SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry
- Author
- Bieke Decaesteker (UGent) , Amber Louwagie (UGent) , Siebe Loontiens (UGent) , Fanny De Vloed (UGent) , Sarah-Lee Bekaert (UGent) , Juliette Roels (UGent) , Suzanne Vanhauwaert (UGent) , Sara De Brouwer (UGent) , Ellen Sanders, A Berezovskaya, Geertrui Denecker (UGent) , Eva D'haene (UGent) , Stéphane Van Haver (UGent) , Wouter Van Loocke (UGent) , Jo Van Dorpe (UGent) , David Creytens (UGent) , Nadine Van Roy (UGent) , Tim Pieters (UGent) , Christophe Van Neste (UGent) , M Fischer, Pieter Van Vlierberghe (UGent) , SS Roberts, J Schulte, S Ek, R Versteeg, J Koster, J van Nes, M Zimmerman, Katleen De Preter (UGent) and Franki Speleman (UGent)
- Organization
- Project
-
- Deregulated transcriptional networks of regulatory miRNAs and protein coding genes in the pathogenesis of cancer
- Long noncoding RNAs in cancer: deciphering the functional role of the dark matter of the human cancer genome
- The role of the SOX11 lineage-dependency factor as epigenetic master regulator in neuroblastoma
- Cancer cells and their microenvironment: from gene regulatory networks to therapy
- Reconstruction of dynamic initiation and progression gene expression regulatory networks in neuroblastoma
- Reconstruction of functional molecular networks in ALK mutated neuroblastomas
- Replicative stress induced DNA damage response signaling at the crossroad between embryonic stem cells and MYC(N) driven tumours
- The neuroblastoma 17q enigma: exploiting zebrafish modeling to study the cooperative role of 17q genes in MYCN driven tumor formation
- 3G0D9415
- Transcan-2 cofund JTC 2014
- ENCCA (European Network for Cancer research in Children and Adolescents (ENCCA))
- ASSET (Analysing and Striking the Sensitivities of Embryonal Tumours)
- The SOX11 transcription factor as “lineage survival” oncogene in neuroblastoma
- The role of super-enhancer regulated SOX11 in regulation of SWI/SNF and PRC2 activity in adrenergic neuroblastoma
- A human pluripotent stem cell derived differentiation model for the study of normal and transformed sympathoadrenal progenitors
- Abstract
- The development of neuroblastoma (NB) is regulated by multiple core transcription factors. Here, SOX11 is identified as a potential epigenetic master regulator upstream of the core regulatory circuitry in adrenergic high-risk neuroblastoma. The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases. Here, we identify SOX11 as a dependency transcription factor in adrenergic neuroblastoma based on recurrent chromosome 2p focal gains and amplifications, specific expression in the normal sympatho-adrenal lineage and adrenergic neuroblastoma, regulation by multiple adrenergic specific (super-)enhancers and strong dependency on high SOX11 expression in adrenergic neuroblastomas. SOX11 regulated direct targets include genes implicated in epigenetic control, cytoskeleton and neurodevelopment. Most notably, SOX11 controls chromatin regulatory complexes, including 10 SWI/SNF core components among which SMARCC1, SMARCA4/BRG1 and ARID1A. Additionally, the histone deacetylase HDAC2, PRC1 complex component CBX2, chromatin-modifying enzyme KDM1A/LSD1 and pioneer factor c-MYB are regulated by SOX11. Finally, SOX11 is identified as a core transcription factor of the core regulatory circuitry (CRC) in adrenergic high-risk neuroblastoma with a potential role as epigenetic master regulator upstream of the CRC.
Downloads
-
sox11 nat commun 2023.pdf
- full text (Published version)
- |
- open access
- |
- |
- 5.26 MB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GWM3X9HW8QEDXYKMZHR168Q1
- MLA
- Decaesteker, Bieke, et al. “SOX11 Regulates SWI/SNF Complex Components as Member of the Adrenergic Neuroblastoma Core Regulatory Circuitry.” NATURE COMMUNICATIONS, vol. 14, no. 1, 2023, doi:10.1038/s41467-023-36735-2.
