Human papillomavirus prevalence and breast carcinogenesis : a systematic review and meta-analysis of published literature
- Author
- Kasper Favere (UGent) , Sonia Menon (UGent) , Kristi Valentine (UGent) , J. Bogers and Davy Vanden Broeck (UGent)
- Organization
- Abstract
- Purpose investigation: The association between human papillomavirus (HPV) infection and breast cancer remains inconclusive as detection rates of high-risk HPV in breast cancer samples are extremely variable. A meta-analysis was conducted to determine the prevalence of HPV in breast neoplasms, with emphasis on genotype distribution. Materials and Methods: A systematic literature search of MEDLINE, The Cochrane Library, and ISI Web of Science databases was conducted, ending in August 2016. A meta-analysis was performed applying the random-effects model. Sub-analyses allowed to estimate the impact of different variables on the pooled prevalence. Results: Forty studies, representing 4762 breast cancer cases, were included. The pooled prevalence of HPV in breast cancer tissue was 20% (95% confidence interval (CA) [12%;29%]). HPV prevalence in breast neoplasms varied by publication period, continental region, HPV primer design, and HPV oncogenic features. Continental region of origin determined the prevailing genotype. Conclusion: The high prevalence of HPV in breast cancer supports the hypothesis that HPV infection is involved in breast carcinogenesis.
- Keywords
- Breast neoplasms, Review, Meta-analysis, Epidemiology, Etiology, Papillomaviridae, EPSTEIN-BARR-VIRUS, NO EVIDENCE, DNA-SEQUENCES, HPV INFECTION, CANCER, PATIENTS, SYRIAN WOMEN, ASSOCIATION, RISK, CARCINOMA, IDENTIFICATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GXRJCTPKXVP576ZP9QE2V9S4
- MLA
- Favere, Kasper, et al. “Human Papillomavirus Prevalence and Breast Carcinogenesis : A Systematic Review and Meta-Analysis of Published Literature.” EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, vol. 39, no. 2, IMR Press, 2018, pp. 161–73, doi:10.12892/ejgo4068.2018.
- APA
- Favere, K., Menon, S., Valentine, K., Bogers, J., & Vanden Broeck, D. (2018). Human papillomavirus prevalence and breast carcinogenesis : a systematic review and meta-analysis of published literature. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 39(2), 161–173. https://doi.org/10.12892/ejgo4068.2018
- Chicago author-date
- Favere, Kasper, Sonia Menon, Kristi Valentine, J. Bogers, and Davy Vanden Broeck. 2018. “Human Papillomavirus Prevalence and Breast Carcinogenesis : A Systematic Review and Meta-Analysis of Published Literature.” EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY 39 (2): 161–73. https://doi.org/10.12892/ejgo4068.2018.
- Chicago author-date (all authors)
- Favere, Kasper, Sonia Menon, Kristi Valentine, J. Bogers, and Davy Vanden Broeck. 2018. “Human Papillomavirus Prevalence and Breast Carcinogenesis : A Systematic Review and Meta-Analysis of Published Literature.” EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY 39 (2): 161–173. doi:10.12892/ejgo4068.2018.
- Vancouver
- 1.Favere K, Menon S, Valentine K, Bogers J, Vanden Broeck D. Human papillomavirus prevalence and breast carcinogenesis : a systematic review and meta-analysis of published literature. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY. 2018;39(2):161–73.
- IEEE
- [1]K. Favere, S. Menon, K. Valentine, J. Bogers, and D. Vanden Broeck, “Human papillomavirus prevalence and breast carcinogenesis : a systematic review and meta-analysis of published literature,” EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, vol. 39, no. 2, pp. 161–173, 2018.
@article{01GXRJCTPKXVP576ZP9QE2V9S4,
abstract = {{Purpose investigation: The association between human papillomavirus (HPV) infection and breast cancer remains inconclusive as detection rates of high-risk HPV in breast cancer samples are extremely variable. A meta-analysis was conducted to determine the prevalence of HPV in breast neoplasms, with emphasis on genotype distribution. Materials and Methods: A systematic literature search of MEDLINE, The Cochrane Library, and ISI Web of Science databases was conducted, ending in August 2016. A meta-analysis was performed applying the random-effects model. Sub-analyses allowed to estimate the impact of different variables on the pooled prevalence. Results: Forty studies, representing 4762 breast cancer cases, were included. The pooled prevalence of HPV in breast cancer tissue was 20% (95% confidence interval (CA) [12%;29%]). HPV prevalence in breast neoplasms varied by publication period, continental region, HPV primer design, and HPV oncogenic features. Continental region of origin determined the prevailing genotype. Conclusion: The high prevalence of HPV in breast cancer supports the hypothesis that HPV infection is involved in breast carcinogenesis.}},
author = {{Favere, Kasper and Menon, Sonia and Valentine, Kristi and Bogers, J. and Vanden Broeck, Davy}},
issn = {{0392-2936}},
journal = {{EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY}},
keywords = {{Breast neoplasms,Review,Meta-analysis,Epidemiology,Etiology,Papillomaviridae,EPSTEIN-BARR-VIRUS,NO EVIDENCE,DNA-SEQUENCES,HPV INFECTION,CANCER,PATIENTS,SYRIAN WOMEN,ASSOCIATION,RISK,CARCINOMA,IDENTIFICATION}},
language = {{eng}},
number = {{2}},
pages = {{161--173}},
publisher = {{IMR Press}},
title = {{Human papillomavirus prevalence and breast carcinogenesis : a systematic review and meta-analysis of published literature}},
url = {{http://doi.org/10.12892/ejgo4068.2018}},
volume = {{39}},
year = {{2018}},
}
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