Follow-up of PRRSv-vaccinated piglets born from PRRSv-vaccinated, ELISA-seropositive and ELISA-seronegative sows
- Author
- Jorian Fiers (UGent) , Marylene Tignon, Dominiek Maes (UGent) and Ann-Brigitte Cay
- Organization
- Project
- Abstract
- Vaccination against the porcine reproductive and respiratory syndrome virus (PRRSv) is widely used to prevent production losses in the swine industry. In this study, piglets born from both PRRSv-vaccinated ELISA-seropositive sows (E+ piglets) and PRRSv-vaccinated ELISA-seronegative sows (E- piglets) were followed-up pre-vaccination, 3 weeks post-vaccination (wpv) and 8 wpv in two Belgian farrow-to-finish herds. The aim of the study was to analyze the presence of PRRSv-specific maternally-derived antibodies (MDAs) and the PRRSv vaccine response in both groups of piglets. The E- piglets lacked the presence of PRRSv-specific MDAs (0% seropositive), while these were present in the E+ piglets (97% seropositive). Due to this, the E- piglets showed a strong initial vaccine response (72-80% seroconversion) and vaccine viremia (65-75% PCR positive) at 3 wpv. In contrast, the E+ piglets showed only limited initial vaccine responses (25-61% with increased ELISA values) and vaccine viremia (30-31% PCR positive) at 3 wpv. By 8 wpv, the proportion of seropositive E- piglets (78-100%) and seropositive E+ piglets (55-90%) increased in both herds. However, a difference in vaccine viremia duration was observed between both herds at 8 wpv, with a decrease in the proportion of PCR positive piglets in herd 1 (E-: 47%; E+: 25%) and an increase in the proportion of PCR positive piglets in herd 2 (E-: 85%; E+: 92%). This study identified clear differences in the presence of PRRSv-specific maternally-derived antibodies and PRRSv vaccine responses between E- and E+ piglets. Further research is warranted to elicit the biological relevance of these observed differences.
- Keywords
- PRRSv, vaccination, immunology, maternally-derived antibodies, seroconversion, RESPIRATORY SYNDROME VIRUS, RECOMBINATION, STRAIN
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GXDRBW57FMKV0A8P9FMXJVDC
- MLA
- Fiers, Jorian, et al. “Follow-up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows.” VIRUSES-BASEL, vol. 15, no. 2, MDPI, 2023, doi:10.3390/v15020479.
- APA
- Fiers, J., Tignon, M., Maes, D., & Cay, A.-B. (2023). Follow-up of PRRSv-vaccinated piglets born from PRRSv-vaccinated, ELISA-seropositive and ELISA-seronegative sows. VIRUSES-BASEL, 15(2). https://doi.org/10.3390/v15020479
- Chicago author-date
- Fiers, Jorian, Marylene Tignon, Dominiek Maes, and Ann-Brigitte Cay. 2023. “Follow-up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows.” VIRUSES-BASEL 15 (2). https://doi.org/10.3390/v15020479.
- Chicago author-date (all authors)
- Fiers, Jorian, Marylene Tignon, Dominiek Maes, and Ann-Brigitte Cay. 2023. “Follow-up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows.” VIRUSES-BASEL 15 (2). doi:10.3390/v15020479.
- Vancouver
- 1.Fiers J, Tignon M, Maes D, Cay A-B. Follow-up of PRRSv-vaccinated piglets born from PRRSv-vaccinated, ELISA-seropositive and ELISA-seronegative sows. VIRUSES-BASEL. 2023;15(2).
- IEEE
- [1]J. Fiers, M. Tignon, D. Maes, and A.-B. Cay, “Follow-up of PRRSv-vaccinated piglets born from PRRSv-vaccinated, ELISA-seropositive and ELISA-seronegative sows,” VIRUSES-BASEL, vol. 15, no. 2, 2023.
@article{01GXDRBW57FMKV0A8P9FMXJVDC,
abstract = {{Vaccination against the porcine reproductive and respiratory syndrome virus (PRRSv) is widely used to prevent production losses in the swine industry. In this study, piglets born from both PRRSv-vaccinated ELISA-seropositive sows (E+ piglets) and PRRSv-vaccinated ELISA-seronegative sows (E- piglets) were followed-up pre-vaccination, 3 weeks post-vaccination (wpv) and 8 wpv in two Belgian farrow-to-finish herds. The aim of the study was to analyze the presence of PRRSv-specific maternally-derived antibodies (MDAs) and the PRRSv vaccine response in both groups of piglets. The E- piglets lacked the presence of PRRSv-specific MDAs (0% seropositive), while these were present in the E+ piglets (97% seropositive). Due to this, the E- piglets showed a strong initial vaccine response (72-80% seroconversion) and vaccine viremia (65-75% PCR positive) at 3 wpv. In contrast, the E+ piglets showed only limited initial vaccine responses (25-61% with increased ELISA values) and vaccine viremia (30-31% PCR positive) at 3 wpv. By 8 wpv, the proportion of seropositive E- piglets (78-100%) and seropositive E+ piglets (55-90%) increased in both herds. However, a difference in vaccine viremia duration was observed between both herds at 8 wpv, with a decrease in the proportion of PCR positive piglets in herd 1 (E-: 47%; E+: 25%) and an increase in the proportion of PCR positive piglets in herd 2 (E-: 85%; E+: 92%). This study identified clear differences in the presence of PRRSv-specific maternally-derived antibodies and PRRSv vaccine responses between E- and E+ piglets. Further research is warranted to elicit the biological relevance of these observed differences.}},
articleno = {{479}},
author = {{Fiers, Jorian and Tignon, Marylene and Maes, Dominiek and Cay, Ann-Brigitte}},
issn = {{1999-4915}},
journal = {{VIRUSES-BASEL}},
keywords = {{PRRSv,vaccination,immunology,maternally-derived antibodies,seroconversion,RESPIRATORY SYNDROME VIRUS,RECOMBINATION,STRAIN}},
language = {{eng}},
number = {{2}},
pages = {{16}},
publisher = {{MDPI}},
title = {{Follow-up of PRRSv-vaccinated piglets born from PRRSv-vaccinated, ELISA-seropositive and ELISA-seronegative sows}},
url = {{http://doi.org/10.3390/v15020479}},
volume = {{15}},
year = {{2023}},
}
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