- APA
- Decaesteker, B., Louwagie, A., Loontiens, S., De Vloed, F., Bekaert, S.-L., Roels, J., … Speleman, F. (2023). SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry. NATURE COMMUNICATIONS, 14(1). https://doi.org/10.1038/s41467-023-36735-2
- Chicago author-date
- Decaesteker, Bieke, Amber Louwagie, Siebe Loontiens, Fanny De Vloed, Sarah-Lee Bekaert, Juliette Roels, Suzanne Vanhauwaert, et al. 2023. “SOX11 Regulates SWI/SNF Complex Components as Member of the Adrenergic Neuroblastoma Core Regulatory Circuitry.” NATURE COMMUNICATIONS 14 (1). https://doi.org/10.1038/s41467-023-36735-2.
- Chicago author-date (all authors)
- Decaesteker, Bieke, Amber Louwagie, Siebe Loontiens, Fanny De Vloed, Sarah-Lee Bekaert, Juliette Roels, Suzanne Vanhauwaert, Sara De Brouwer, Ellen Sanders, A Berezovskaya, Geertrui Denecker, Eva D’haene, Stéphane Van Haver, Wouter Van Loocke, Jo Van Dorpe, David Creytens, Nadine Van Roy, Tim Pieters, Christophe Van Neste, M Fischer, Pieter Van Vlierberghe, SS Roberts, J Schulte, S Ek, R Versteeg, J Koster, J van Nes, M Zimmerman, Katleen De Preter, and Franki Speleman. 2023. “SOX11 Regulates SWI/SNF Complex Components as Member of the Adrenergic Neuroblastoma Core Regulatory Circuitry.” NATURE COMMUNICATIONS 14 (1). doi:10.1038/s41467-023-36735-2.
- Vancouver
- 1.Decaesteker B, Louwagie A, Loontiens S, De Vloed F, Bekaert S-L, Roels J, et al. SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry. NATURE COMMUNICATIONS. 2023;14(1).
- IEEE
- [1]B. Decaesteker et al., “SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry,” NATURE COMMUNICATIONS, vol. 14, no. 1, 2023.
@article{01GWM3X9HW8QEDXYKMZHR168Q1,
abstract = {{The development of neuroblastoma (NB) is regulated by multiple core transcription factors. Here, SOX11 is identified as a potential epigenetic master regulator upstream of the core regulatory circuitry in adrenergic high-risk neuroblastoma.
The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases. Here, we identify SOX11 as a dependency transcription factor in adrenergic neuroblastoma based on recurrent chromosome 2p focal gains and amplifications, specific expression in the normal sympatho-adrenal lineage and adrenergic neuroblastoma, regulation by multiple adrenergic specific (super-)enhancers and strong dependency on high SOX11 expression in adrenergic neuroblastomas. SOX11 regulated direct targets include genes implicated in epigenetic control, cytoskeleton and neurodevelopment. Most notably, SOX11 controls chromatin regulatory complexes, including 10 SWI/SNF core components among which SMARCC1, SMARCA4/BRG1 and ARID1A. Additionally, the histone deacetylase HDAC2, PRC1 complex component CBX2, chromatin-modifying enzyme KDM1A/LSD1 and pioneer factor c-MYB are regulated by SOX11. Finally, SOX11 is identified as a core transcription factor of the core regulatory circuitry (CRC) in adrenergic high-risk neuroblastoma with a potential role as epigenetic master regulator upstream of the CRC.}},
articleno = {{1267}},
author = {{Decaesteker, Bieke and Louwagie, Amber and Loontiens, Siebe and De Vloed, Fanny and Bekaert, Sarah-Lee and Roels, Juliette and Vanhauwaert, Suzanne and De Brouwer, Sara and Sanders, Ellen and Berezovskaya, A and Denecker, Geertrui and D'haene, Eva and Van Haver, Stéphane and Van Loocke, Wouter and Van Dorpe, Jo and Creytens, David and Van Roy, Nadine and Pieters, Tim and Van Neste, Christophe and Fischer, M and Van Vlierberghe, Pieter and Roberts, SS and Schulte, J and Ek, S and Versteeg, R and Koster, J and van Nes, J and Zimmerman, M and De Preter, Katleen and Speleman, Franki}},
issn = {{2041-1723}},
journal = {{NATURE COMMUNICATIONS}},
language = {{eng}},
number = {{1}},
pages = {{16}},
title = {{SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry}},
url = {{http://doi.org/10.1038/s41467-023-36735-2}},
volume = {{14}},
year = {{2023}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: