@inproceedings{01GZXWCB452VVC1NBCDM43XRSF,
  abstract     = {{The wide application of antibiotics has brought threats to freshwater ecosystems. Besides direct adverse effects on non-target aquatic organisms, the residues of persistent antibiotics in surface water enhances the selection pressure of antibiotic resistance (ABR) genes, too. The Safe and Sustainable by Design (SSbD) concept promotes sustainable pharmaceuticals that have lower potential hazardous impact on the environment throughout their life cycle: production, emission, degradation, and mitigation. An alternative compound derived from ciprofloxacin (CIP), CIP-Hemi, was developed based on the SSbD concept. Being higher in degradability than CIP, the chemical is likely to be less persistent in the environment. This study compared the ecotoxicity of CIP-Hemi and CIP using a cyanobacteria growth inhibition test. A species sensitive to CIP, Microcystis aeruginosa PCC 7806 was employed. As both CIP and CIP-Hemi are ionizable compounds, the test was performed at pH 8.0, at which the highest ecotoxicity of CIP is expected. Test results show that the observed ecotoxicity of CIP-Hemi, described by the 50% effect concentration (EC50), is at least 1 magnitude lower than that of CIP. Hence, CIP-Hemi is a promising compound that might result in reduced ecological risk to aquatic ecosystem.}},
  articleno    = {{P-Mo409}},
  author       = {{Zhang, Qiyun and De Schamphelaere, Karel}},
  booktitle    = {{SETAC Europe, 33rd Annual Meeting, Abstracts}},
  issn         = {{2309-8031}},
  language     = {{eng}},
  location     = {{Dublin, Ireland & online}},
  pages        = {{P-Mo409:840--P-Mo409:840}},
  title        = {{Sustainable by design : an aquatic ecosystem friendlier alternative for ciprofloxacin}},
  year         = {{2023}},
}