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Personalized statistical modeling of soft tissue structures in the knee

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Abstract
Background and Objective: As in vivo measurements of knee joint contact forces remain challenging, computational musculoskeletal modeling has been popularized as an encouraging solution for non-invasive estimation of joint mechanical loading. Computational musculoskeletal modeling typically relies on laborious manual segmentation as it requires reliable osseous and soft tissue geometry. To improve on feasibility and accuracy of patient-specific geometry predictions, a generic computational approach that can easily be scaled, morphed and fitted to patient-specific knee joint anatomy is presented.Methods: A personalized prediction algorithm was established to derive soft tissue geometry of the knee, originating solely from skeletal anatomy. Based on a MRI dataset (n = 53), manual identification of soft-tissue anatomy and landmarks served as input for our model by use of geometric morphometrics. Topographic distance maps were generated for cartilage thickness predictions. Meniscal modeling relied on wrapping a triangular geometry with varying height and width from the anterior to the posterior root. Elastic mesh wrapping was applied for ligamentous and patellar tendon path modeling. Leave-one-out validation experiments were conducted for accuracy assessment.Results: The Root Mean Square Error (RMSE) for the cartilage layers of the medial tibial plateau, the lateral tibial plateau, the femur and the patella equaled respectively 0.32 mm (range 0.14-0.48), 0.35 mm (range 0.16-0.53), 0.39 mm (range 0.15-0.80) and 0.75 mm (range 0.16-1.11). Similarly, the RMSE equaled respectively 1.16 mm (range 0.99-1.59), 0.91 mm (0.75-1.33), 2.93 mm (range 1.85-4.66) and 2.04 mm (1.88-3.29), calculated over the course of the anterior cruciate ligament, posterior cruciate ligament, the medial and the lateral meniscus.Conclusion: A methodological workflow is presented for patient-specific, morphological knee joint modeling that avoids laborious segmentation. By allowing to accurately predict personalized geometry this method has the potential for generating large (virtual) sample sizes applicable for biomechanical research and improving personalized, computer-assisted medicine.
Keywords
Biomedical Engineering, Histology, Bioengineering, Biotechnology, knee joint, personalized medicine, statistical shape modeling, soft-tissue modeling, computational modeling

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MLA
Van Oevelen, Aline, et al. “Personalized Statistical Modeling of Soft Tissue Structures in the Knee.” FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 11, Frontiers Media SA, 2023, doi:10.3389/fbioe.2023.1055860.
APA
Van Oevelen, A., Duquesne, K., Peiffer, M., Grammens, J., Burssens, A., Chevalier, A., … Audenaert, E. (2023). Personalized statistical modeling of soft tissue structures in the knee. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 11. https://doi.org/10.3389/fbioe.2023.1055860
Chicago author-date
Van Oevelen, Aline, Kate Duquesne, Matthias Peiffer, Jonas Grammens, Arthur Burssens, Amélie Chevalier, G. Steenackers, Jan Victor, and Emmanuel Audenaert. 2023. “Personalized Statistical Modeling of Soft Tissue Structures in the Knee.” FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 11. https://doi.org/10.3389/fbioe.2023.1055860.
Chicago author-date (all authors)
Van Oevelen, Aline, Kate Duquesne, Matthias Peiffer, Jonas Grammens, Arthur Burssens, Amélie Chevalier, G. Steenackers, Jan Victor, and Emmanuel Audenaert. 2023. “Personalized Statistical Modeling of Soft Tissue Structures in the Knee.” FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 11. doi:10.3389/fbioe.2023.1055860.
Vancouver
1.
Van Oevelen A, Duquesne K, Peiffer M, Grammens J, Burssens A, Chevalier A, et al. Personalized statistical modeling of soft tissue structures in the knee. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2023;11.
IEEE
[1]
A. Van Oevelen et al., “Personalized statistical modeling of soft tissue structures in the knee,” FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 11, 2023.
@article{01GVJ8W1K90C6AVX3W4K7AEFEF,
  abstract     = {{Background and Objective: As in vivo measurements of knee joint contact forces remain challenging, computational musculoskeletal modeling has been popularized as an encouraging solution for non-invasive estimation of joint mechanical loading. Computational musculoskeletal modeling typically relies on laborious manual segmentation as it requires reliable osseous and soft tissue geometry. To improve on feasibility and accuracy of patient-specific geometry predictions, a generic computational approach that can easily be scaled, morphed and fitted to patient-specific knee joint anatomy is presented.Methods: A personalized prediction algorithm was established to derive soft tissue geometry of the knee, originating solely from skeletal anatomy. Based on a MRI dataset (n = 53), manual identification of soft-tissue anatomy and landmarks served as input for our model by use of geometric morphometrics. Topographic distance maps were generated for cartilage thickness predictions. Meniscal modeling relied on wrapping a triangular geometry with varying height and width from the anterior to the posterior root. Elastic mesh wrapping was applied for ligamentous and patellar tendon path modeling. Leave-one-out validation experiments were conducted for accuracy assessment.Results: The Root Mean Square Error (RMSE) for the cartilage layers of the medial tibial plateau, the lateral tibial plateau, the femur and the patella equaled respectively 0.32 mm (range 0.14-0.48), 0.35 mm (range 0.16-0.53), 0.39 mm (range 0.15-0.80) and 0.75 mm (range 0.16-1.11). Similarly, the RMSE equaled respectively 1.16 mm (range 0.99-1.59), 0.91 mm (0.75-1.33), 2.93 mm (range 1.85-4.66) and 2.04 mm (1.88-3.29), calculated over the course of the anterior cruciate ligament, posterior cruciate ligament, the medial and the lateral meniscus.Conclusion: A methodological workflow is presented for patient-specific, morphological knee joint modeling that avoids laborious segmentation. By allowing to accurately predict personalized geometry this method has the potential for generating large (virtual) sample sizes applicable for biomechanical research and improving personalized, computer-assisted medicine.}},
  articleno    = {{1055860}},
  author       = {{Van Oevelen, Aline and Duquesne, Kate and Peiffer, Matthias and Grammens, Jonas and Burssens, Arthur and Chevalier, Amélie and Steenackers, G. and Victor, Jan and Audenaert, Emmanuel}},
  issn         = {{2296-4185}},
  journal      = {{FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY}},
  keywords     = {{Biomedical Engineering,Histology,Bioengineering,Biotechnology,knee joint,personalized medicine,statistical shape modeling,soft-tissue modeling,computational modeling}},
  language     = {{eng}},
  pages        = {{19}},
  publisher    = {{Frontiers Media SA}},
  title        = {{Personalized statistical modeling of soft tissue structures in the knee}},
  url          = {{http://doi.org/10.3389/fbioe.2023.1055860}},
  volume       = {{11}},
  year         = {{2023}},
}

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