@inproceedings{01H114FJ0TA0811MP5C58SWAN3,
  abstract     = {{Objective To describe the long term outcomes and surgical complications of intestinal-type adenocarcinoma (ITAC), treated with endonasal endoscopic approach (EEA) r external surgery (ES), followed by adjuvant IMRT. Previously, we reported that EEA was feasible in T3-T4 tumors with a trend of improved survival (p=0.10). We provide an update of a retrospective cohort study a referral centre in Belgium, with an analysis of long term outcomes, surgical complications, and TME analysis with focus on tumor infiltrating lymphocytes (TILs). Material and methods A single-centre retrospective cohort study was performed on all patients diagnosed with ITAC between 1998 and 2018. Survival curves were obtained using Kaplan-Meier method and compared with the log-rank test. We used Fisher’s exact test to compare incidence of postoperative complications between surgical groups. Tumor-infiltrating lymphocytes were assessed following the IIBWG guidelines with hemathoxylin/eosin stain and CD3+ and CD8+ IHC (DAKO). Results 92 patients were treated with endonasal endoscopic approach (EEA, n=40) or external surgery (ES, n=52), followed by adjuvant IMRT. With a median follow-up of 16 years, median overall survival (OS), disease specific survival (DSS), local relapse free survival (LRFS) and disease free survival (DFS) were 8.1years [95%CI 6.0-11.1], 6.5years [95%CI 4.1-21.0], 9.1years [95%CI 4.1y-9.1y] and 6.9years [95%CI 3.5y-10.5y] respectively. DSS was significantly longer in the EEA cohort (HR 0.51, 95%CI 0.27-0.96) (see table 1). There was no statistically significant difference in surgical complications, but the duration of hospitalization was significantly shorter for EEA (median 4 days), compared to ES (median 8 days) (p=<0.001) (table 1). High CD3+ (4+; HR=0.26 [95% 0.07-0.96]; P = 0.0432) or CD8+ TIL count (2+ or higher; HR=0.11 [95%CI 0.02-0.58]; P = 0.0090) were associated with improved DSS (fig 1). Conclusions EEA is a feasible and safe surgical approach in ITAC, with good long term survival. Surgical complications are rare in reference centers, and duration of hospitalization is shorter for EEA compared to ES. High CD3+ and CD8+ TILs are associated with an improved prognosis, and merit further investigation.}},
  author       = {{Saerens, Michael and Vermassen, Tijl and De Keukeleire, Stijn and Debacker, Jens and Duprez, Fréderic and Deron, Philippe and Huvenne, Wouter and Creytens, David and Rottey, Sylvie and Van Zele, Thibaut}},
  booktitle    = {{10th European Congress on Head & Neck Oncology, Abstracts}},
  language     = {{eng}},
  location     = {{Lisbon, Portugal}},
  title        = {{Long-term outcomes and surgical complications of endonasal endoscopic surgery in ITAC}},
  year         = {{2023}},
}