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Potential of urine biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and combinations as complementary diagnostic tools for acute kidney injury after pediatric cardiac surgery : a prospective cohort study

Wim Vandenberghe (UGent) , Jorien De Loor (UGent) , Katrien Francois (UGent) , Kristof Vandekerckhove (UGent) , Ingrid Herck (UGent) , Johan Vande Walle (UGent) , Harlinde Peperstraete (UGent) , Thierry Bové (UGent) , Daniël De Wolf (UGent) , Lieve Nuytinck (UGent) , et al.
(2023) DIAGNOSTICS. 13(6).
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Abstract
Acute kidney injury (AKI) is common after pediatric cardiac surgery (CS). Several urine biomarkers have been validated to detect AKI earlier. The objective of this study was to evaluate urine CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) as predictors for AKI >= 1 in pediatric CS after 48 h and AKI >= 2 after 12 h. Pediatric patients (age < 18 year; body weight >= 2 kg) requiring CS were prospectively included. Urine CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) were measured during surgery and intensive care unit (ICU) stay and corrected for urine dilution. One hundred and one pediatric patients were included. AKI >= 1 within 48 h after ICU admission occurred in 62.4% and AKI >= 2 within 12 h in 30.7%. All damage biomarkers predicted AKI >= 1 within 48 h after ICU admission, when corrected for urine dilution: CHI3L1 (AUC-ROC: 0.642 (95% CI, 0.535-0.741)), NGAL (0.765 (0.664-0.848)), TIMP-2 (0.778 (0.662-0.868)), IGFBP7 (0.796 (0.682-0.883)), NephroCheck(R) (0.734 (0.614-0.832)). Similarly, AKI >= 2 within 12 h was predicted by all damage biomarkers when corrected for urine dilution: uCHI3L1 (AUC-ROC: 0.686 (95% CI, 0.580-0.780)), NGAL (0.714 (0.609-0.804)), TIMP-2 (0.830 (0.722-0.909)), IGFBP7 (0.834 (0.725-0.912)), NephroCheck(R) (0.774 (0.658-0.865)). After pediatric cardiac surgery, the damage biomarkers urine CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) reliably predict AKI after correction for urine dilution.
Keywords
cardiac surgery, pediatric, urine biomarker, AKI

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MLA
Vandenberghe, Wim, et al. “Potential of Urine Biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and Combinations as Complementary Diagnostic Tools for Acute Kidney Injury after Pediatric Cardiac Surgery : A Prospective Cohort Study.” DIAGNOSTICS, vol. 13, no. 6, 2023, doi:10.3390/diagnostics13061047.
APA
Vandenberghe, W., De Loor, J., Francois, K., Vandekerckhove, K., Herck, I., Vande Walle, J., … Hoste, E. (2023). Potential of urine biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and combinations as complementary diagnostic tools for acute kidney injury after pediatric cardiac surgery : a prospective cohort study. DIAGNOSTICS, 13(6). https://doi.org/10.3390/diagnostics13061047
Chicago author-date
Vandenberghe, Wim, Jorien De Loor, Katrien Francois, Kristof Vandekerckhove, Ingrid Herck, Johan Vande Walle, Harlinde Peperstraete, et al. 2023. “Potential of Urine Biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and Combinations as Complementary Diagnostic Tools for Acute Kidney Injury after Pediatric Cardiac Surgery : A Prospective Cohort Study.” DIAGNOSTICS 13 (6). https://doi.org/10.3390/diagnostics13061047.
Chicago author-date (all authors)
Vandenberghe, Wim, Jorien De Loor, Katrien Francois, Kristof Vandekerckhove, Ingrid Herck, Johan Vande Walle, Harlinde Peperstraete, Thierry Bové, Daniël De Wolf, Lieve Nuytinck, Jan De Waele, Evelyne Meyer, and Eric Hoste. 2023. “Potential of Urine Biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and Combinations as Complementary Diagnostic Tools for Acute Kidney Injury after Pediatric Cardiac Surgery : A Prospective Cohort Study.” DIAGNOSTICS 13 (6). doi:10.3390/diagnostics13061047.
Vancouver
1.
Vandenberghe W, De Loor J, Francois K, Vandekerckhove K, Herck I, Vande Walle J, et al. Potential of urine biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and combinations as complementary diagnostic tools for acute kidney injury after pediatric cardiac surgery : a prospective cohort study. DIAGNOSTICS. 2023;13(6).
IEEE
[1]
W. Vandenberghe et al., “Potential of urine biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and combinations as complementary diagnostic tools for acute kidney injury after pediatric cardiac surgery : a prospective cohort study,” DIAGNOSTICS, vol. 13, no. 6, 2023.
@article{01GX6CFEV2HXY0GRHAQ4NJMTTA,
  abstract     = {{Acute kidney injury (AKI) is common after pediatric cardiac surgery (CS). Several urine biomarkers have been validated to detect AKI earlier. The objective of this study was to evaluate urine CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) as predictors for AKI >= 1 in pediatric CS after 48 h and AKI >= 2 after 12 h. Pediatric patients (age < 18 year; body weight >= 2 kg) requiring CS were prospectively included. Urine CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) were measured during surgery and intensive care unit (ICU) stay and corrected for urine dilution. One hundred and one pediatric patients were included. AKI >= 1 within 48 h after ICU admission occurred in 62.4% and AKI >= 2 within 12 h in 30.7%. All damage biomarkers predicted AKI >= 1 within 48 h after ICU admission, when corrected for urine dilution: CHI3L1 (AUC-ROC: 0.642 (95% CI, 0.535-0.741)), NGAL (0.765 (0.664-0.848)), TIMP-2 (0.778 (0.662-0.868)), IGFBP7 (0.796 (0.682-0.883)), NephroCheck(R) (0.734 (0.614-0.832)). Similarly, AKI >= 2 within 12 h was predicted by all damage biomarkers when corrected for urine dilution: uCHI3L1 (AUC-ROC: 0.686 (95% CI, 0.580-0.780)), NGAL (0.714 (0.609-0.804)), TIMP-2 (0.830 (0.722-0.909)), IGFBP7 (0.834 (0.725-0.912)), NephroCheck(R) (0.774 (0.658-0.865)). After pediatric cardiac surgery, the damage biomarkers urine CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) reliably predict AKI after correction for urine dilution.}},
  articleno    = {{1047}},
  author       = {{Vandenberghe, Wim and De Loor, Jorien and Francois, Katrien and Vandekerckhove, Kristof and Herck, Ingrid and Vande Walle, Johan and Peperstraete, Harlinde and Bové, Thierry and De Wolf, Daniël and Nuytinck, Lieve and De Waele, Jan and Meyer, Evelyne and Hoste, Eric}},
  issn         = {{2075-4418}},
  journal      = {{DIAGNOSTICS}},
  keywords     = {{cardiac surgery,pediatric,urine biomarker,AKI}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{17}},
  title        = {{Potential of urine biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and combinations as complementary diagnostic tools for acute kidney injury after pediatric cardiac surgery : a prospective cohort study}},
  url          = {{http://doi.org/10.3390/diagnostics13061047}},
  volume       = {{13}},
  year         = {{2023}},
}

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