@article{01GXGE1ET66JBXRHMMJTMQVXBX,
  abstract     = {{BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.}},
  articleno    = {{22}},
  author       = {{Matuozzo, Daniela and Talouarn, Estelle and Marchal, Astrid and Zhang, Peng and Manry, Jeremy and Seeleuthner, Yoann and Zhang, Yu and Bolze, Alexandre and Chaldebas, Matthieu and Milisavljevic, Baptiste and Gervais, Adrian and Bastard, Paul and Asano, Takaki and Bizien, Lucy and Barzaghi, Federica and Abolhassani, Hassan and Abou Tayoun, Ahmad and Aiuti, Alessandro and Alavi Darazam, Ilad and Allende, Luis M. and Alonso-Arias, Rebeca and Arias, Andrés Augusto and Aytekin, Gokhan and Bergman, Peter and Bondesan, Simone and Bryceson, Yenan T. and Bustos, Ingrid G. and Cabrera-Marante, Oscar and Carcel, Sheila and Carrera, Paola and Casari, Giorgio and Chaïbi, Khalil and Colobran, Roger and Condino-Neto, Antonio and Covill, Laura E. and Delmonte, Ottavia M. and El Zein, Loubna and Flores, Carlos and Gregersen, Peter K. and Gut, Marta and Haerynck, Filomeen and Halwani, Rabih and Hancerli, Selda and Hammarström, Lennart and Hatipoğlu, Nevin and Karbuz, Adem and Keles, Sevgi and Kyheng, Christèle and Leon-Lopez, Rafael and Franco, Jose Luis and Mansouri, Davood and Martinez-Picado, Javier and Metin Akcan, Ozge and Migeotte, Isabelle and Morange, Pierre-Emmanuel and Morelle, Guillaume and Martin-Nalda, Andrea and Novelli, Giuseppe and Novelli, Antonio and Ozcelik, Tayfun and Palabiyik, Figen and Pan-Hammarström, Qiang and de Diego, Rebeca Pérez and Planas-Serra, Laura and Pleguezuelo, Daniel E. and Prando, Carolina and Pujol, Aurora and Reyes, Luis Felipe and Rivière, Jacques G. and Rodriguez-Gallego, Carlos and Rojas, Julian and Rovere-Querini, Patrizia and Schlüter, Agatha and Shahrooei, Mohammad and Sobh, Ali and Soler-Palacin, Pere and Tandjaoui-Lambiotte, Yacine and Tipu, Imran and Tresoldi, Cristina and Troya, Jesus and van de Beek, Diederik and Zatz, Mayana and Zawadzki, Pawel and Al-Muhsen, Saleh Zaid and Alosaimi, Mohammed Faraj and Alsohime, Fahad M. and Baris-Feldman, Hagit and Butte, Manish J. and Constantinescu, Stefan N. and Cooper, Megan A. and Dalgard, Clifton L. and Fellay, Jacques and Heath, James R. and Lau, Yu-Lung and Lifton, Richard P. and Maniatis, Tom and Mogensen, Trine H. and von Bernuth, Horst and Lermine, Alban and Vidaud, Michel and Boland, Anne and Deleuze, Jean-François and Nussbaum, Robert and Kahn-Kirby, Amanda and Mentre, France and Tubiana, Sarah and Gorochov, Guy and Tubach, Florence and Hausfater, Pierre and Abel, Laurent and Al-Muhsen, Saleh and Al-Mulla, Fahd and Anderson, Mark S. and Andreakos, Evangelos and Arias, Andrés A. and Feldman, Hagit Baris and Belot, Alexandre and Biggs, Catherine M. and Bogunovic, Dusan and Bondarenko, Anastasiia and Bousfiha, Ahmed A. and Brodin, Petter and Bryceson, Yenan and Bustamante, Carlos D. and Chakravorty, Samya and Christodoulou, John and Desai, Murkesh and Drolet, Beth A. and Baghdadi, Jamila El and Espinosa-Padilla, Sara and Franco, José Luis and Froidure, Antoine and Hagin, David and Henrickson, Sarah E. and Hsieh, Elena W. Y. and Husebye, Eystein and Imai, Kohsuke and Itan, Yuval and Jarvis, Erich D. and Karamitros, Timokratis and Kisand, Kai and Ku, Cheng-Lung and Ling, Yun and Lucas, Carrie L. and Maródi, László and Meyts, Isabelle and Milner, Joshua D. and