- Author
- Marre Porré, Gianmarco Pisanò, Fady Nahra (UGent) and Catherine Cazin (UGent)
- Organization
- Abstract
- alpha-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that alpha-bromo-, alpha-chloro-, and alpha-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability.
- Keywords
- SOLVENT-FREE CONDITIONS, ONE-POT SYNTHESIS, AEROBIC OXIDATIVE, IODINATION, HIGHLY EFFICIENT SYNTHESIS, CO-CATALYZED HYDRATION, ARYL, METHYL KETONES, CARBONYL-COMPOUNDS, N-BROMOSUCCINIMIDE, IONIC LIQUID, HYDROGEN-PEROXIDE, haloketones, building block, organic synthesis
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01GVE178AA4A34SAZYVTFFXAMM
- MLA
- Porré, Marre, et al. “Synthetic Access to Aromatic Alpha-Haloketones.” MOLECULES, vol. 27, no. 11, 2022, doi:10.3390/molecules27113583.
- APA
- Porré, M., Pisanò, G., Nahra, F., & Cazin, C. (2022). Synthetic access to aromatic alpha-haloketones. MOLECULES, 27(11). https://doi.org/10.3390/molecules27113583
- Chicago author-date
- Porré, Marre, Gianmarco Pisanò, Fady Nahra, and Catherine Cazin. 2022. “Synthetic Access to Aromatic Alpha-Haloketones.” MOLECULES 27 (11). https://doi.org/10.3390/molecules27113583.
- Chicago author-date (all authors)
- Porré, Marre, Gianmarco Pisanò, Fady Nahra, and Catherine Cazin. 2022. “Synthetic Access to Aromatic Alpha-Haloketones.” MOLECULES 27 (11). doi:10.3390/molecules27113583.
- Vancouver
- 1.Porré M, Pisanò G, Nahra F, Cazin C. Synthetic access to aromatic alpha-haloketones. MOLECULES. 2022;27(11).
- IEEE
- [1]M. Porré, G. Pisanò, F. Nahra, and C. Cazin, “Synthetic access to aromatic alpha-haloketones,” MOLECULES, vol. 27, no. 11, 2022.
@article{01GVE178AA4A34SAZYVTFFXAMM,
abstract = {{alpha-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that alpha-bromo-, alpha-chloro-, and alpha-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability.}},
articleno = {{3583}},
author = {{Porré, Marre and Pisanò, Gianmarco and Nahra, Fady and Cazin, Catherine}},
issn = {{1420-3049}},
journal = {{MOLECULES}},
keywords = {{SOLVENT-FREE CONDITIONS,ONE-POT SYNTHESIS,AEROBIC OXIDATIVE,IODINATION,HIGHLY EFFICIENT SYNTHESIS,CO-CATALYZED HYDRATION,ARYL,METHYL KETONES,CARBONYL-COMPOUNDS,N-BROMOSUCCINIMIDE,IONIC LIQUID,HYDROGEN-PEROXIDE,haloketones,building block,organic synthesis}},
language = {{eng}},
number = {{11}},
pages = {{53}},
title = {{Synthetic access to aromatic alpha-haloketones}},
url = {{http://doi.org/10.3390/molecules27113583}},
volume = {{27}},
year = {{2022}},
}
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