@article{01GYA2TWGPX67HJRB01DWRK8SJ,
  abstract     = {{The gut microbiota represents a diverse and dynamic population of microorganisms that can influence the health of the host. Increasing evidence supports the role of the gut microbiota as a key player in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Unfortunately, the mechanisms behind the interplay between gut pathogens and AD are still elusive. It is known that bacteria-derived outer membrane vesicles (OMVs) act as natural carriers of virulence factors that are central players in the pathogenesis of the bacteria. Helicobacter pylori (H. pylori) is a common gastric pathogen and H. pylori infection has been associated with an increased risk to develop AD. Here, we are the first to shed light on the role of OMVs derived from H. pylori on the brain in healthy conditions and on disease pathology in the case of AD. Our results reveal that H. pylori OMVs can cross the biological barriers, eventually reaching the brain. Once in the brain, these OMVs are taken up by astrocytes, which induce activation of glial cells and neuronal dysfunction, ultimately leading to exacerbated amyloid-beta pathology and cognitive decline. Mechanistically, we identified a critical role for the complement component 3 (C3)-C3a receptor (C3aR) signalling in mediating the interaction between astrocytes, microglia and neurons upon the presence of gut H. pylori OMVs. Taken together, our study reveals that H. pylori has a detrimental effect on brain functionality and accelerates AD development via OMVs and C3-C3aR signalling.}},
  articleno    = {{e12306}},
  author       = {{Xie, Junhua and Cools, Lien and Van Imschoot, Griet and Van Wonterghem, Elien and Pauwels, Marie and  Vlaeminck, Ine and De Witte, Chloë and  EL Andaloussi, Samir and  Wierda, Keimpe and  De Groef, Lies and Haesebrouck, Freddy and Van Hoecke, Lien and Vandenbroucke, Roosmarijn}},
  issn         = {{2001-3078}},
  journal      = {{JOURNAL OF EXTRACELLULAR VESICLES}},
  keywords     = {{MOUSE MODELS,MICROGLIA,ASTROCYTES,EXPRESSION,STOMACH,BARRIER,CROSS,BETA,AXIS,Alzheimer's disease,gut-brain axis,Helicobacter pylori,bacterial extracellular vesicles (bEVs),outer membrane vesicles (OMVs),C3,complement}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{21}},
  title        = {{Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling}},
  url          = {{http://doi.org/10.1002/jev2.12306}},
  volume       = {{12}},
  year         = {{2023}},
}

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