Mironska, Kristina and Morio, Tomohiro and Ng, Lisa F. P. and Notarangelo, Luigi D. and O’Farrelly, Cliona and Okada, Satoshi and Planas, Anna M. and Quintana-Murci, Lluis and Renia, Laurent and Resnick, Igor and Rodríguez-Gallego, Carlos and Sancho-Shimizu, Vanessa and Sediva, Anna and Seppänen, Mikko R. J. and Shcherbina, Anna and Slaby, Ondrej and Snow, Andrew L. and Soler-Palacín, Pere and Spaan, András N. and Tancevski, Ivan and Tangye, Stuart G. and Ramaswamy, Sathishkumar and Turvey, Stuart E. and Uddin, Furkan and Uddin, Mohammed J. and van de Beek, Diederik and Vinh, Donald C. and Zatz, Mayana and Su, Helen C. and Casanova, Jean-Laurent and Bureau, Serge and Vacher, Yannick and Gysembergh-Houal, Anne and Demerville, Lauren and Chachoua, Abla and Abad, Sebastien and Abassi, Radhiya and Abdellaoui, Abdelrafie and Abdelmalek, Abdelkrim and Abdoul, Hendy and Abergel, Helene and Abeud, Fariza and Abgrall, Sophie and Abisror, Noemie and Adechian, Marylise and Aderdour, Nordine and Admane, Hakeem Farid and Adnet, Frederic and Afritt, Sara and Agostini, Helene and Aguilar, Claire and Agut, Sophie and Aiello, Tommaso Francesco and Kaci, Marc Ait and Oufella, Hafid Ait and Ajeenthiravasan, Gokula and Alauzy, Virginie and Alby-Laurent, Fanny and Allard, Lucie and Alyanakian, Marie-Alexandra and Borrero, Blanca Amador and Amam, Sabrina and Amrouche, Lucile and Andronikof, Marc and Anglicheau, Dany and Anguel, Nadia and Annane, Djillali and Aounzou, Mohammed and Aparicio, Caroline and Aratus, Gladys and Arlet, Jean-Benoit and Arzoine, Jeremy and Aslangul, Elisabeth and Assefi, Mona and Aubry, Adeline and Audiffred, Laetitia and Audureau, Etienne and Auger, Christelle Nathalie and Auregan, Jean-Charles and Awotar, Celine and Milla, Sonia Ayllon and Azan, Delphine and Azemar, Laurene and Azzouguen, Billal and Elrufaai, Marwa Bachir and Badsi, Aïda and Bakouboula, Prissile and Balcerowiak, Coline and Balde, Fanta and Baldivia, Elodie and Bangamingo, Eliane-Flore and Baptiste, Amandine and Baran-Marszak, Fanny and Barau, Caroline and Barget, Nathalie and Baronnet, Flore and Barthelemy, Romain and Baudel, Jean-Luc and Baudry, Camille and Baudry, Elodie and Beaugerie, Laurent and Belamri, Adel and Belaube, Nicolas and Belilita, Rhida and Bellassen, Pierre and Belmokhtar, Rawan and Beltran, Isabel and Benainous, Ruben and Benallaoua, Mourad and Benamouzig, Robert and Benbara, Amélie and Benhida, Jaouad and Benkhelouf, Anis and Benlagha, Jihene and Benmostafa, Chahinez and Benothmane, Skander and Bentifraouine, Miassa and Berard, Laurence and Bernier, Quentin and Berti, Enora and Bertier, Astrid and Berton, Laure and Bessis, Simon and Beurton, Alexandra and Bianco, Celine and Bianquis, Clara and Bidar, Frank and Blanche, Philippe and Blayau, Clarisse and Bleibtreu, Alexandre and Blin, Emmanuelle and Bloch-Queyrat, Coralie and Boissier, Marie-Christophe and Bollens, Diane and Bolzoni, Marion and Bompard, Rudy pierre and Bonnet, Nicolas and Bonnouvrier, Justine and Botha, Shirmonecrystal and Boucenna, Wissam and Bouchama, Fatiha and Bouchaud, Olivier and Bouchghoul, Hanane and Boudjebla, Taoueslylia and Boudjema, Noel and Bouffard, Catherine and Bougle, Adrien and Bouguerra, Meriem and Bouras, Leila and Bourcier, Agnes and Durand, Anne Bourgarit and Bourrier, Anne and Bouscarat, Fabrice and Bouvry, Diane