{Mechanobiology of ferroptotic cancer cells as a novel 'eat-me' signal : regulating efferocytosis through layer-by-layer coating}},
url = {{http://doi.org/10.1002/adhm.202301025}},
volume = {{12}},
year = {{2023}},
}
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