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Comprehensive metabolomics reveals correlation between sophorolipid biosynthesis and autophagy

Sven Dierickx, Maximilien Souvereyns, Sophie Roelants (UGent) , Marilyn De Graeve (UGent) , Lieven Van Meulebroek (UGent) , Sofie De Maeseneire (UGent) , Wim Soetaert (UGent) and Lynn Vanhaecke (UGent)
(2023) NEW BIOTECHNOLOGY. 75. p.1-12
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Abstract
Sophorolipids are biobased and biodegradable glycolipid surface-active agents contributing to the shift from petroleum to biobased surfactants, associated with clear environmental benefits. However, their production cost is currently too high to allow commercialisation. Therefore, a continuous sophorolipid production process was evaluated, i.e., a retentostat with an external filtration unit. Despite an initial increase in volumetric productivity, productivity eventually declined to almost 0 g L-1 h-1. Following comprehensive metabolomics on supernatant obtained from a standardised retentostat, we hypothesised exhaustion of the N-starvation-induced autophagy as the main mechanism responsible for the decline in bolaform sophorolipid productivity. Thirty-six metabolites that correlate with RNA/protein autophagy and high sophorolipid productivity were putatively identified. In conclusion, our results unveil a plausible cause of this bola sophorolipid productivity decline in an industrially relevant bioreactor set-up, which may thus impact majorly on future yeast biosurfactant regulation studies and the finetuning of bola sophorolipid production processes.
Keywords
Starmerella bombicola, Sophorolipids, Metabolomics, Autophagy, Retentostat, ACID ETHYL-ESTERS, NITROGEN STARVATION, YEAST, ESTERIFICATION, SACCHAROMYCES, GLUTATHIONE, PLATFORM

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Citation

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MLA
Dierickx, Sven, et al. “Comprehensive Metabolomics Reveals Correlation between Sophorolipid Biosynthesis and Autophagy.” NEW BIOTECHNOLOGY, vol. 75, 2023, pp. 1–12, doi:10.1016/j.nbt.2023.02.002.
APA
Dierickx, S., Souvereyns, M., Roelants, S., De Graeve, M., Van Meulebroek, L., De Maeseneire, S., … Vanhaecke, L. (2023). Comprehensive metabolomics reveals correlation between sophorolipid biosynthesis and autophagy. NEW BIOTECHNOLOGY, 75, 1–12. https://doi.org/10.1016/j.nbt.2023.02.002
Chicago author-date
Dierickx, Sven, Maximilien Souvereyns, Sophie Roelants, Marilyn De Graeve, Lieven Van Meulebroek, Sofie De Maeseneire, Wim Soetaert, and Lynn Vanhaecke. 2023. “Comprehensive Metabolomics Reveals Correlation between Sophorolipid Biosynthesis and Autophagy.” NEW BIOTECHNOLOGY 75: 1–12. https://doi.org/10.1016/j.nbt.2023.02.002.
Chicago author-date (all authors)
Dierickx, Sven, Maximilien Souvereyns, Sophie Roelants, Marilyn De Graeve, Lieven Van Meulebroek, Sofie De Maeseneire, Wim Soetaert, and Lynn Vanhaecke. 2023. “Comprehensive Metabolomics Reveals Correlation between Sophorolipid Biosynthesis and Autophagy.” NEW BIOTECHNOLOGY 75: 1–12. doi:10.1016/j.nbt.2023.02.002.
Vancouver
1.
Dierickx S, Souvereyns M, Roelants S, De Graeve M, Van Meulebroek L, De Maeseneire S, et al. Comprehensive metabolomics reveals correlation between sophorolipid biosynthesis and autophagy. NEW BIOTECHNOLOGY. 2023;75:1–12.
IEEE
[1]
S. Dierickx et al., “Comprehensive metabolomics reveals correlation between sophorolipid biosynthesis and autophagy,” NEW BIOTECHNOLOGY, vol. 75, pp. 1–12, 2023.
@article{01H16YQSAB0E2PGXJS09JMB42T,
  abstract     = {{Sophorolipids are biobased and biodegradable glycolipid surface-active agents contributing to the shift from petroleum to biobased surfactants, associated with clear environmental benefits. However, their production cost is currently too high to allow commercialisation. Therefore, a continuous sophorolipid production process was evaluated, i.e., a retentostat with an external filtration unit. Despite an initial increase in volumetric productivity, productivity eventually declined to almost 0 g L-1 h-1. Following comprehensive metabolomics on supernatant obtained from a standardised retentostat, we hypothesised exhaustion of the N-starvation-induced autophagy as the main mechanism responsible for the decline in bolaform sophorolipid productivity. Thirty-six metabolites that correlate with RNA/protein autophagy and high sophorolipid productivity were putatively identified. In conclusion, our results unveil a plausible cause of this bola sophorolipid productivity decline in an industrially relevant bioreactor set-up, which may thus impact majorly on future yeast biosurfactant regulation studies and the finetuning of bola sophorolipid production processes.}},
  author       = {{Dierickx, Sven and Souvereyns, Maximilien and Roelants, Sophie and De Graeve, Marilyn and Van Meulebroek, Lieven and De Maeseneire, Sofie and Soetaert, Wim and Vanhaecke, Lynn}},
  issn         = {{1871-6784}},
  journal      = {{NEW BIOTECHNOLOGY}},
  keywords     = {{Starmerella bombicola,Sophorolipids,Metabolomics,Autophagy,Retentostat,ACID ETHYL-ESTERS,NITROGEN STARVATION,YEAST,ESTERIFICATION,SACCHAROMYCES,GLUTATHIONE,PLATFORM}},
  language     = {{eng}},
  pages        = {{1--12}},
  title        = {{Comprehensive metabolomics reveals correlation between sophorolipid biosynthesis and autophagy}},
  url          = {{http://doi.org/10.1016/j.nbt.2023.02.002}},
  volume       = {{75}},
  year         = {{2023}},
}
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