and Bouziri, Nesrine and Bouzrara, Ons and Bribier, Sarah and Brugier, Delphine and Brunel, Melanie and Bui, Eida and Buisson, Anne and Bukreyeva, Iryna and Bureau, Côme and Cadranel, Jacques and Cailhol, Johann and Calin, Ruxandra and Vega, Clara Campos and Canavaggio, Pauline and Cancella, Marta and Cantin, Delphine and Cao, Albert and Carbillon, Lionel and Carlier, Nicolas and Cassard, Clementine and Castor, Guylaine and Cauchy, Marion and Cha, Olivier and Chaigne, Benjamin and Challal, Salima and Champion, Karine and Chariot, Patrick and Chas, Julie and Chauveau, Simon and Chauvin, Anthony and Chauvin, Clement and Chavarot, Nathalie and Chebbout, Kamélia and Cherai, Mustapha and Cherubini, Ilaria and Chevalier, Amelie and Chiarabini, Thibault and Chinet, Thierry and Chocron, Richard and Choinier, Pascaline and Chommeloux, Juliette and Choquet, Christophe and Choupeaux, Laure and Chousterman, Benjamin and Ciocan, Dragosmarius and Clarke, Ada and Clavere, Gaëlle and Clavier, Florian and Clement, Karine and Clerc, Sebastien and Cohen, Yves and Cohen, Fleur and Cohen, Adrien and Coilly, Audrey and Colboc, Hester and Colin, Pauline and Collet, Magalie and Comarmond, Chloé and Combacon, Emeline and Combes, Alain and Comparon, Celine and Constantin, Jean-Michel and Cordel, Hugues and Cordier, Anne-Gael and Costantini, Adrien and Chalumeau, Nathalie Costedoat and Couffignal, Camille and Coupeau, Doriane and Creange, Alain and Lamarre, Yannie Cuvillier and Da Silveira, Charlène and Kayani, Sandrine Dautheville Guibal El and De Castro, Nathalie and De Rycke, Yann and Del Pozo, Lucie and Delannoy, Quentin and Delay, Mathieu and Deleris, Robin and Delforge, Juliette and Delphine, Laëtitia and Demare, Noemie and Demeret, Sophie and Demoule, Alexandre and Deniau, Aurore and Depret, François and Derolez, Sophie and Derradji, Ouda and Derridj, Nawal and Descamps, Vincent and Deschamps, Lydia and Desconclois, Celine and Desnos, Cyrielle and Desongins, Karine and Dhote, Robin and Diallo, Benjamin and Didier, Morgane and Diemer, Myriam and Diez, Stephane and Djadi-Prat, Juliette and Monnory, Fatima-Zohra Djamouri and Djebara, Siham and Djebra, Naoual and Djietcheu, Minette and Djillali, Hadjer and Djouadi, Nouara and Donneger, Severine and Dos Santos, Catarina and Dournon, Nathalie and Dres, Martin and Droctove, Laura and Drogrey, Marie and Dropy, Margot and Drouet, Elodie and Dubosq, Valérie and Dubreucq, Evelyne and Dubus, Estelle and Duchemann, Boris and Duchenoy, Thibault and Dudoignon, Emmanuel and Dufau, Romain and Dumas, Florence and Duran, Clara and Duron, Emmanuelle and Durrbach, Antoine and Duvivier, Claudine and Ebstein, Nathan and Khalifa, Jihane El and Elabbadi, Alexandre and Elie, Caroline and Ernotte, Gabriel and Esling, Anne and Etienne, Martin and Eyer, Xavier and Fartoukh, Muriel sarah and Fayali, Takoua and Fermaut, Marion and Fiorentino, Arianna and Fliss, Souha and 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Martin and Silvain, Johanne and Simon, Noémie and Simon, Tabassome and Skandri, Lina Innes and Slimani, Miassa and Snauwaert, Aurélie and Sokol, Harry and Soliman, Heithem and Soltani, Nisrine and Soyer, Benjamin and Steg, Gabriel and Suarez, Lydia and Szwebel, Tali-Anne and Taffame, Kossi and Tantet, Claire and Tateo, Mariagrazia and Theodose, Igor and Thiebaud, Pierre