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Ray tracing optimization : a new method for intraocular lens power calculation in regular and irregular corneas

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Abstract
To develop a novel algorithm based on ray tracing, simulated visual performance and through-focus optimization for an accurate intraocular lens (IOL) power calculation. Custom-developed algorithms for ray tracing optimization (RTO) were used to combine the natural corneal higher-order aberrations (HOAs) with multiple sphero-cylindrical corrections in 210 higher order statistical eye models for developing keratoconus. The magnitude of defocus and astigmatism producing the maximum Visual Strehl was considered as the optimal sphero-cylindrical target for IOL power calculation. Corneal astigmatism and the RMS HOAs ranged from - 0.64 +/- 0.35D and 0.10 +/- 0.04 mu m (0-months) to - 3.15 +/- 1.38D and 0.82 +/- 0.47 mu m (120-months). Defocus and astigmatism target was close to neutral for eyes with low amount of HOAs (0 and 12-months), where 91.66% of eyes agreed within +/- 0.50D in IOL power calculation (RTO vs. SRK/T). However, corneas with higher amounts of HOAs presented greater visual improvement with an optimized target. In these eyes (24- to 120-months), only 18.05% of eyes agreed within +/- 0.50D (RTO vs. SRK/T). The power difference exceeded 3D in 42.2% while the cylinder required adjustments larger than 3D in 18.4% of the cases. Certain amounts of lower and HOAs may interact favourably to improve visual performance, shifting therefore the refractive target for IOL power calculation.
Keywords
IMAGE QUALITY, RETINAL IMAGE, REPEATABILITY, ACCURACY, ASTIGMATISM, AGREEMENT, OUTCOMES, SYSTEMS, PREDICTION, ABERRATION

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MLA
Perez Merino, Pablo, et al. “Ray Tracing Optimization : A New Method for Intraocular Lens Power Calculation in Regular and Irregular Corneas.” SCIENTIFIC REPORTS, vol. 13, no. 1, 2023, doi:10.1038/s41598-023-31525-8.
APA
Perez Merino, P., Aramberri, J., Vasquez Quintero, A. F., & Rozema, J. J. (2023). Ray tracing optimization : a new method for intraocular lens power calculation in regular and irregular corneas. SCIENTIFIC REPORTS, 13(1). https://doi.org/10.1038/s41598-023-31525-8
Chicago author-date
Perez Merino, Pablo, Jaime Aramberri, Andrés Felipe Vasquez Quintero, and Jos J. Rozema. 2023. “Ray Tracing Optimization : A New Method for Intraocular Lens Power Calculation in Regular and Irregular Corneas.” SCIENTIFIC REPORTS 13 (1). https://doi.org/10.1038/s41598-023-31525-8.
Chicago author-date (all authors)
Perez Merino, Pablo, Jaime Aramberri, Andrés Felipe Vasquez Quintero, and Jos J. Rozema. 2023. “Ray Tracing Optimization : A New Method for Intraocular Lens Power Calculation in Regular and Irregular Corneas.” SCIENTIFIC REPORTS 13 (1). doi:10.1038/s41598-023-31525-8.
Vancouver
1.
Perez Merino P, Aramberri J, Vasquez Quintero AF, Rozema JJ. Ray tracing optimization : a new method for intraocular lens power calculation in regular and irregular corneas. SCIENTIFIC REPORTS. 2023;13(1).
IEEE
[1]
P. Perez Merino, J. Aramberri, A. F. Vasquez Quintero, and J. J. Rozema, “Ray tracing optimization : a new method for intraocular lens power calculation in regular and irregular corneas,” SCIENTIFIC REPORTS, vol. 13, no. 1, 2023.
@article{01GW6W5X55VZ0YHD2K9YSDQWDF,
  abstract     = {{To develop a novel algorithm based on ray tracing, simulated visual performance and through-focus optimization for an accurate intraocular lens (IOL) power calculation. Custom-developed algorithms for ray tracing optimization (RTO) were used to combine the natural corneal higher-order aberrations (HOAs) with multiple sphero-cylindrical corrections in 210 higher order statistical eye models for developing keratoconus. The magnitude of defocus and astigmatism producing the maximum Visual Strehl was considered as the optimal sphero-cylindrical target for IOL power calculation. Corneal astigmatism and the RMS HOAs ranged from - 0.64 +/- 0.35D and 0.10 +/- 0.04 mu m (0-months) to - 3.15 +/- 1.38D and 0.82 +/- 0.47 mu m (120-months). Defocus and astigmatism target was close to neutral for eyes with low amount of HOAs (0 and 12-months), where 91.66% of eyes agreed within +/- 0.50D in IOL power calculation (RTO vs. SRK/T). However, corneas with higher amounts of HOAs presented greater visual improvement with an optimized target. In these eyes (24- to 120-months), only 18.05% of eyes agreed within +/- 0.50D (RTO vs. SRK/T). The power difference exceeded 3D in 42.2% while the cylinder required adjustments larger than 3D in 18.4% of the cases. Certain amounts of lower and HOAs may interact favourably to improve visual performance, shifting therefore the refractive target for IOL power calculation.}},
  articleno    = {{4555}},
  author       = {{Perez Merino, Pablo and Aramberri, Jaime and Vasquez Quintero, Andrés Felipe and Rozema, Jos J.}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{IMAGE QUALITY,RETINAL IMAGE,REPEATABILITY,ACCURACY,ASTIGMATISM,AGREEMENT,OUTCOMES,SYSTEMS,PREDICTION,ABERRATION}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{11}},
  title        = {{Ray tracing optimization : a new method for intraocular lens power calculation in regular and irregular corneas}},
  url          = {{http://doi.org/10.1038/s41598-023-31525-8}},
  volume       = {{13}},
  year         = {{2023}},
}

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