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Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14-15 years) from the Flemish environment and health

Michiel Bastiaensen, Celine Gys, Ann Colles, Veerle Verheyen, Gudrun Koppen, Eva Govarts, Liesbeth Bruckers, Bert Morrens, Ilse Loots, Annelies De Decker, et al.
(2021) ENVIRONMENT INTERNATIONAL. 147.
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Abstract
The ubiquitous use of organophosphate flame retardants and plasticizers (PFRs) in a variety of consumer products has led to widespread human exposure. Since certain PFRs are developmental and carcinogenic toxicants, detailed exposure assessments are essential to investigate the risk associated with environmental exposure levels. However, such data are still lacking for European countries. In this study, concentrations of thirteen PFR metabolites were measured in urine samples from 600 adolescents from Flanders, Belgium. 1-Hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP), diphenyl phosphate (DPHP), bis(1,3-dichloro-isopropyl) phosphate (BDCIPP), 2-hydroxyethyl bis(2-butoxyethyl) phosphate (BBOEHEP), 2-ethylhexyl phenyl phosphate (EHPHP) and 2-ethyl-5-hydroxyhexyl diphenyl phosphate (5-HO-EHDPHP) were frequently detected (>83%) in all participants. Comparisons with study populations from outside the EU showed that urinary levels of DPHP, BDCIPP and BCIPHIPP were generally within the same range. Only exposure to 2-ethylhexyl diphenyl phosphate (EHDPHP) was presumably higher in Flemish adolescents. However, determinants analysis through multivariate regression analyses did not reveal significant predictors that may explain this finding. Significantly higher levels of BDCIPP were observed in participants with new decorations at home, while adolescents with highly educated parents had higher levels of BBOEHEP and BDCIPP. Furthermore, multiple PFR metabolite concentrations followed a seasonal pattern. Estimated daily intakes (EDIs) were calculated from the internal dose by including fractions of urinary excretion (FUE) estimated in in vitro metabolism studies. EDIs ranged from 6.3 ng/kg bw/day for TBOEP to 567.7 ng/kg bw/day for EHDPHP, which were well below the available oral reference doses for all investigated PFRs. This suggests that the associated risk is low at present. This is the first report on internal exposure to seven commonly used PFRs in a European population.
Keywords
Organophosphate flame retardants, Exposure assessment, Human, biomonitoring, FLEHS IV, Belgium, Adolescents

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MLA
Bastiaensen, Michiel, et al. “Exposure Levels, Determinants and Risk Assessment of Organophosphate Flame Retardants and Plasticizers in Adolescents (14-15 Years) from the Flemish Environment and Health.” ENVIRONMENT INTERNATIONAL, vol. 147, Pergamon-Elsevier Science LTD, 2021, doi:10.1016/j.envint.2020.106368.
APA
Bastiaensen, M., Gys, C., Colles, A., Verheyen, V., Koppen, G., Govarts, E., … Covaci, A. (2021). Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14-15 years) from the Flemish environment and health. ENVIRONMENT INTERNATIONAL, 147. https://doi.org/10.1016/j.envint.2020.106368
Chicago author-date
Bastiaensen, Michiel, Celine Gys, Ann Colles, Veerle Verheyen, Gudrun Koppen, Eva Govarts, Liesbeth Bruckers, et al. 2021. “Exposure Levels, Determinants and Risk Assessment of Organophosphate Flame Retardants and Plasticizers in Adolescents (14-15 Years) from the Flemish Environment and Health.” ENVIRONMENT INTERNATIONAL 147. https://doi.org/10.1016/j.envint.2020.106368.
