@article{01H19E67SBY41ZMYA33GRGSGA9,
  abstract     = {{Pupil size covaries with the diffusion rate of the cholinergic and noradrenergic neurons throughout the brain, which are essential to arousal. Recent findings suggest that slow pupil fluctuations during locomotion are an index of sustained activity in cholinergic axons, whereas phasic dilations are related to the activity of noradrenergic axons. Here, we investigated movement induced arousal (i.e., by singing and swaying to music), hypothesising that actively engaging in musical behaviour will provoke stronger emotional engagement in participants and lead to different qualitative patterns of tonic and phasic pupil activity. A challenge in the analysis of pupil data is the turbulent behaviour of pupil diameter due to exogenous ocular activity commonly encountered during motor tasks and the high variability typically found between individuals. To address this, we developed an algorithm that adaptively estimates and removes pupil responses to ocular events, as well as a functional data methodology, derived from Pfaffs' generalised arousal, that provides a new statistical dimension on how pupil data can be interpreted according to putative neuromodulatory signalling. We found that actively engaging in singing enhanced slow cholinergic-related pupil dilations and having the opportunity to move your body while performing amplified the effect of singing on pupil activity. Phasic pupil oscillations during motor execution attenuated in time, which is often interpreted as a measure of sense of agency over movement.}},
  author       = {{Vidal Badia, Marc and Onderdijk, Kelsey E. and Aguilera, Ana M. and Six, Joren and Maes, Pieter-Jan and Fritz, Thomas and Leman, Marc}},
  issn         = {{0953-816X}},
  journal      = {{EUROPEAN JOURNAL OF NEUROSCIENCE}},
  keywords     = {{Pupil,Generalised arousal,Neuroscience,Turbulence,Functional data analysis,emotional motor control,functional data,generalised arousal,neuromodulation,singing,turbulence,LOCUS-COERULEUS,BASAL FOREBRAIN,NORADRENERGIC MODULATION,GENERALIZED AROUSAL,SYSTEM,MUSIC,BRAIN,DIAMETER,CORTEX,VOICE}},
  language     = {{eng}},
  location     = {{Frankfurt}},
  pages        = {{1--15}},
  title        = {{Cholinergic‐related pupil activity reflects level of emotionality during motor performance}},
  url          = {{http://doi.org/10.1111/ejn.15998}},
  year         = {{2023}},
}

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