clement and Thomas, Caroline and Tiercelet, Kelly and Tisserand, Julie and Tomczak, Carole and Torelino, Krystel and Touam-Ext, Fatima and Toumi, Lilia and Toury, Gustave and Toy-Miou, Mireille and Lien, Olivia Tran Dinh Thanh and Trandinh, Alexy and Treluyer, Jean-Marc and Trinque, Baptiste and Truchot, Jennifer and Tunesi, Simone and Turpin, Matthieu and Turpin, Agathe and Urbina, Tomas and Narvaez, Rafael Usubillaga and Uzunhan, Yurdagul and Vaittinadaayar, Prabakar and Valent, Arnaud and Valentian, Maelle and Valin, Nadia and Vallet, Hélène and Vaz, Marina and Vazquezibarra, Miguel-Alejandro and Vedie, Benoit and Velly, Laetitia and Verstuyft, Celine and Viallette, Cedric and Vicaut, Eric and Vignes, Dorothee and Vimpere, Damien and Virlouvet, Myriam and Voiriot, Guillaume and Voisot, Lena and Weiss, Emmanuel and Weiss, Nicolas and Winchenne, Anaïs and Yordanov, Youri and Zafrani, Lara and Zaidan, Mohamad and Zaidi, Wissem and Zak, Cathia and Zarhrate-Ghoul, Aida and Zatout, Ouassila and Zeino, Suzanne and Zeitouni, Michel and Zemirli, Naïma and Zerah, Lorene and Zia, Ounsa and Ziol, Marianne and Zolario, Oceane and Zuber, Julien and Abel, Laurent and Andrejak, Claire and Angoulvant, François and Bachelet, Delphine and Bartoli, Marie and Basmaci, Romain and Behilill, Sylvie and Beluze, Marine and Benkerrou, Dehbia and Bhavsar, Krishna and Bouadma, Lila and Bouchez, Sabelline and Bouscambert, Maude and Cervantes-Gonzalez, Minerva and Chair, Anissa and Chirouze, Catherine and Coelho, Alexandra and Couffignal, Camille and Couffin-Cadiergues, Sandrine and d’Ortenzio, Eric and Debray, Marie-Pierre and Deconinck, Lauren and Deplanque, Dominique and Descamps, Diane and Desvallée, Mathilde and Diallo, Alpha and Diouf, Alphonsine and Dorival, Céline and Dubos, François and Duval, Xavier and Elharrar, Brigitte and Eloy, Philippine and Enouf, Vincent and Esperou, Hélène and Esposito-Farese, Marina and Etienne, Manuel and Devouge, Eglantine Ferrand and Gault, Nathalie and Gaymard, Alexandre and Ghosn, Jade and Gigante, Tristan and Gilg, Morgane and Guedj, Jérémie and Hoctin, Alexandre and Hoffmann, Isabelle and Houas, Ikram and Hulot, Jean-Sébastien and Jaafoura, Salma and Kafif, Ouifiya and Kaguelidou, Florentia and Kali, Sabrina and Khalil, Antoine and Khan, Coralie and Laouénan, Cédric and Laribi, Samira and Le, Minh and Le Hingrat, Quentin and Le Mestre, Soizic and Le Nagard, Hervé and Lescure, François-Xavier and Letrou, Sophie and Levy, Yves and Lina, Bruno and Lingas, Guillaume and Lucet, Jean Christophe and Malvy, Denis and Mambert, Marina and Mentré, France and Meziane, Amina and Mouquet, Hugo and Mullaert, Jimmy and Neant, Nadège and Nguyen, Duc and Noret, Marion and Nseir, Saad and Papadopoulos, Aurélie and Paul, Christelle and Peiffer-Smadja, Nathan and Perpoint, Thomas and Petrov-Sanchez, Ventzislava and Peytavin, Gilles and Pham, Huong and Picone, Olivier and Piquard, Valentine and Puéchal, Oriane and Rabaud, Christian and Rosa-Calatrava, Manuel and Rossignol, Bénédicte and Rossignol, Patrick and Roy, Carine and Schneider, Marion and Su, Richa and Tardivon, Coralie and Tellier, Marie-Capucine and Téoulé, François and Terrier, Olivier and Timsit, Jean-François and Tual, Christelle and Van Der Werf, Sylvie and Vanel, Noémie and Veislinger, Aurélie and Visseaux, Benoit and Wiedemann, Aurélie