@article{01GY7JJXBA400KVSSP8Z3V5X17,
  abstract     = {{Objective : The zebrafish is increasingly used as a small animal model for cardiovascular disease, including vascular disorders. Nevertheless, a comprehensive biomechanical understanding of the zebrafish cardiovascular circulation is still lacking and possibilities for phenotyping the zebrafish heart and vasculature at adult – no longer optically transparent – stages are limited. To improve these aspects, we developed imaging-based 3D models of the cardiovascular system of wild-type adult zebrafish. Methods: In vivo high-frequency echocardiography and ex vivo synchrotron x-ray tomography were combined to build fluid-structure interaction finite element models of the fluid dynamics and biomechanics inside the ventral aorta. Results: We successfully generated a reference model of the circulation in adult zebrafish. The dorsal side of the most proximal branching region was found as the location of highest first principal wall stress and was also a location of low wall shear stress. Reynolds number and oscillatory shear were very low compared to mice and humans. Significance: The presented wild-type results provide a first extensive biomechanical reference for adult zebrafish. This framework can be used for advanced cardiovascular phenotyping of adult genetically engineered zebrafish models of cardiovascular disease, showing disruptions of the normal mechano-biology and homeostasis. By providing reference values for key biomechanical stimuli (including wall shear stress and first principal stress) in wild-type animals, and a pipeline for image-based animal-specific computational biomechanical models, this study contributes to a more comprehensive understanding of the role of altered biomechanics and hemodynamics in heritable cardiovascular pathologies.}},
  author       = {{Van Impe, Matthias and Caboor, Lisa and Deleeuw, Violette and Olbinado, Margie and De Backer, Julie and Sips, Patrick and Segers, Patrick}},
  issn         = {{0018-9294}},
  journal      = {{IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING}},
  keywords     = {{Biomedical Engineering,fluid-structure interaction modeling,Adult zebrafish,animal model for cardiovascular disease,aortic hemodynamics,wall shear stress,synchrotron X-ray tomography}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{2101--2110}},
  title        = {{Fluid-structure interaction modeling of the aortic hemodynamics in adult zebrafish : a pilot study based on synchrotron x-ray tomography}},
  url          = {{http://doi.org/10.1109/tbme.2023.3236488}},
  volume       = {{70}},
  year         = {{2023}},
}

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