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ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis

(2023) CURRENT BIOLOGY. 33(9). p.1778-1786
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Abstract
Nutrient sensing and signaling are essential for adjusting growth and development to available resources. Deprivation of the essential mineral phosphorus (P) inhibits root growth.1 The molecular processes that sense P limitation to trigger early root growth inhibition are not known yet. Target of rapamycin (TOR) kinase is a central regulatory hub in eukaryotes to adapt growth to internal and external nutritional cues.2,3 How nutritional signals are transduced to TOR to control plant growth remains unclear. Here, we identify Arabidopsis-root-specific kinase 1 (ARSK1), which attenuates initial root growth inhibition in response to P limitation. We demonstrate that ARSK1 phosphorylates and stabilizes the regulatory-associated protein of TOR 1B (RAPTOR1B), a component of the TOR complex 1, to adjust root growth to P availability. These findings uncover signaling components acting upstream of TOR to balance growth to P availability.
Keywords
ARSK1, Arabidopsis, RAPTOR1B, TOR, TORC1 signaling, early signaling, phosphorus deficiency, phosphorylation, root growth., PLANT-GROWTH, ROOT-GROWTH, DEFICIENCY, EXPRESSION, IDENTIFICATION, STARVATION, NUTRIENT, PROGRAM, IRON

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MLA
Cho, Huikyong, et al. “ARSK1 Activates TORC1 Signaling to Adjust Growth to Phosphate Availability in Arabidopsis.” CURRENT BIOLOGY, vol. 33, no. 9, 2023, pp. 1778–86, doi:10.1016/j.cub.2023.03.005.
APA
Cho, H., Banf, M., Shahzad, Z., Van Leene, J., Bossi, F., Ruffel, S., … Rouached, H. (2023). ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis. CURRENT BIOLOGY, 33(9), 1778–1786. https://doi.org/10.1016/j.cub.2023.03.005
Chicago author-date
Cho, Huikyong, Michael Banf, Zaigham Shahzad, Jelle Van Leene, Flavia Bossi, Sandrine Ruffel, Nadia Bouain, et al. 2023. “ARSK1 Activates TORC1 Signaling to Adjust Growth to Phosphate Availability in Arabidopsis.” CURRENT BIOLOGY 33 (9): 1778–86. https://doi.org/10.1016/j.cub.2023.03.005.
Chicago author-date (all authors)
Cho, Huikyong, Michael Banf, Zaigham Shahzad, Jelle Van Leene, Flavia Bossi, Sandrine Ruffel, Nadia Bouain, Pengfei Cao, Gabiel Krouk, Geert De Jaeger, Benoit Lacombe, Federica Brandizzi, Seung Y. Rhee, and Hatem Rouached. 2023. “ARSK1 Activates TORC1 Signaling to Adjust Growth to Phosphate Availability in Arabidopsis.” CURRENT BIOLOGY 33 (9): 1778–1786. doi:10.1016/j.cub.2023.03.005.
Vancouver
1.
Cho H, Banf M, Shahzad Z, Van Leene J, Bossi F, Ruffel S, et al. ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis. CURRENT BIOLOGY. 2023;33(9):1778–86.
IEEE
[1]
H. Cho et al., “ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis,” CURRENT BIOLOGY, vol. 33, no. 9, pp. 1778–1786, 2023.
@article{01GWKY93S7T7DRPP9AD2FQ2YHX,
  abstract     = {{Nutrient sensing and signaling are essential for adjusting growth and development to available resources. Deprivation of the essential mineral phosphorus (P) inhibits root growth.1 The molecular processes that sense P limitation to trigger early root growth inhibition are not known yet. Target of rapamycin (TOR) kinase is a central regulatory hub in eukaryotes to adapt growth to internal and external nutritional cues.2,3 How nutritional signals are transduced to TOR to control plant growth remains unclear. Here, we identify Arabidopsis-root-specific kinase 1 (ARSK1), which attenuates initial root growth inhibition in response to P limitation. We demonstrate that ARSK1 phosphorylates and stabilizes the regulatory-associated protein of TOR 1B (RAPTOR1B), a component of the TOR complex 1, to adjust root growth to P availability. These findings uncover signaling components acting upstream of TOR to balance growth to P availability.}},
  author       = {{Cho, Huikyong and Banf, Michael and Shahzad, Zaigham and Van Leene, Jelle and Bossi, Flavia and Ruffel, Sandrine and Bouain, Nadia and Cao, Pengfei and Krouk, Gabiel and De Jaeger, Geert and Lacombe, Benoit and Brandizzi, Federica and Rhee, Seung Y. and Rouached, Hatem}},
  issn         = {{0960-9822}},
  journal      = {{CURRENT BIOLOGY}},
  keywords     = {{ARSK1,Arabidopsis,RAPTOR1B,TOR,TORC1 signaling,early signaling,phosphorus deficiency,phosphorylation,root growth.,PLANT-GROWTH,ROOT-GROWTH,DEFICIENCY,EXPRESSION,IDENTIFICATION,STARVATION,NUTRIENT,PROGRAM,IRON}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1778--1786}},
  title        = {{ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis}},
  url          = {{http://doi.org/10.1016/j.cub.2023.03.005}},
  volume       = {{33}},
  year         = {{2023}},
}

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