and Yazdanpanah, Yazdan and Alavoine, Loubna and Behillil, Sylvie and Burdet, Charles and Charpentier, Charlotte and Dechanet, Aline and Descamps, Diane and Duval, Xavier and Ecobichon, Jean-Luc and Enouf, Vincent and Frezouls, Wahiba and Houhou, Nadhira and Kafif, 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C. and Fusco, Francesca and Gagro, Alenka and Solis, Blanca Garcia and Garçon, Pierre and Gaussem, Pascale and Gayretli, Zeynep and Gil-Herrera, Juana and Gilardin, Laurent and Gatineau, Audrey Giraud and Girona-Alarcón, Mònica and Godínez, Karen Alejandra Cifuentes and Goffard, Jean-Christophe and Gonzales, Nacho and Gonzalez-Granado, Luis I. and González-Montelongo, Rafaela and Guerder, Antoine and Gülhan, Belgin and Gumucio, Victor Daniel and Hanitsch, Leif Gunnar and Gunst, Jan and Hadjadj, Jérôme and Hariyan, Tetyana and Hatipoglu, Nevin and Heppekcan, Deniz and Hernandez-Brito, Elisa and Ho, Po-ki and Holanda-Peña, María Soledad and Horcajada, Juan P. and Hraiech, Sami and Humbert, Linda and Hung, Ivan F. N. and Iglesias, Alejandro D. and Íñigo-Campos, Antonio and Jamme, Matthieu and Arranz, María Jesús and Jimeno, Marie-Thérèse and Jordan, Iolanda and Yüksek, Saliha Kanık and Kara, Yalcin Burak and Karahan, Aydın and Yasar, Kadriye Kart and Kasapcopur, Ozgur and Kashimada, Kenichi and Demirkol, Yasemin Kendir and Kido, Yasutoshi and Kizil, Can and Kılıç, Ahmet Osman and Klocperk, Adam and Koutsoukou, Antonia and Król, Zbigniew J. and Ksouri, Hatem and Kuentz, Paul and Kwan, Arthur M. C. and Kwan, Yat Wah M. and Kwok, Janette S. Y. and Lagier, Jean-Christophe and Lam, David S. Y. and Lampropoulou, Vicky and Lanternier, Fanny and Le Bourgeois, Fleur and Leo, Yee-Sin and Lopez, Rafael Leon and Leung, Daniel and Levin, Michael and Levy, Michael and Lévy, Romain and Li, Zhi and Lilleri, Daniele and Lima, Edson Jose Adrian Bolanos and Linglart, Agnes and López-Collazo, Eduardo and Lorenzo-Salazar, José M. and Louapre, Céline and Lubetzki, Catherine and Lung, Kwok-Cheung and Luyt, Charles-Edouard and Lye, David C. and Magnone, Cinthia and Marchioni, Enrico and Marioli, Carola and Marjani, Majid and Marques, Laura and Pereira, Jesus Marquez and Martín-Nalda, Andrea and Pueyo, David Martínez and Marzana, Iciar and Mata-Martínez, Carmen and Mathian, Alexis and Matos, Larissa R. B. and Matthews, Gail V. and Mayaux, Julien and McLaughlin-Garcia, Raquel and Meersseman, Philippe and Mège, Jean-Louis and Mekontso-Dessap, Armand and Melki, Isabelle and Meloni, Federica and Meritet, Jean-François and Merlani, Paolo and Akcan, Özge Metin and Meyts, Isabelle and Mezidi, Mehdi and Millereux, Maude and Million, Matthieu and Mirault, Tristan and Mircher, Clotilde and Mirsaeidi, Mehdi and Mizoguchi, Yoko and Modi, Bhavi P. and Mojoli, Francesco and Moncomble, Elsa and Melián, Abián Montesdeoca and Martinez, Antonio Morales and Morandeira, Francisco and Mordacq, Cléemence and Mouly, Stéphane J. and Muñoz-Barrera, Adrián and Nafati, Cyril and Nagashima, Shintaro and Nakagama, Yu and Neven, Bénédicte and Neves, João Farela and Ng, Lisa F. P. and Ng, Yuk-Yung and Nielly, hubert and Medina, Yeray Novoa and Cuadros, Esmeralda Nuñez and Ocejo-Vinyals, J. Gonzalo and Okamoto, Keisuke and Oualha, Mehdi and Ouedrani, Amani and Özçelik, Tayfun and Ozkaya-Parlakay, Aslinur and Pagani, Michele and