@phdthesis{01GVQM1RN9TKDDF100GM469M08,
  abstract     = {{As an intercellular, interspecies, and interkingdom signaling molecule, indole plays important roles in bacterial pathogenesis. Indole can be produced by various bacteria and is widespread in the natural environment. It has been shown to control diverse aspects of bacterial physiology, such as biofilm formation, motility, drug resistance, and virulence. Recently, several indole analogues were also reported to have a similar activity as indole and affect the virulence of different bacteria. However, the impacts of indole and indole analogues towards vibrios that are pathogenic in aquaculture, were mostly unknown.
In this PhD research, we evaluated the impact of indole on the virulence of 14 strains of vibrios belonging to the Harveyi clade and the Splendidus clade, which are important aquaculture pathogens that infect aquatic animals and cause various diseases leading to huge economic losses. Furthermore, in order to identify more potent therapeutic agents and to determine structure-activity relationships of indole analogues with respect to virulence inhibition, we explored the effect of 70 indole analogues on the virulence of V. campbellii BB120 in the gnotobiotic brine shrimp (Artemia franciscana) model. All of the work presented in this thesis indicates that indole affects the virulence in both Harveyi clade and Splendidus clade vibrios, and indole analogues showed a highly protective effect on brine shrimp larvae against V. campbellii. All of the data demonstrate that indole analogues have the potential to be novel disease control agents for aquaculture.}},
  author       = {{Zhang, Shanshan}},
  isbn         = {{9789463575942}},
  keywords     = {{indole,analogues,vibrio,antivirulence}},
  language     = {{eng}},
  pages        = {{IV, 212}},
  publisher    = {{Ghent University. Faculty of Bioscience Engineering}},
  school       = {{Ghent University}},
  title        = {{Antivirulence potential of indole and indole analogues against vibrios}},
  year         = {{2023}},
}