Chicago author-date (all authors)
Bastiaensen, Michiel, Celine Gys, Ann Colles, Veerle Verheyen, Gudrun Koppen, Eva Govarts, Liesbeth Bruckers, Bert Morrens, Ilse Loots, Annelies De Decker, Vera Nelen, Tim Nawrot, Stefaan De Henauw, Nik Van Larebeke, Greet Schoeters, and Adrian Covaci. 2021. “Exposure Levels, Determinants and Risk Assessment of Organophosphate Flame Retardants and Plasticizers in Adolescents (14-15 Years) from the Flemish Environment and Health.” ENVIRONMENT INTERNATIONAL 147. doi:10.1016/j.envint.2020.106368.
Vancouver
1.
Bastiaensen M, Gys C, Colles A, Verheyen V, Koppen G, Govarts E, et al. Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14-15 years) from the Flemish environment and health. ENVIRONMENT INTERNATIONAL. 2021;147.
IEEE
[1]
M. Bastiaensen et al., “Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14-15 years) from the Flemish environment and health,” ENVIRONMENT INTERNATIONAL, vol. 147, 2021.
@article{01GW4DDQSENZ1696SNBFGVNDM3,
  abstract     = {{The ubiquitous use of organophosphate flame retardants and plasticizers (PFRs) in a variety of consumer products has led to widespread human exposure. Since certain PFRs are developmental and carcinogenic toxicants, detailed exposure assessments are essential to investigate the risk associated with environmental exposure levels. However, such data are still lacking for European countries. In this study, concentrations of thirteen PFR metabolites were measured in urine samples from 600 adolescents from Flanders, Belgium. 1-Hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP), diphenyl phosphate (DPHP), bis(1,3-dichloro-isopropyl) phosphate (BDCIPP), 2-hydroxyethyl bis(2-butoxyethyl) phosphate (BBOEHEP), 2-ethylhexyl phenyl phosphate (EHPHP) and 2-ethyl-5-hydroxyhexyl diphenyl phosphate (5-HO-EHDPHP) were frequently detected (>83%) in all participants. Comparisons with study populations from outside the EU showed that urinary levels of DPHP, BDCIPP and BCIPHIPP were generally within the same range. Only exposure to 2-ethylhexyl diphenyl phosphate (EHDPHP) was presumably higher in Flemish adolescents. However, determinants analysis through multivariate regression analyses did not reveal significant predictors that may explain this finding. Significantly higher levels of BDCIPP were observed in participants with new decorations at home, while adolescents with highly educated parents had higher levels of BBOEHEP and BDCIPP. Furthermore, multiple PFR metabolite concentrations followed a seasonal pattern. Estimated daily intakes (EDIs) were calculated from the internal dose by including fractions of urinary excretion (FUE) estimated in in vitro metabolism studies. EDIs ranged from 6.3 ng/kg bw/day for TBOEP to 567.7 ng/kg bw/day for EHDPHP, which were well below the available oral reference doses for all investigated PFRs. This suggests that the associated risk is low at present. This is the first report on internal exposure to seven commonly used PFRs in a European population.}},
  articleno    = {{106368}},
  author       = {{Bastiaensen, Michiel and  Gys, Celine and  Colles, Ann and  Verheyen, Veerle and  Koppen, Gudrun and  Govarts, Eva and  Bruckers, Liesbeth and  Morrens, Bert and  Loots, Ilse and  De Decker, Annelies and  Nelen, Vera and  Nawrot, Tim and De Henauw, Stefaan and  Van Larebeke, Nik and  Schoeters, Greet and  Covaci, Adrian}},
  issn         = {{0160-4120}},
  journal      = {{ENVIRONMENT INTERNATIONAL}},
  keywords     = {{Organophosphate flame retardants,Exposure assessment,Human,biomonitoring,FLEHS IV,Belgium,Adolescents}},
  language     = {{eng}},
  pages        = {{10}},
  publisher    = {{Pergamon-Elsevier Science LTD}},
  title        = {{Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14-15 years) from the Flemish environment and health}},
  url          = {{http://doi.org/10.1016/j.envint.2020.106368}},
  volume       = {{147}},
  year         = {{2021}},
}
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