Papadaki, Maria and Parizot, Christophe and Parola, Philippe and Pascreau, Tiffany and Paul, Stéphane and Paz-Artal, Estela and Pedraza, Sigifredo and Pellecer, Nancy Carolina González and Pellegrini, Silvia and Pérez-Fernández, Xosé Luis and Philippe, Aurélien and Philippot, Quentin and Picod, Adrien and de Chambrun, Marc Pineton and Piralla, Antonio and Ploin, Dominique and Poissy, Julien and Poncelet, Géraldine and Poulakou, Garyphallia and Pouletty, Marie S. and Pourshahnazari, Persia and Qiu-Chen, Jia Li and Quentric, Paul and Rambaud, Thomas and Raoult, Didier and Raoult, Violette and Rebillat, Anne-Sophie and Redin, Claire and Resmini, Léa and Ricart, Pilar and Richard, Jean-Christophe and Rigo-Bonnin, Raúl and rivet, Nadia and Rocamora-Blanch, Gemma and Rodero, Mathieu P. and Rodrigo, Carlos and Rodriguez, Luis Antonio and Rodriguez-Palmero, Agustí and Romero, Carolina Soledad and Rothenbuhler, Anya and Roux, Damien and Rovina, Nikoletta and Rozenberg, Flore and Ruch, Yvon and Ruiz, Montse and del Prado, Maria Yolanda Ruiz and Ruiz-Rodriguez, Juan Carlos and Sabater-Riera, Joan and Saks, Kai and Salagianni, Maria and Sanchez, Oliver and Sánchez-Montalvá, Adrián and Sánchez-Ramón, Silvia and Schidlowski, Laire and Schluter, Agatha and Schmidt, Julien and Schmidt, Matthieu and Schuetz, Catharina and Schweitzer, Cyril E. and Scolari, Francesco and Sediva, Anna and Seijo, Luis and Seminario, Analia Gisela and Sene, Damien and Seng, Piseth and Senoglu, Sevtap and Seppänen, Mikko and Llovich, Alex Serra and Shcherbina, Anna and Siguret, Virginie and Siouti, Eleni and Smadja, David M. and Smith, Nikaia and Solanich, Xavier and Solé-Violán, Jordi and Soler, Catherine and Soler-Palacín, Pere and Sözeri, Betül and Stella, Giulia Maria and Stepanovskiy, Yuriy and Stoclin, Annabelle and Taccone, Fabio and Taupin, Jean-Luc and Tavernier, Simon and Tello, Loreto Vidaur and Terrier, Benjamin and Thiery, Guillaume and Thorball, Christian and Thorn, Karolina and Thumerelle, Caroline and Tolstrup, Martin and Tomasoni, Gabriele and Toubiana, Julie and Alvarez, Josep Trenado and Triantafyllia, Vasiliki and Trouillet-Assant, Sophie and Troya, Jesús and Tsang, Owen T. Y. and Tserel, Liina and Tso, Eugene Y. K. and Tucci, Alessandra and Öz, Şadiye Kübra Tüter and Ursini, Matilde Valeria and Utsumi, Takanori and Uzunhan, Yurdagul and Vabres, Pierre and Valencia-Ramos, Juan and Van Den Rym, Ana Maria and Vandernoot, Isabelle and Velez-Santamaria, Valentina and Veliz, Silvia Patricia Zuniga and Vidigal, Mateus C. and Viel, Sébastien and Villain, Cédric and Vilaire-Meunier, Marie E. and Villar-García, Judit and Vincent, Audrey and Voiriot, Guillaume and Volokha, Alla and Vuotto, Fanny and Wauters, Els and Wauters, Joost and Wu, Alan K. L. and Wu, Tak-Chiu and Yahşi, Aysun and Yesilbas, Osman and Yildiz, Mehmet and Young, Barnaby E. and Yükselmiş, Ufuk and Zatz, Mayana and Zecca, Marco and Zuccaro, Valentina and Van Praet, Jens and Lambrecht, Bart and Van Braeckel, Eva and Bosteels, Cedric and Hoste, Levi and Hoste, Eric and Bauters, Fre and Heijmans, Catherine and Slabbynck, Hans and Naesens, Leslie and Florkin, Benoit and Boulanger, Cécile and Vanderlinden, Dimitri and Abel, Laurent and Berkell, Matilda and Carelli, Valerio and Fiorentino, Alessio and Malhotra, Surbi and Mattiaccio, Alessandro and Pippucci, Tommaso