Influence of the size and charge of carbon quantum dots on their corneal penetration and permeation enhancing properties
- Author
- Inès De Hoon (UGent) , Alexandre Barras, Tomasz Swebocki, Bernd Vanmeerhaeghe (UGent) , Bram Bogaert (UGent) , Cristina Muntean (UGent) , Amar Abderrahmani, Rabah Boukherroub, Stefaan De Smedt (UGent) , Félix Sauvage (UGent) and Sabine Szunerits
- Organization
- Project
- Abstract
- Reaching the corneal endothelium through the topical admin-istration of therapeutic drugs remains a challenge in ophthalmology. Besides, endothelial cells are not able to regenerate, and diseases at this site can lead to corneal blindness. Targeting the corneal endothelium implies efficient penetration through the three corneal layers, which still remains difficult for small molecules. Carbon quantum dots (CQDs) have demonstrated great potential for ocular nanomedicine. This study focuses on the corneal penetration abilities of differently charged CQDs and their use as permeation enhancers for drugs. Excised whole bovine eyes were used as an ex vivo model to investigate corneal penetration of CQDs derived from glucosamine using beta-alanine, ethylenediamine, or spermidine as a passivation agent. It was found that negatively charged CQDs have limited corneal penetration ability, while positively charged CQDs derived from glucosamine hydrochloride and spermidine (CQD-S) penetrate the entire corneal epithelium all the way down to the endothelium. CQD-S were shown to enhance the penetration of FITC-dextran 150 kDa, suggesting that they could be used as efficient penetration enhancers for therapeutic delivery to the corneal endothelium.
- Keywords
- cornea, epithelium, endothelium, carbon quantum dots, fluorescence spectroscopy, DRUG-DELIVERY
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GZEAR4CJ2HFH0F6DDDYENZ80
- MLA
- De Hoon, Inès, et al. “Influence of the Size and Charge of Carbon Quantum Dots on Their Corneal Penetration and Permeation Enhancing Properties.” ACS APPLIED MATERIALS & INTERFACES, vol. 15, no. 3, 2023, pp. 3760–71, doi:10.1021/acsami.2c18598.
- APA
- De Hoon, I., Barras, A., Swebocki, T., Vanmeerhaeghe, B., Bogaert, B., Muntean, C., … Szunerits, S. (2023). Influence of the size and charge of carbon quantum dots on their corneal penetration and permeation enhancing properties. ACS APPLIED MATERIALS & INTERFACES, 15(3), 3760–3771. https://doi.org/10.1021/acsami.2c18598
- Chicago author-date
- De Hoon, Inès, Alexandre Barras, Tomasz Swebocki, Bernd Vanmeerhaeghe, Bram Bogaert, Cristina Muntean, Amar Abderrahmani, et al. 2023. “Influence of the Size and Charge of Carbon Quantum Dots on Their Corneal Penetration and Permeation Enhancing Properties.” ACS APPLIED MATERIALS & INTERFACES 15 (3): 3760–71. https://doi.org/10.1021/acsami.2c18598.
- Chicago author-date (all authors)
- De Hoon, Inès, Alexandre Barras, Tomasz Swebocki, Bernd Vanmeerhaeghe, Bram Bogaert, Cristina Muntean, Amar Abderrahmani, Rabah Boukherroub, Stefaan De Smedt, Félix Sauvage, and Sabine Szunerits. 2023. “Influence of the Size and Charge of Carbon Quantum Dots on Their Corneal Penetration and Permeation Enhancing Properties.” ACS APPLIED MATERIALS & INTERFACES 15 (3): 3760–3771. doi:10.1021/acsami.2c18598.
- Vancouver
- 1.De Hoon I, Barras A, Swebocki T, Vanmeerhaeghe B, Bogaert B, Muntean C, et al. Influence of the size and charge of carbon quantum dots on their corneal penetration and permeation enhancing properties. ACS APPLIED MATERIALS & INTERFACES. 2023;15(3):3760–71.
- IEEE
- [1]I. De Hoon et al., “Influence of the size and charge of carbon quantum dots on their corneal penetration and permeation enhancing properties,” ACS APPLIED MATERIALS & INTERFACES, vol. 15, no. 3, pp. 3760–3771, 2023.
@article{01GZEAR4CJ2HFH0F6DDDYENZ80,
abstract = {{Reaching the corneal endothelium through the topical admin-istration of therapeutic drugs remains a challenge in ophthalmology. Besides, endothelial cells are not able to regenerate, and diseases at this site can lead to corneal blindness. Targeting the corneal endothelium implies efficient penetration through the three corneal layers, which still remains difficult for small molecules. Carbon quantum dots (CQDs) have demonstrated great potential for ocular nanomedicine. This study focuses on the corneal penetration abilities of differently charged CQDs and their use as permeation enhancers for drugs. Excised whole bovine eyes were used as an ex vivo model to investigate corneal penetration of CQDs derived from glucosamine using beta-alanine, ethylenediamine, or spermidine as a passivation agent. It was found that negatively charged CQDs have limited corneal penetration ability, while positively charged CQDs derived from glucosamine hydrochloride and spermidine (CQD-S) penetrate the entire corneal epithelium all the way down to the endothelium. CQD-S were shown to enhance the penetration of FITC-dextran 150 kDa, suggesting that they could be used as efficient penetration enhancers for therapeutic delivery to the corneal endothelium.}},
author = {{De Hoon, Inès and Barras, Alexandre and Swebocki, Tomasz and Vanmeerhaeghe, Bernd and Bogaert, Bram and Muntean, Cristina and Abderrahmani, Amar and Boukherroub, Rabah and De Smedt, Stefaan and Sauvage, Félix and Szunerits, Sabine}},
issn = {{1944-8244}},
journal = {{ACS APPLIED MATERIALS & INTERFACES}},
keywords = {{cornea,epithelium,endothelium,carbon quantum dots,fluorescence spectroscopy,DRUG-DELIVERY}},
language = {{eng}},
number = {{3}},
pages = {{3760--3771}},
title = {{Influence of the size and charge of carbon quantum dots on their corneal penetration and permeation enhancing properties}},
url = {{http://doi.org/10.1021/acsami.2c18598}},
volume = {{15}},
year = {{2023}},
}
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