and Seri, Marco and Tacconelli, Evelina and van Agtmael, Michiel and Algera, Anne Geke and Appelman, Brent and van Baarle, Frank and Bax, Diane and Beudel, Martijn and Bogaard, Harm Jan and Bomers, Marije and Bonta, Peter and Bos, Lieuwe and Botta, Michela and de Brabander, Justin and de Bree, Godelieve and de Bruin, Sanne and Buis, David T. P. and Bugiani, Marianna and Bulle, Esther and Cloherty, Osoul Chouchane Alex and Dijkstra, Mirjam and Dongelmans, Dave A. and Dujardin, Romein W. G. and Elbers, Paul and Fleuren, Lucas and Geijtenbeek, Suzanne Geerlings Theo and Girbes, Armand and Goorhuis, Bram and Grobusch, Martin P. and Hafkamp, Florianne and Hagens, Laura and Hamann, Jorg and Harris, Vanessa and Hemke, Robert and Heunks, Sabine M. Hermans Leo and Hollmann, Markus and Horn, Janneke and Hovius, Joppe W. and de Jong, Menno D. and Koning, Rutger and Lim, Endry H. T. and van Mourik, Niels and Nellen, Jeaninne and Nossent, Esther J. and Paulus, Frederique and Peters, Edgar and Pina-Fuentes, Dan A. I. and van der Poll, Tom and Preckel, Bennedikt and Prins, Jan M. and Raasveld, Jorinde and Reijnders, Tom and de Rotte, Maurits C. F. J. and Schinkel, Michiel and Schultz, Marcus J. and Schrauwen, Femke A. P. and Schuurmans, Alex and Schuurmans, Jaap and Sigaloff, Kim and Slim, Marleen A. and Smeele, Patrick and Smit, Marry and Stijnis, Cornelis S. and Stilma, Willemke and Teunissen, Charlotte and Thoral, Patrick and Tsonas, Anissa M. and Tuinman, Pieter R. and van der Valk, Marc and Veelo, Denise and Volleman, Carolien and de Vries, Heder and Vught, Lonneke A. and van Vugt, Michèle and Wouters, Dorien and Zwinderman, A. H. and Brouwer, Matthijs C. and Wiersinga, W. Joost and Vlaar, Alexander P. J. and van de Beek, Diederik and Tompkins, Miranda F. and Alba, Camille and Snow, Andrew L. and Hupalo, Daniel N. and Rosenberger, John and Sukumar, Gauthaman and Wilkerson, Matthew D. and Zhang, Xijun and Lack, Justin and Oler, Andrew J. and Dobbs, Kerry and Danielson, Jeffrey J. and Biondi, Andrea and Bettini, Laura Rachele and D’Angio’, Mariella and Beretta, Ilaria and Imberti, Luisa and Sottini, Alessandra and Quaresima, Virginia and Quiros-Roldan, Eugenia and Rossi, Camillo and Meyts, Isabelle and Zhang, Shen-Ying and Declercq, Jozefien and Puel, Anne and Notarangelo, Luigi D. and Boisson-Dupuis, Stephanie and Su, Helen C. and Boisson, Bertrand and Jouanguy, Emmanuelle and Casanova, Jean-Laurent and Zhang, Qian and Abel, Laurent and Cobat, Aurélie and COVID Human Genetic Effort, [missing] and COVIDeF Study Group, [missing] and French COVID Cohort Study Group, [missing] and CoV-Contact Cohort, [missing] and COVID-STORM Clinicians, [missing] and COVID Clinicians, [missing] and Orchestra Working Group, [missing] and Amsterdam UMC Covid-19 Biobank, [missing] and NIAID-USUHS COVID Study Group, [missing]}},
  issn         = {{1756-994X}},
  journal      = {{GENOME MEDICINE}},
  keywords     = {{Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine,Type I interferon,Immunity,COVID-19,Rare variants}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{25}},
  title        = {{Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19}},
  url          = {{http://doi.org/10.1186/s13073-023-01173-8}},
  volume       = {{15}},
  year         = {{2023}},
}

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